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pro vyhledávání: '"Emily Spierings"'
Autor:
Zahra Sabouri, Samuel Perotti, Emily Spierings, Peter Humburg, Mehmet Yabas, Hannes Bergmann, Keisuke Horikawa, Carla Roots, Samantha Lambe, Clara Young, T. Dan Andrews, Matthew Field, Anselm Enders, Joanne H. Reed, Christopher C. Goodnow
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Self-reactive B cells that are anergic express mainly IgD, yet the function of IgD is not clear. Here the authors analyse primary B cells from mice to show that IgD signalling attenuates self-antigen induced gene expression and promotes survival of a
Externí odkaz:
https://doaj.org/article/33bf5d14b2104b7e9e5694830f9f9ee0
Autor:
Mehmet Yabas, Keisuke Horikawa, Clara Young, Samuel Perotti, Christopher C. Goodnow, Zahra Sabouri, Samantha Lambe, Hannes Bergmann, Carla M. Roots, Emily Spierings, Peter Humburg, Joanne H. Reed, T. Dan Andrews, Matthew A. Field, Anselm Enders
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Self-tolerance by clonal anergy of B cells is marked by an increase in IgD and decrease in IgM antigen receptor surface expression, yet the function of IgD on anergic cells is obscure. Here we define the RNA landscape of the in vivo anergy response,