Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Emily S. Wong"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Enhancers are fast-evolving genomic sequences that control spatiotemporal gene expression patterns. By examining enhancer turnover across mammalian species and in multiple tissue types, we uncover a relationship between the emergence of enha
Externí odkaz:
https://doaj.org/article/f4ef7b6f6aee4e1093c1bcbb53c9429e
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their flexible organization and functional redundancies make deciphering their sequence-function relationships challenging. This article provides an overview of t
Externí odkaz:
https://doaj.org/article/ddd1c9a21b37444689a0321ba8329525
Autor:
Mahdi Moradi Marjaneh, Edwin P Kirk, Ralph Patrick, Dimuthu Alankarage, David T Humphreys, Gonzalo Del Monte-Nieto, Paola Cornejo-Paramo, Vaibhao Janbandhu, Tram B Doan, Sally L Dunwoodie, Emily S Wong, Chris Moran, Ian CA Martin, Peter C Thomson, Richard P Harvey
Publikováno v:
eLife, Vol 12 (2023)
Unlike single-gene mutations leading to Mendelian conditions, common human diseases are likely to be emergent phenomena arising from multilayer, multiscale, and highly interconnected interactions. Atrial and ventricular septal defects are the most co
Externí odkaz:
https://doaj.org/article/b0e177240240418384f4ea4e88aaa1c8
Publikováno v:
Hong Kong Medical Journal. 29:22-30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8237db52ccdf4b3f8c57cc6466ffa3f
https://doi.org/10.12809/hkmj209241
https://doi.org/10.12809/hkmj209241
Autor:
Emily S. Wong, Bianca M. Schmitt, Anastasiya Kazachenka, David Thybert, Aisling Redmond, Frances Connor, Tim F. Rayner, Christine Feig, Anne C. Ferguson-Smith, John C. Marioni, Duncan T. Odom, Paul Flicek
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
“Variation in the noncoding regulatory sequences in the genome plays important roles in human disease and evolution. Here, the authors use F1 mouse hybrids to shed light on the regulatory mechanisms mediating transcription factor binding, chromatin
Externí odkaz:
https://doaj.org/article/94b3385fc76e4d38a4ca428bdd92d65a
Autor:
Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang, Paola Cornejo, Forrest C. Koch, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S. Woll, Diego Chacon Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O’ Brien, Annette Trickett, Jason A. Powell, Ian D. Lewis, Stuart M. Pitson, Maher K. Gandhi, Steven W. Lane, Fatemeh Vafaee, Emily S. Wong, Berthold Göttgens, Hamid Alinejad Rokny, Jason W.H Wong, John E. Pimanda
SummaryHematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2 - bind regulatory eleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41942e05e1ce4a56162d13a406b33d8c
https://doi.org/10.1101/2023.04.18.537282
https://doi.org/10.1101/2023.04.18.537282
Autor:
Katie A. Fennell, Dane Vassiliadis, Enid Y. N. Lam, Luciano G. Martelotto, Jesse J. Balic, Sebastian Hollizeck, Tom S. Weber, Timothy Semple, Qing Wang, Denise C. Miles, Laura MacPherson, Yih-Chih Chan, Andrew A. Guirguis, Lev M. Kats, Emily S. Wong, Sarah-Jane Dawson, Shalin H. Naik, Mark A. Dawson
Publikováno v:
Nature. 601:125-131
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eca5ec36241dd90dcfbc07c2d0e36859
https://doi.org/10.1038/s41586-021-04206-7
https://doi.org/10.1038/s41586-021-04206-7
Unlike protein-coding regions, enhancers generally evolve rapidly. By examining enhancer turnover across mammalian species and in multiple tissue-types, we uncovered a relationship between the emergence of novel enhancers and genome organization, ref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d369f7f56779e3b143aa5ab66e9481da
https://doi.org/10.1101/2022.12.22.521323
https://doi.org/10.1101/2022.12.22.521323
Autor:
Wei Zhang, Chi Pui Pang, Alvin L. Young, Emily S. Wong, Posey Po-Yin Wong, Clement C Y Tham, Li Jia Chen, Ka Wai Kam, Benjamin Hon Kei Yip, Patrick Ip, Yuzhou Zhang, Jason C. S. Yam, Xiu Juan Zhang
Publikováno v:
Ophthalmic Epidemiology. 29:621-628
To determine the prevalence of amblyopia and the factors associated with delayed diagnosis among school-aged children in Hong Kong.Completed comprehensive ophthalmoscopic examinations were conducted among 4.273 children aged 6-8 years in the populati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bb280bbf314cd106f1b7121ba7ed14
https://doi.org/10.1080/09286586.2021.1986551
https://doi.org/10.1080/09286586.2021.1986551
Autor:
Mahdi Moradi Marjaneh, Edwin P. Kirk, Ralph Patrick, Dimuthu Alankerage, David T. Humphreys, Gonzalo Del Monte-Nieto, Paola Cornejo-Paramo, Vaibhao Janbandhu, Tram B. Doan, Sally L. Dunwoodie, Emily S. Wong, Chris Moran, Ian C.A. Martin, Peter C. Thomson, Richard P. Harvey
Unlike single-gene mutations leading to Mendelian conditions, common human diseases are likely emergent phenomena arising from multilayer, multiscale and highly interconnected interactions. Atrial and ventricular septal defects are the most common fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb1d5ef3551c3b6e0b1bf051361d06f
https://doi.org/10.1101/2022.10.31.514499
https://doi.org/10.1101/2022.10.31.514499