Výsledky vyhledávání - "Emily S. Meymand"

Akademický článek

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression

Autor: Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett, Michael X. Henderson

Publikováno v: Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-20 (2024)

Abstract Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate the LRRK2 kinase activity, making LRRK2 kinase inhibitors an attractive therapeutic. LRRK2

Externí odkaz: https://doaj.org/article/1f84f0e37fc14d51a4c531d8dca9e20e

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Akademický článek

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

Autor: Norihito Uemura, Nicholas P. Marotta, Jahan Ara, Emily S. Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C. Luk, John Q. Trojanowski, Virginia M.-Y. Lee

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We recently demonstrated

Externí odkaz: https://doaj.org/article/c249b84834e1414cabb7db6ae3c525cf

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Akademický článek

Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro

Autor: Nicholas P. Marotta, Jahan Ara, Norihito Uemura, Marshall G. Lougee, Emily S. Meymand, Bin Zhang, E. James Petersson, John Q. Trojanowski, Virginia M.-Y. Lee

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)

Abstract Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological features of many neurodegenerative diseases. They consist largely of aggregated forms of the protein alpha-Synuclein (α-Syn), which misfolds to give rise t

Externí odkaz: https://doaj.org/article/bf7a534148ef4b5692dfe56fe3d96872

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Akademický článek

Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

Autor: Garrett S. Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M. Riddle, Susan N. Leight, Lakshmi Changolkar, Hong Xu, Emily S. Meymand, Mia O’Reilly, Bin Zhang, Kurt R. Brunden, John Q. Trojanowski, Virginia M. Y. Lee

Publikováno v: Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)

Abstract Background The spread of tau pathology in Alzheimer’s disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon internalization by recipient neurons, template the misfolding of naïve

Externí odkaz: https://doaj.org/article/09dd55fddba54de1b0145828289b3cae

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Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro

Autor: John Q. Trojanowski, Nicholas P. Marotta, Marshall G. Lougee, E. James Petersson, Emily S. Meymand, Jahan Ara, Virginia M.-Y. Lee, Bin Zhang, Norihito Uemura

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)

Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological features of many neurodegenerative diseases. They consist largely of aggregated forms of the protein alpha-Synuclein (α-Syn), which misfolds to give rise to beta-sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e0eb97f64e3a5cbecde94e01b56930
https://pubmed.ncbi.nlm.nih.gov/34819159

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Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice

Autor: Virginia M.-Y. Lee, Modupe F. Olufemi, An De Bondt, John Q. Trojanowski, Ilse Van den Wyngaert, Bin Zhang, Annelies Nonneman, Argyro Thalia Delizannis, Shaniya Maimaiti, Kurt R. Brunden, Wangchen Tsering, Pyry Koivula, Emily S. Meymand

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Acta Neuropathologica Communications

Dystrophic neuronal processes harboring neuritic plaque (NP) tau pathology are found in association with Aβ plaques in Alzheimer’s disease (AD) brain. Microglia are also in proximity to these plaques and microglial gene variants are known risk fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7a66c7aed48b83c3d5f9f2818c9500
https://doi.org/10.1186/s40478-021-01251-1

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Distinct brain-derived TDP-43 strains from FTLD-TDP subtypes induce diverse morphological TDP-43 aggregates and spreading patterns in vitro and in vivo

Autor: Yan Xu, Anna Stieber, Emily S. Meymand, Tagan Lehr, Bin Zhang, Edward B. Lee, John Q. Trojanowski, Sílvia Porta, Virginia M.-Y. Lee, Modupe F. Olufemi

Publikováno v: Neuropathol Appl Neurobiol

Aim The heterogeneity in the distribution and morphological features of TAR DNA-binding protein-43 (TDP-43) pathology in the brains of frontotemporal lobar degeneration (FTLD-TDP) patients and their different clinical manifestations suggest that dist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9992f4697115febcfac8be40df81e4
https://europepmc.org/articles/PMC8578586/

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Author response for 'Distinct brain-derived TDP-43 strains from FTLD-TDP subtypes induce diverse morphological TDP-43 aggregates and spreading patterns in vitro and in vivo'

Autor: Virginia M. Y. Lee, Anna Stieber, Modupe F. Olufemi, Bin Zhang, John Q. Trojanowski, Tagan Lehr, Sílvia Porta, Emily S. Meymand, Yan Xu, Edward B. Lee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08542d49acc69a863da2a9ac9371e928
https://doi.org/10.1111/nan.12732/v2/response1

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Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

Autor: Hong Xu, Bin Zhang, Garrett S. Gibbons, Dawn M. Riddle, Mia O’Reilly, Kurt R. Brunden, Emily S. Meymand, Qihui Wu, Virginia M.-Y. Lee, John Q. Trojanowski, Lakshmi Changolkar, Susan Leight, Soo-Jung Kim

Publikováno v: Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)

BackgroundThe spread of tau pathology in Alzheimer’s disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon internalization by recipient neurons, template the misfolding of naïve cellular t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38187d84c538a237376b12ae386e15c
http://europepmc.org/articles/PMC7643305

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α-Synuclein modulates tau spreading in mouse brains

Autor: Bin Zhang, Virginia M.-Y. Lee, Chantal M. Maghames, Timothy O. Cox, Qihui Wu, Shankar Pattabhiraman, Hong Xu, Fares Bassil, John Q. Trojanowski, Hannah J. Brown, Emily S. Meymand

Publikováno v: The Journal of Experimental Medicine

Bassil et al. model the crosstalk of α-syn and tau under copathology conditions. They show evidence of α-syn–dependent tau pathology in the human brain. Moreover, they demonstrate the role of α-syn in the modulation of tau pathology in mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd3151a66c4f178a53710a3388003d8
https://doi.org/10.1084/jem.20192193

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