Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Emily R Webb"'
Autor:
Emily R Webb, Georgia L Dodd, Michaela Noskova, Esme Bullock, Morwenna Muir, Margaret C Frame, Alan Serrels, Valerie G Brunton
Publikováno v:
eLife, Vol 12 (2023)
The adhesion protein Kindlin-1 is over-expressed in breast cancer where it is associated with metastasis-free survival; however, the mechanisms involved are poorly understood. Here, we report that Kindlin-1 promotes anti-tumor immune evasion in mouse
Externí odkaz:
https://doaj.org/article/c3ca53b8a4394469ab79acf4dee4d370
Autor:
Emily R. Webb, Julia Moreno-Vincente, Alistair Easton, Silvia Lanati, Martin Taylor, Sonya James, Emily L. Williams, Vikki English, Chris Penfold, Stephen A. Beers, Juliet C. Gray
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104995- (2022)
Summary: The outcome for children with high-risk neuroblastoma is poor despite intensive multi-modal treatment protocols. Toxicity from current treatments is significant, and novel approaches are needed to improve outcome. Cyclophosphamide (CPM) is a
Externí odkaz:
https://doaj.org/article/202fa5d00d4141d88bafe43b46b1e0e7
Autor:
Emily R. Webb, Silvia Lanati, Carol Wareham, Alistair Easton, Stuart N. Dunn, Tatyana Inzhelevskaya, Freja M. Sadler, Sonya James, Margaret Ashton-Key, Mark S. Cragg, Stephen A. Beers, Juliet C. Gray
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Immunotherapy offers a potentially less toxic, more tumor-specific treatment for neuroblastoma than conventional cytotoxic therapies. Accurate and reproducible immune competent preclinical models are key to understanding mechanisms of action
Externí odkaz:
https://doaj.org/article/1cd179c8bd0e4a0ba1a1db6fa9ea0186
Autor:
Asier Unciti-Broceta, Neil O. Carragher, Valerie G. Brunton, Bin-Zhi Qian, Margaret C. Frame, Mark J. Arends, Maria Lopalco, Christina Schoenherr, Henry Beetham, Craig Fraser, Juan R. Luque-Ortega, Rafael Contreras-Montoya, Alison F. Munro, Teresa Valero, Kenneth G. Macleod, Morwenna Muir, John C. Dawson, Xue-Feng Li, Emily R. Webb, Daniel Lietha, Carolin Temps
Supplementary Data from A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f536ea2ccfc4256e470e9896ed6057b
https://doi.org/10.1158/0008-5472.22428648.v1
https://doi.org/10.1158/0008-5472.22428648.v1
Autor:
Asier Unciti-Broceta, Neil O. Carragher, Valerie G. Brunton, Bin-Zhi Qian, Margaret C. Frame, Mark J. Arends, Maria Lopalco, Christina Schoenherr, Henry Beetham, Craig Fraser, Juan R. Luque-Ortega, Rafael Contreras-Montoya, Alison F. Munro, Teresa Valero, Kenneth G. Macleod, Morwenna Muir, John C. Dawson, Xue-Feng Li, Emily R. Webb, Daniel Lietha, Carolin Temps
Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance mechanisms of many solid malignancies, inhibition of its kinase activity has thus far failed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92e862f8d441136de23e083b6c89a273
https://doi.org/10.1158/0008-5472.c.6513090.v1
https://doi.org/10.1158/0008-5472.c.6513090.v1
Autor:
Emily R Webb, Georgia Dodd, Esme Bullock, Morwenna Muir, Margaret C Frame, Alan Serrels, Valerie G Brunton
The adhesion protein Kindlin-1 is over-expressed in breast cancer where it has been shown to be associated with metastasis-free survival, however, the mechanisms involved are poorly understood. Here, we report that Kindlin-1 promotes anti-tumor immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c6a3a8668a25307c140dfcc918dfdbf
https://doi.org/10.1101/2022.03.04.483014
https://doi.org/10.1101/2022.03.04.483014
Autor:
Carolin Temps, Christina Schoenherr, John C. Dawson, Rafael Contreras-Montoya, Craig Fraser, Emily R. Webb, Valerie G. Brunton, Juan Román Luque-Ortega, Alison F. Munro, Xue-Feng Li, Bin-Zhi Qian, Morwenna Muir, Neil O. Carragher, Teresa Valero, Daniel Lietha, Kenneth G. MacLeod, Asier Unciti-Broceta, Maria Lopalco, Margaret C. Frame, Mark J. Arends, Henry Beetham
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Temps, C, Leitha, D, Webb, E, Li, X-F, Dawson, J C, Muir, M, Macleod, K, Valero, T, Munro, A, Contreras-montoya, R, Luque-Ortega, J R, Fraser, C, Beetham, H, Schoenherr, C, Lopalco, M, Arends, M J, Frame, M C, Qian, B-Z, Brunton, V G, Carragher, N O & Unciti-Broceta, A 2021, ' A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0613
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Temps, C, Leitha, D, Webb, E, Li, X-F, Dawson, J C, Muir, M, Macleod, K, Valero, T, Munro, A, Contreras-montoya, R, Luque-Ortega, J R, Fraser, C, Beetham, H, Schoenherr, C, Lopalco, M, Arends, M J, Frame, M C, Qian, B-Z, Brunton, V G, Carragher, N O & Unciti-Broceta, A 2021, ' A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0613
Digibug. Repositorio Institucional de la Universidad de Granada
C. Temps thanks the CMVM of the University of Edinburgh (Principal's scholarship). D. Lietha acknowledges support from the Spanish Ministry of Science, Innovation, and Universities for the Spanish State Research Agency Retos Grant RTI2018-099318-B-I0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ebf74a44141d28c0c386286b9df44f
http://hdl.handle.net/10261/251621
http://hdl.handle.net/10261/251621
Autor:
Emily R Webb, Sonya James, Tatyana Inzhelevskaya, Alistair Easton, Freja M Sadler, Silvia Lanati, Margaret Ashton-Key, Stephen A. Beers, Carol Wareham, Stuart N. Dunn, Juliet C. Gray, Mark S. Cragg
Publikováno v:
Webb, E R, Lanati, S, Wareham, C, Easton, A, Dunn, S N, Inzhelevskaya, T, Sadler, F M, James, S, Ashton-Key, M, Cragg, M S, Beers, S A & Gray, J C 2020, ' Immune characterization of pre-clinical murine models of neuroblastoma ', Scientific Reports, vol. 10, no. 1, 16695 . https://doi.org/10.1038/s41598-020-73695-9
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Immunotherapy offers a potentially less toxic, more tumor-specific treatment for neuroblastoma than conventional cytotoxic therapies. Accurate and reproducible immune competent preclinical models are key to understanding mechanisms of action, interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7040d338b2c88b82612dd7aba7ac602
https://hdl.handle.net/20.500.11820/f2df8389-6fef-4341-8e68-db28f884b7f7
https://hdl.handle.net/20.500.11820/f2df8389-6fef-4341-8e68-db28f884b7f7