Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Emily R. Finch"'
Autor:
Qian Dong, Cheng Chen, Nan Song, Na Qin, Noel-Marie Plonski, Emily R. Finch, Kyla Shelton, John Easton, Heather Mulder, Emily Plyer, Geoffrey Neale, Emily Walker, Qian Li, I-Chan Huang, Jinghui Zhang, Hui Wang, Melissa M. Hudson, Leslie L. Robison, Kirsten K. Ness, Zhaoming Wang
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background DNA methylation (DNAm) plays an important role in lipid metabolism, however, no epigenome-wide association study (EWAS) of lipid levels has been conducted among childhood cancer survivors. Here, we performed EWAS analysis with lon
Externí odkaz:
https://doaj.org/article/b732bfd52f4840fc9346c01ff04bd7c9
Autor:
Fenghua Qian, Shaneice K. Nettleford, Jiayan Zhou, Brooke E. Arner, Molly A. Hall, Arati Sharma, Charyguly Annageldiyev, Randy M. Rossi, Diwakar B. Tukaramrao, Deborpita Sarkar, Shailaja Hegde, Ujjawal H. Gandhi, Emily R. Finch, Laura Goodfield, Michael D. Quickel, David F. Claxton, Robert F. Paulson, K. Sandeep Prabhu
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112794- (2023)
Summary: Relapse of acute myeloid leukemia (AML) remains a significant concern due to persistent leukemia-initiating stem cells (LICs) that are typically not targeted by most existing therapies. Using a murine AML model, human AML cell lines, and pat
Externí odkaz:
https://doaj.org/article/ce35a814bf814b97aa20a01a202f9e01
Publikováno v:
Aging and Cancer, Vol 2, Iss 4, Pp 112-128 (2021)
Abstract Background Estimates indicate that nearly 8% of the over 500,000 survivors of childhood cancer living in the United States are frail in their fourth and fifth decades of life, a phenotype typically seen in geriatric populations. Participatio
Externí odkaz:
https://doaj.org/article/4c576a9786d346b39f681bae6d43645a
Autor:
Matthew D. Wogksch, Emily R. Finch, Vikki G. Nolan, Matthew P. Smeltzer, Fawaz Mzayek, Chelsea G. Goodenough, Ching-Hon Pui, Hiroto Inaba, Daniel A. Mulrooney, Sue C. Kaste, Tara M. Brinkman, Jennifer Q. Lanctot, Deo Kumar Srivastava, John L. Jefferies, Gregory T. Armstrong, Leslie L. Robison, Melissa M. Hudson, Kirsten K. Ness
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
PurposeAdult survivors of childhood acute lymphoblastic leukemia (ALL) have impaired adaptive physical function and poor health-related quality of life (HRQoL). Obesity may contribute to these impairments by increasing the physiological cost of walki
Externí odkaz:
https://doaj.org/article/89f0bccc03a8411bbff7caa59694ee6e
Autor:
Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
Chemotherapy dosages are often compromised, but most reports lack data on dosages that are actually delivered. In two consecutive acute lymphoblastic leukemia trials that differed in their asparaginase formulation, native E. coli L-asparaginase in St
Externí odkaz:
https://doaj.org/article/f2f424e701944bfb90237067ca32533f
Autor:
Emily R. Finch, Monique A. Payton, David A. Jenkins, Xiangjun Cai, Lie Li, Seth E. Karol, Mary V. Relling, Laura J. Janke
Publikováno v:
Haematologica, Vol 106, Iss 8 (2020)
Recent clinical trials in children with acute lymphoblastic leukemia (ALL) indicate that severe hypertriglyceridemia (> 1000 mg/dL) during therapy is associated with increased frequency of symptomatic osteonecrosis. Interventions to lower triglycerid
Externí odkaz:
https://doaj.org/article/b72a3812607843a9a7d34e5b30060c08
Autor:
Noel-Marie Plonski, Cheng Chen, Qian Dong, Na Qin, Nan Song, Hemang M. Parikh, Kyla Shelton, Emily R. Finch, John Easton, Heather Mulder, Jinghui Zhang, Geoffrey Neale, Emily Walker, Hui Wang, Kevin Krull, Kirsten K. Ness, Melissa M. Hudson, Leslie L. Robison, Qian Li, AnnaLynn Williams, Zhaoming Wang
36 Importance: We previously demonstrated that some cancer therapies are strong risk factors for 37 epigenetic age acceleration (EAA) among childhood cancer survivors, and EAA is associated with chronic 38 health conditions (CHCs). However, these dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6784f7195f37dfe8db36085a13bc17
Autor:
K. Sandeep Prabhu, Robert F. Paulson, Jay Whelan, Mary J. Kennett, Laura L. Goodfield, Michael D. Quickel, Avinash K. Kudva, Emily R. Finch
Current therapies for treatment of myeloid leukemia do not eliminate leukemia stem cells (LSC), leading to disease relapse. In this study, we supplemented mice with eicosapentaenoic acid (EPA, C20:5), a polyunsaturated omega-3 fatty acid, at pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d782de0ae58dca19d72c7b489efe09
https://doi.org/10.1158/1940-6207.c.6544929
https://doi.org/10.1158/1940-6207.c.6544929
Autor:
K. Sandeep Prabhu, Robert F. Paulson, Jay Whelan, Mary J. Kennett, Laura L. Goodfield, Michael D. Quickel, Avinash K. Kudva, Emily R. Finch
Supplemental Figure 1: Blood parameters in healthy mice are not affected by diet. Supplemental Figure 2: EPA decreases CML in EPA supplemented mice. Supplemental Figure 3: The antileukemic effect of EPA supplementation is dependent on functional prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436c1f198a46f0446d79ac359f643b3a
https://doi.org/10.1158/1940-6207.22525833.v1
https://doi.org/10.1158/1940-6207.22525833.v1
Autor:
K. Sandeep Prabhu, Robert F. Paulson, Craig T. Jordan, Mary J. Kennett, Avinash K. Kudva, Emily R. Finch, Shailaja Hegde, Naveen Kaushal, Ujjawal H. Gandhi
PDF file - 772KB, Supplementary Figure 1. Selenium supplementation abrogates leukemia in a Friend leukemia (FVP) model. Supplementary Figure 2. Effect of selenium supplementation on the splenic histopathology in FVP-infected mice. Supplementary Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309987a607a3b378168c79648b61279e
https://doi.org/10.1158/0008-5472.22404105
https://doi.org/10.1158/0008-5472.22404105