Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Emily S Wires"'
Autor:
Emily S Wires, Mark J Henderson, Xiaokang Yan, Susanne Bäck, Kathleen A Trychta, Molly H Lutrey, Brandon K Harvey
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175481 (2017)
The endoplasmic reticulum (ER) is essential to many cellular processes including protein processing, lipid metabolism and calcium storage. The ability to longitudinally monitor ER homeostasis in the same organism would offer insight into progressive
Externí odkaz:
https://doaj.org/article/28b46d22dc31411cab9dc1b2884dec9d
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-11 (2022)
Abstract Background Aberrations to endoplasmic/sarcoplasmic reticulum (ER/SR) calcium concentration can result in the departure of endogenous proteins in a phenomenon termed exodosis. Redistribution of the ER/SR proteome can have deleterious effects
Externí odkaz:
https://doaj.org/article/fd93747235684bd5a467c03348f87f42
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-35 (2020)
Abstract Background Pathogenic variations in the gene encoding the skeletal muscle ryanodine receptor (RyR1) are associated with malignant hyperthermia (MH) susceptibility, a life-threatening hypermetabolic condition and RYR1-related myopathies (RYR1
Externí odkaz:
https://doaj.org/article/7a62b41e32a4459eb65dc74103516518
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5436, p 5436 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The KDEL receptor retrieval pathway is essential for maintaining resident proteins in the endoplasmic reticulum (ER) lumen. ER resident proteins serve a variety of functions, including protein folding and maturation. Perturbations to the lumenal ER m
Autor:
Fumihiko Urano, Alexey V. Zakharov, Xiaokang Yan, Adam Yasgar, David G. Maloney, Kuo Jen Wu, Susanne Bäck, Xin Hu, Dingyin Tao, Xin Xu, Ganesha Rai, Hideaki Yano, Oksana Gavrilova, Carina Danchik, Brandon K. Harvey, Ajit Jadhav, Mikko Airavaara, Shyh Ming Yang, Anton Simeonov, Amy Wang, Mark J. Henderson, Kathleen A. Trychta, Yun Wang, Gergely Zahoránszky-Kőhalmi, Lei Shi, Emily S. Wires
Publikováno v:
Cell Rep
Endoplasmic reticulum (ER) dysregulation is associated with pathologies including neurodegenerative, muscular, and diabetic conditions. Depletion of ER calcium can lead to the loss of resident proteins in a process termed exodosis. To identify compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533304cff990505d799ec3e79ecffb6b
https://europepmc.org/articles/PMC8545458/
https://europepmc.org/articles/PMC8545458/
Publikováno v:
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-35 (2020)
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-35 (2020)
BackgroundPathogenic variations in the gene encoding the skeletal muscle ryanodine receptor (RyR1) are associated with malignant hyperthermia (MH) susceptibility, a life-threatening hypermetabolic condition andRYR1-related myopathies (RYR1-RM), a spe
Autor:
Mark J. Henderson, Emily S. Wires, Christopher T. Richie, Kathleen A. Trychta, Brandon K. Harvey
Publikováno v:
Molecular Biology of the Cell
Depletion of ER calcium can lead to cell death and is implicated in numerous diseases. Secreted ER calcium-monitoring proteins (SERCaMPs) are secreted in response to ER calcium depletion. SERCaMPs identified ER calcium depletion in primary neurons ex
Autor:
Kenner C. Rice, Emily S. Wires, Kathleen A. Trychta, Brandon K. Harvey, Susanne Bäck, Agnieszka Sulima
Publikováno v:
Journal of hepatology. 67(5)
Background & Aims Disruption to endoplasmic reticulum (ER) calcium homeostasis has been implicated in obesity, however, the ability to longitudinally monitor ER calcium fluctuations has been challenging with prior methodologies. We recently described
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 79
Stroke is the leading cause of disability in adults. Drug treatments that target stroke-induced pathological mechanisms and promote recovery are desperately needed. In the brain, an ischemic event triggers major inflammatory responses that are mediat
Autor:
Katrina Albert, Lisa C. Loram, Kert Mätlik, Brandon K. Harvey, Emily S. Wires, Yun Wang, Jenni E. Anttila, Mikko Airavaara, Linda R. Watkins, Kenner C. Rice
Publikováno v:
eNeuro
Ischemic stroke is the leading cause of disability, and effective therapeutic strategies are needed to promote complete recovery. Neuroinflammation plays a significant role in stroke pathophysiology, and there is limited understanding of how it affec