Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry

Autor: Shizhong Ke, Fabin Dang, Lin Wang, Jia-Yun Chen, Mandar T. Naik, Wenxue Li, Abhishek Thavamani, Nami Kim, Nandita M. Naik, Huaxiu Sui, Wei Tang, Chenxi Qiu, Kazuhiro Koikawa, Felipe Batalini, Emily Stern Gatof, Daniela Arango Isaza, Jaymin M. Patel, Xiaodong Wang, John G. Clohessy, Yujing J. Heng, Galit Lahav, Yansheng Liu, Nathanael S. Gray, Xiao Zhen Zhou, Wenyi Wei, Gerburg M. Wulf, Kun Ping Lu

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-act

Externí odkaz: https://doaj.org/article/0b6bab263e5b452fb61f77b6a5e52d6a

Massive Thymic Hyperplasia Masquerading as Cancer: A Case Report and Review of the Literature

Autor: Emily Stern Gatof, MD, Sarmad H. Jassim, MD, Leah Ahn, MD, Zsu-Zsu Chen, MD, Paul A. VanderLaan, MD, PhD, Deepa Rangachari, MD

Publikováno v: JTO Clinical and Research Reports, Vol 4, Iss 2, Pp 100463- (2023)

A 34-year-old woman presenting with abdominal pain, chest pressure, weight loss, and tachycardia was found to have an 11.4-cm anterior mediastinal mass associated with intrathoracic lymphadenopathy on chest computed tomography (Fig. 1A). Core needle

Externí odkaz: https://doaj.org/article/9b65cca330534e6eb57544bd277e85f7

Abstract P5-12-03: Intratumor heterogeneity and intrinsic immune activation are associated with response to chemotherapy in BRCA-related breast cancers

Autor: Felipe Batalini, Doga C. Gulhan, Xanthi Lida Katopodi, Nikolas Kalavros, Antuan Tran, Dimitra Karagkouni, Emily Stern-Gatof, Stuart Schnitt, Judy E. Garber, Gerburg M. Wulf, Peter J. Park, Ioannis Vlachos, Nadine Tung

Publikováno v: Cancer Research. 83:P5-12

Background Breast cancers in women with a germline BRCA1/2 mutation (gBRCAm) have homologous recombination deficiency (HRD) and are sensitive to therapies causing double-strand DNA breaks. In TBCRC 031 (INFORM), both neoadjuvant cisplatin and doxorub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::225c6bbf0d4d72b8011aead8cfde79c6
https://doi.org/10.1158/1538-7445.sabcs22-p5-12-03

Financial Conflicts of Interest Change After a High-Impact Clinical Trial Publication in Oncology

Autor: Glen J. Weiss, Craig L. Cambridge, Roger B. Davis, Emily Stern Gatof

Publikováno v: Journal of Patient-Centered Research and Reviews, Vol 7, Iss 3, Pp 249-254 (2020)
J Patient Cent Res Rev

Purpose: Because financial conflicts of interest (FCOIs) may potentially influence patient care, hospital drug formularies, and treatment guidelines, it is important that these are disclosed. The purpose of this observational study was to quantify th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77546439078bce5d5968c396ba68e963
https://doi.org/10.17294/2330-0698.1735

An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility

Autor: Yukio Nakamura, Sukhpal Prehar, Esther Baena, Ryo Kurita, Adnan Ali, Guillaume Lettre, Daniel E. Bauer, Samuel Lessard, Patrick G Schupp, Emily Stern Gatof, Falak Sher, Mélissa Beaudoin, Jonathan Ledoux, Delvac Oceandy

Publikováno v: Lessard, S, Stern Gatof, E, Beaudoin, M, Schupp, P G, Sher, F, Prehar, S, Ali, S A, Kurita, R, Nakamura, Y, Baena Chaparro, E, Ledoux, J, Oceandy, D, Bauer, D & Lettre, G 2017, ' An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility ', Journal of Clinical Investigation, vol. 127, no. 8, pp. 3065-3074 . https://doi.org/10.1172/JCI94378

The lack of mechanistic explanations for many genotype-phenotype associations identified by GWAS precludes thorough assessment of their impact on human health. Here, we conducted an expression quantitative trait locus (eQTL) mapping analysis in eryth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3876020fc66f7d51f14eaf87c533c6bc
https://doi.org/10.1172/JCI94378