Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis

Autor: Kevin Lee, Wimeth Dissanayake, Melissa MacLiesh, Cih-Li Hong, Zi Yin, Yuko Kawano, Christina M. Kaszuba, Hiroki Kawano, Emily R. Quarato, Brian Marples, Michael Becker, Jeevisha Bajaj, Laura M. Calvi, Shu-Chi A. Yeh

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Recent advances in imaging suggested that spatial organization of hematopoietic cells in their bone marrow microenvironment (niche) regulates cell expansion, governing progression, and leukemic transformation of hematological clonal disorder

Externí odkaz: https://doaj.org/article/39066cfbf9da4bac8aa29d11c5369e48

Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1

Autor: Moore, Negar Khazan, Emily R. Quarato, Niloy A. Singh, Cameron W. A. Snyder, Taylor Moore, John P. Miller, Masato Yasui, Yuki Teramoto, Takuro Goto, Sabeeha Reshi, Jennifer Hong, Naixin Zhang, Diya Pandey, Priyanka Srivastava, Alexandra Morell, Hiroki Kawano, Yuko Kawano, Thomas Conley, Deepak M. Sahasrabudhe, Naohiro Yano, Hiroshi Miyamoto, Omar Aljitawi, Jane Liesveld, Michael W. Becker, Laura M. Calvi, Alexander S. Zhovmer, Erdem D. Tabdanov, Nikolay V. Dokholyan, David C. Linehan, Jeanne N. Hansen, Scott A. Gerber, Ashoke Sharon, Manoj K. Khera, Peter W. Jurutka, Natacha Rochel, Kyu Kwang Kim, Rachael B. Rowswell-Turner, Rakesh K. Singh, Richard G.

Publikováno v: Cancers; Volume 15; Issue 13; Pages: 3432

Small-molecule inhibitors of PD-L1 are postulated to control immune evasion in tumors similar to antibodies that target the PD-L1/PD-1 immune checkpoint axis. However, the identity of targetable PD-L1 inducers is required to develop small-molecule PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::5acfce91bbbcc2034d880aecbd34605b

Isocitrate Dehydrogenase 2 Mutation Drives Bone Marrow Macrophage Dysfunction without a Complete Block in Hematopoietic Differentiation

Autor: Noah Salama, Olivia Lynch, Emily R Quarato, Yuko Kawano, Benjamin Rodems, Eric Cefaloni, Tzu-Chieh Ho, Kathleen E. McGrath, Michael W. Becker, Jane L. Liesveld, Paula M Vertino, James Palis, Jeevisha Bajaj, Laura M. Calvi

Publikováno v: Blood. 140:9757-9758

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::661d97e24a591dde2f123251b46b731c
https://doi.org/10.1182/blood-2022-168015

Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1.

Autor: Khazan, Negar¹ (AUTHOR) alexandra_morell@urmc.rochester.edu, Quarato, Emily R.² (AUTHOR), Singh, Niloy A.¹ (AUTHOR) kyukwang_kim@urmc.rochester.edu, Snyder, Cameron W. A.¹ (AUTHOR) richard_moore@urmc.rochester.edu, Moore, Taylor¹ (AUTHOR), Miller, John P.^1,3 (AUTHOR), Yasui, Masato⁴ (AUTHOR) yabomabo@gmail.com, Teramoto, Yuki⁴ (AUTHOR), Goto, Takuro⁴ (AUTHOR), Reshi, Sabeeha⁵ (AUTHOR), Hong, Jennifer⁵ (AUTHOR), Zhang, Naixin¹ (AUTHOR), Pandey, Diya¹ (AUTHOR), Srivastava, Priyanka¹ (AUTHOR), Morell, Alexandra¹ (AUTHOR), Kawano, Hiroki⁶ (AUTHOR) thomas_conely@urmc.rochester.edu, Kawano, Yuko⁶ (AUTHOR), Conley, Thomas⁶ (AUTHOR), Sahasrabudhe, Deepak M.⁶ (AUTHOR), Yano, Naohiro⁷ (AUTHOR) naohiro_yano@brown.edu

Publikováno v: Cancers. Jul2023, Vol. 15 Issue 13, p3432. 17p.

Study Findings from University of Rochester Medical Center Provide New Insights into Acute Myeloid Leukemia (Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1).

Publikováno v: Hematology Week; 8/1/2023, p2200-2200, 1p