Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Emily Rome"'
Autor:
Joseph J. Campo, Emily Romeis, Amit Oberai, Jozelyn V. Pablo, Christopher Hung, Andy A. Teng, Adam D. Shandling, Amber Phan, Austin M. Haynes, Lorenzo Giacani
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110618- (2024)
Summary: Given the resurgence of syphilis, research endeavors to improve current assays for serological diagnosis and management of this disease are a priority. A proteome-scale platform for high-throughput profiling of the humoral response to Trepon
Externí odkaz:
https://doaj.org/article/a32660fe02d948409d1d2783e262ae2e
Publikováno v:
Cahiers Élisabéthains: A Journal of English Renaissance Studies. 100:98-101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04732aa76b5f3781e522c071d95a560
https://doi.org/10.1177/0184767819867410i
https://doi.org/10.1177/0184767819867410i
Autor:
Austin M. Haynes, Kelika A. Konda, Emily Romeis, Janet Siebert, Silver K. Vargas, Michael Reyes Diaz, Amber Phan, Carlos F. Caceres, Lorenzo Giacani, Jeffrey D. Klausner
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Syphilis is a multistage chronic sexually transmitted infection caused by the spirochete Treponema pallidum subsp. pallidum (T. pallidum). Today, syphilis is still endemic in low- and middle-income nations and has become resurgent in many hi
Externí odkaz:
https://doaj.org/article/3531bc9746234403b18e01808ff79eb2
Autor:
Emily Romeis, Nicole A P Lieberman, Barbara Molini, Lauren C Tantalo, Benjamin Chung, Quynh Phung, Carlos Avendaño, Anastassia Vorobieva, Alexander L Greninger, Lorenzo Giacani
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011259 (2023)
BackgroundThe TprK protein of the syphilis agent, Treponema pallidum subsp. pallidum (T. pallidum), undergoes antigenic variation in seven discrete variable (V) regions via non-reciprocal segmental gene conversion. These recombination events transfer
Externí odkaz:
https://doaj.org/article/3637a32b0e5d45cab49823cc0c655e9f
Autor:
Nicole A. P. Lieberman, Thaddeus D. Armstrong, Benjamin Chung, Daniel Pfalmer, Christopher M. Hennelly, Austin Haynes, Emily Romeis, Qian-Qiu Wang, Rui-Li Zhang, Cai-Xia Kou, Giulia Ciccarese, Ivano Dal Conte, Marco Cusini, Francesco Drago, Shu-ichi Nakayama, Kenichi Lee, Makoto Ohnishi, Kelika A. Konda, Silver K. Vargas, Maria Eguiluz, Carlos F. Caceres, Jeffrey D. Klausner, Oriol Mitja, Anne Rompalo, Fiona Mulcahy, Edward W. Hook, Irving F. Hoffman, Mitch M. Matoga, Heping Zheng, Bin Yang, Eduardo Lopez-Medina, Lady G. Ramirez, Justin D. Radolf, Kelly L. Hawley, Juan C. Salazar, Sheila A. Lukehart, Arlene C. Seña, Jonathan B. Parr, Lorenzo Giacani, Alexander L. Greninger
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Sequencing of most Treponema pallidum genomes excludes repeat regions in tp0470 and the tp0433 gene, encoding the acidic repeat protein (arp). As a first step to understanding the evolution and function of these genes and the proteins they encode, we
Externí odkaz:
https://doaj.org/article/f8331bd84d0e47898e3a5a42a1a23551
Autor:
Nicole A P Lieberman, Michelle J Lin, Hong Xie, Lasata Shrestha, Tien Nguyen, Meei-Li Huang, Austin M Haynes, Emily Romeis, Qian-Qiu Wang, Rui-Li Zhang, Cai-Xia Kou, Giulia Ciccarese, Ivano Dal Conte, Marco Cusini, Francesco Drago, Shu-Ichi Nakayama, Kenichi Lee, Makoto Ohnishi, Kelika A Konda, Silver K Vargas, Maria Eguiluz, Carlos F Caceres, Jeffrey D Klausner, Oriol Mitjà, Anne Rompalo, Fiona Mulcahy, Edward W Hook, Sheila A Lukehart, Amanda M Casto, Pavitra Roychoudhury, Frank DiMaio, Lorenzo Giacani, Alexander L Greninger
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010063 (2021)
In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgen
Externí odkaz:
https://doaj.org/article/f8f88374a8944331bc4a55f2256ab665
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009612 (2021)
Despite more than a century of research, genetic manipulation of Treponema pallidum subsp. pallidum (T. pallidum), the causative agent of syphilis, has not been successful. The lack of genetic engineering tools has severely limited understanding of t
Externí odkaz:
https://doaj.org/article/2416de458b6342998c140c10f7ea5636
Autor:
Austin M. Haynes, Lorenzo Giacani, Marti Vall Mayans, Maria Ubals, Carles Nieto, Clara Pérez-Mañá, Llorenç Quintó, Emily Romeis, Oriol Mitjà
Publikováno v:
EBioMedicine, Vol 65, Iss , Pp 103281- (2021)
Background: Penicillin G, the current standard treatment for syphilis, has important drawbacks, but virtually no preclinical or clinical studies have been performed to identify viable alternatives. We tested, both in vitro and in vivo, three marketed
Externí odkaz:
https://doaj.org/article/02aa0be3c9f043cdb2a3c8e40303594c
Autor:
Austin M Haynes, Mark Fernandez, Emily Romeis, Oriol Mitjà, Kelika A Konda, Silver K Vargas, Maria Eguiluz, Carlos F Caceres, Jeffrey D Klausner, Lorenzo Giacani
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008812 (2021)
BackgroundAn effective syphilis vaccine should elicit antibodies to Treponema pallidum subsp. pallidum (T. p. pallidum) surface antigens to induce pathogen clearance through opsonophagocytosis. Although the combination of bioinformatics, structural,
Externí odkaz:
https://doaj.org/article/79c1ce648f5047c2b1978ae77c39ff73