Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Emily Sechrest"'
Autor:
Celine Brooks, Douglas Kolson, Emily Sechrest, Janelle Chuah, Jane Schupp, Neil Billington, Wen-Tao Deng, David Smith, Maxim Sokolov
Publikováno v:
PLoS ONE, Vol 19, Iss 10, p e0308058 (2024)
Neurodegenerative diseases are characterized by the presence of misfolded and aggregated proteins which are thought to contribute to the development of the disease. In one form of inherited blinding disease, retinitis pigmentosa, a P23H mutation in t
Externí odkaz:
https://doaj.org/article/bbae70956c7444609e93ae590e85223d
Autor:
Sree Motipally, Boyden Myers, Emily Sechrest, David Sokolov, Joseph Murphy, Saravanan Kolandaivelu
Publikováno v:
Bio-Protocol, Vol 13, Iss 8 (2023)
Palmitoylation is a unique and reversible posttranslational lipid modification (PTM) that plays a critical role in many cellular events, including protein stability, activity, membrane association, and protein–protein interactions. The dynamic natu
Externí odkaz:
https://doaj.org/article/91513f366bd54eba85d2b4bbfd07576d
Autor:
Brunilde Gril, Patricia S. Steeg, Priscilla K. Brastianos, Naema Nayyar, Renata Duchnowska, Ewa Izycka-Swieszewska, Wojciech Kloc, Seth M. Steinberg, David J. Liewehr, Diane Palmieri, Emily Hua, Emily Sechrest, Afroz Shareef Mohammad, Chris E. Adkins, Paul R. Lockman, L. Tiffany Lyle
Purpose: The blood–brain barrier (BBB) is modified to a blood–tumor barrier (BTB) as a brain metastasis develops from breast or other cancers. We (i) quantified the permeability of experimental brain metastases, (ii) determined the composition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9f6a23dc74202c049512d6d2c895e8
https://doi.org/10.1158/1078-0432.c.6523620
https://doi.org/10.1158/1078-0432.c.6523620
Autor:
Brunilde Gril, Patricia S. Steeg, Priscilla K. Brastianos, Naema Nayyar, Renata Duchnowska, Ewa Izycka-Swieszewska, Wojciech Kloc, Seth M. Steinberg, David J. Liewehr, Diane Palmieri, Emily Hua, Emily Sechrest, Afroz Shareef Mohammad, Chris E. Adkins, Paul R. Lockman, L. Tiffany Lyle
Supplemental Tables. Supplemental Tables S1-6. Table S1. Antibodies used for quantification and concentrations. Table S2. Antibodies that could not be quantified in the model systems under fixation conditions used to identify Texas Red dextran permea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ae0f24212cd903564fb0a185ea74d0
https://doi.org/10.1158/1078-0432.22457559.v1
https://doi.org/10.1158/1078-0432.22457559.v1
Autor:
Subhadip Senapati, Joseph Murphy, Emily Sechrest, Andrew F.X. Goldberg, Paul S.-H. Park, Saravanan Kolandaivelu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Progressive rod-cone degeneration (PRCD) is a small protein localized to photoreceptor outer segment (OS) disc membranes. Several mutations in PRCD are linked to retinitis pigmentosa (RP) in canines and humans, and while recent studies have establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae47d556840a241a02d951e0717a2e80
http://link.springer.com/article/10.1038/s41598-020-74628-2
http://link.springer.com/article/10.1038/s41598-020-74628-2
Despite mounting evidence that the mammalian retina is exceptionally reliant on proper NAD+ homeostasis for health and function, the specific roles of subcellular NAD+ pools in retinal development, maintenance, and disease remain obscure. Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8536f3bb3aea4b6b4737b1e18eed55
https://doi.org/10.1101/2021.05.05.442836
https://doi.org/10.1101/2021.05.05.442836
Autor:
Neal Shah, Emily Sechrest, Jessica Griffith, Chris E. Adkins, Paul R. Lockman, Afroz S. Mohammad, Emma L. Dolan, Tori B. Terrell-Hall
Publikováno v:
Clinical & Experimental Metastasis. 33:373-383
The blood brain barrier (BBB) is compromised in brain metastases, allowing for enhanced drug permeation into brain. The extent and heterogeneity of BBB permeability in metastatic lesions is important when considering the administration of chemotherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c893a4376efa71aada4d4d30baae6f36
https://doi.org/10.1007/s10585-016-9784-z
https://doi.org/10.1007/s10585-016-9784-z
Autor:
Neal Shah, Afroz S. Mohammad, Helen Lee, Emma L. Dolan, Tori B. Terrell-Hall, Jessica Griffith, Chris E. Adkins, Emily Sechrest, Bart S. Hendriks, Paul R. Lockman
The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central nervous system. However, given that the BTB has increased passive permeability we hypothesize that liposomal irinotecan would improve local exposure of irinotecan a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae950b9bee030174be1013955ccc4781
https://europepmc.org/articles/PMC5884086/
https://europepmc.org/articles/PMC5884086/
Autor:
Afroz S. Mohammad, Priscilla K. Brastianos, David J. Liewehr, Diane Palmieri, Ewa Izycka-Swieszewska, Naema Nayyar, Seth M. Steinberg, L. Tiffany Lyle, Patricia S. Steeg, Paul R. Lockman, Renata Duchnowska, Emily Hua, Wojciech Kloc, Brunilde Gril, Emily Sechrest, Chris E. Adkins
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(21)
Purpose: The blood–brain barrier (BBB) is modified to a blood–tumor barrier (BTB) as a brain metastasis develops from breast or other cancers. We (i) quantified the permeability of experimental brain metastases, (ii) determined the composition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89273b476ce5cb54b2a4e25ef678ce86
https://pubmed.ncbi.nlm.nih.gov/27245829
https://pubmed.ncbi.nlm.nih.gov/27245829
Autor:
Emily Hua, Patricia S. Steeg, L. Tiffany Lyle, David J. Liewehr, Emily Sechrest, Paul R. Lockman, Nayyar Naema, Diane Palmieri, Afroz S. Mohammad, Brunilde Gril, Ewa Izycka-Swieszewska, Chris E. Adkins, Seth M. Steinberg, Renata Duchnowska, Priscilla K. Brastianos, Wojciech Kloc
Publikováno v:
Cancer Research. 77:4933-4933
Breast cancer brain metastases remain incurable. The blood-brain barrier (BBB) is a multicellular dynamic structure regulating exchanges between the blood and the central nervous system. As cancer cells colonize the brain, the BBB evolves into a bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9699382f4dd684a31331c0f2b00cfb3e
https://doi.org/10.1158/1538-7445.am2017-4933
https://doi.org/10.1158/1538-7445.am2017-4933