Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Emily R. Theisen"'
Autor:
Rachel D. Dreher, Emily R. Theisen
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Sarcomas are a diverse group of tumors with numerous oncogenic drivers, and display varied clinical behaviors and prognoses. This complexity makes diagnosis and the development of new and effective treatments challenging. An incomplete understanding
Externí odkaz:
https://doaj.org/article/6c313ca8299c437fbc3831b53a422477
Autor:
Emily R. Theisen, Julia Selich-Anderson, Kyle R. Miller, Jason M. Tanner, Cenny Taslim, Kathleen I. Pishas, Sunil Sharma, Stephen L. Lessnick
Publikováno v:
Epigenetics, Vol 16, Iss 4, Pp 405-424 (2021)
Paediatric cancers commonly harbour quiet mutational landscapes and are instead characterized by single driver events such as the mutation of critical chromatin regulators, expression of oncohistones, or expression of oncogenic fusion proteins. These
Externí odkaz:
https://doaj.org/article/26487376c9f44df0b15af5824dea094e
Autor:
Iftekhar A Showpnil, Julia Selich-Anderson, Cenny Taslim, Megann A Boone, Jesse C Crow, Emily R Theisen, Stephen L Lessnick
Publikováno v:
Nucleic Acids Research. 50:9814-9837
Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or a highly related FET/ETS chimera. EWS/FLI dysregulates transcription to induce and maintain sarcomagenesis, but the mechanisms utilized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada230c4af9f84f8be7476f7086a69ac
https://doi.org/10.1093/nar/gkac747
https://doi.org/10.1093/nar/gkac747
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
GSK-LSD1, Doxorubicin and AraC have no effect on KDM1A and KDM1B expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1051ce09797e7b498c067f204794a86
https://doi.org/10.1158/1535-7163.22509571.v1
https://doi.org/10.1158/1535-7163.22509571.v1
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
Protein expression of ER-stress response genes following treatment with SP-2509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0388e4ca3b246780959d79b84a856ff2
https://doi.org/10.1158/1535-7163.22509565.v1
https://doi.org/10.1158/1535-7163.22509565.v1
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
Targeted KDM1A inhibition and EWS/FLI knockdown induces similar transcriptional signatures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43708ed7fd5e4213822a969dd241bbbf
https://doi.org/10.1158/1535-7163.22509577
https://doi.org/10.1158/1535-7163.22509577
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
Hypersensitive SP-2509 cell lines display similar transcriptomic profiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e17f939c8c1e534cd2c8eaf60fb9562
https://doi.org/10.1158/1535-7163.22509568.v1
https://doi.org/10.1158/1535-7163.22509568.v1
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
Cell line source/culture conditions, primer/shRNA sequences, antibodies utilized in this study and additional methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a730c92e76e8d6e5c012ae04934f7d3
https://doi.org/10.1158/1535-7163.22509559
https://doi.org/10.1158/1535-7163.22509559
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
Validation of KDM1A knockdown in Ewing sarcoma cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46aec94be9920dac3b2aee9af9cda637
https://doi.org/10.1158/1535-7163.22509580
https://doi.org/10.1158/1535-7163.22509580
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
Multi-agent chemotherapeutic regimes remain the cornerstone treatment for Ewing sarcoma, the second most common bone malignancy diagnosed in pediatric and young adolescent populations. We have reached a therapeutic ceiling with conventional cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dadafa9852d23357beb019700fb0a2
https://doi.org/10.1158/1535-7163.c.6539329
https://doi.org/10.1158/1535-7163.c.6539329