Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Emily S. Shen"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:5986-5995
An unusual combination of Weinreb amidation and Mitsunobu lactam formation was used to prepare highly substituted gamma-lactam analogues of a thiazolidinone follicle stimulating hormone receptor agonist. The analogue synthesis was stereoselective and
Autor:
Jill L. Hardenburg, John Rogers, Darlene C. Deecher, Francisco J. López, Emily S. Shen, Brian J. Arey, Jay Wrobel, James W Jetter, M. Claudia Perez, Daniel M. Green, Wenling Kao
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:639-656
Screening efforts identified (bis)sulfonic acid, (bis)benzamides (1-3) as compounds that interact with the follicle stimulating-hormone receptor (FSHR) and inhibit FSH-stimulated cAMP accumulation with IC(50) values in the low micromolar range. Struc
Autor:
Francisco J. López, Donald E. Frail, Panayiotis E. Stevis, Darlene C. Deecher, Andres Negro-Vilar, Emily S. Shen, Brian J. Arey
Publikováno v:
Molecular Endocrinology. 11:517-526
Under physiological conditions, FSH is secreted into the circulation as a complex mixture of several isoforms that vary in the degree of glycosylation. Although it is well established that the glycosylation of FSH is important for the serum half-life
Autor:
Leah A. Breth, Alan K. Robbins, Emily S. Shen, Karen Sperle, Brian L. Largent, Christian C. Reid, Gary M. Cooke, Robert A. Horlick
Publikováno v:
Protein Expression and Purification. 9:301-308
Human HEK293 cells that stably express the Epstein Barr nuclear antigen 1 (EBNA1) support the episomal replication of plasmids containing the Epstein Barr virus origin of replication (EBV oriP). A 293EBNA (293E) cell line expressing the human cortico
Publikováno v:
Gene. 156:235-239
Levels of expression of two reporter genes cloned into SV40 or Epstein-Barr virus (EBV) ori -containing plasmids were measured following transient transfection of cell lines constitutively expressing T-antigen or EBV nuclear antigen 1 (EBNA1). The TS
Publikováno v:
Journal of Biological Chemistry. 268:6575-6580
The DNA upstream of the dioxin-inducible CYP1A1 gene contains six distinct sites to which the liganded Ah receptor binds in intact mouse hepatoma cells. Here, we have analyzed these six bona fide receptor-binding sites in order to study the relations
Autor:
Emily S. Shen, James P. Whitlock
Publikováno v:
Journal of Biological Chemistry. 267:6815-6819
The liganded Ah receptor activates transcription by binding to a specific DNA-recognition motif within a dioxin-responsive enhancer upstream of the CYP1A1 gene. Analyses of mutant enhancers by gel retardation reveal that each base pair within the dom
Publikováno v:
Journal of Toxicology and Environmental Health. 32:367-381
The toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined by clinical chemistry and liver histopathology in Ah-responsive C57BL/6J (C57) and Ah-nonresponsive DBA/2J (DBA) mice. Hepatotoxicity was assessed at 1, 3, and 7 d following a si
Autor:
Joshua E. Cottom, Edwin H. Meade, Gregory S. Kopf, William H. Hoffman, Murty V. Chengalvala, Linda Shanno, May M. Wu, Emily S. Shen
Publikováno v:
Current Pharmaceutical Design. 12
Mammalian reproduction is a complex physiological process involving a tightly regulated hypothalamic-pituitary-gonadal axis and the integration of a diverse array of molecular signals. Oral contraceptives (OCs) were introduced over 40 years ago and h
Autor:
Erik A. Whitehorn, Ronald W. Barrett, Barbara Aguilar, Christopher P. Holmes, Richard C. Winneker, May M. Wu, Derek Maclean, Randall A. Scheuerman, Emily S. Shen, Donald E. Frail, Emily Tate, Francisco J. López, Frank Holden, Stephen D. Yanofsky, Brian J. Arey
Publikováno v:
The Journal of biological chemistry. 281(19)
The pituitary glycoprotein hormones, luteinizing hormone and follicle-stimulating hormone (FSH), act through their cognate receptors to initiate a series of coordinated physiological events that results in germ cell maturation. Given the importance o