Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Emily R Summerbell"'
Autor:
Tala O Khatib, Angelica M Amanso, Christina M Knippler, Brian Pedro, Emily R Summerbell, Najdat M Zohbi, Jessica M Konen, Janna K Mouw, Adam I Marcus
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292554 (2023)
Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing, in situ hybridization, and flow cytometry. While these approaches have revolutionized
Externí odkaz:
https://doaj.org/article/fe27ed5d193243e1a74544f879fb7a81
Autor:
Nergis Kara, Matthew R. Kent, Dominic Didiano, Kamya Rajaram, Anna Zhao, Emily R. Summerbell, James G. Patton
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2037-2047.e4 (2019)
Summary: Unlike the adult mammalian retina, Müller glia (MG) in the adult zebrafish retina are able to dedifferentiate into a “stem cell”-like state and give rise to multipotent progenitor cells upon retinal damage. We show that miR-216a is down
Externí odkaz:
https://doaj.org/article/150b6a3f9f7645ff92dc3ef6f863dec3
Autor:
Tala O. Khatib, Angelica M. Amanso, Brian Pedro, Christina M. Knippler, Emily R. Summerbell, Najdat M. Zohbi, Jessica M. Konen, Janna K. Mouw, Adam I. Marcus
Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing,in situhybridization, and flow cytometry. While these approaches have revolutionized ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeb7f9eee2c52274b913d127287314cf
https://doi.org/10.1101/2023.02.28.530493
https://doi.org/10.1101/2023.02.28.530493
Autor:
Benjamin G. Barwick, Jamie L. Arnst, Joshua S.K. Bell, Jeanne Kowalski, Brian Pedro, Sandra Seby, Jessica Konen, Bhakti Dwivedi, Adam I. Marcus, Rachel Commander, Paula M. Vertino, Tala O. Khatib, Christina M. Knippler, Janna K. Mouw, Emily R. Summerbell
Publikováno v:
Science Advances
Specialized leader cells use stable filopodia to create linear fibronectin tracks to promote collective cancer invasion.
Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored
Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991ed2b8d54a42351bc931f2c60d9d8e
https://doi.org/10.1126/sciadv.aaz6197
https://doi.org/10.1126/sciadv.aaz6197
Autor:
Wei Zhou, Darius Mahboubi, L. J. Burton, Aditi Sharma, Jessica Konen, R. J. Peterson, Mala Shanmugam, Janna K. Mouw, Adam I. Marcus, Rachel Commander, Yuhong Du, Changyong Wei, Haian Fu, Emily R. Summerbell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Phenotypic heterogeneity exists within collectively invading packs of tumor cells, suggesting that cellular subtypes cooperate to drive invasion and metastasis. Here, we take a chemical biology approach to probe cell:cell cooperation within the colle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf48a0697e878a1fbdf81b80301df65e
https://doi.org/10.1038/s41467-020-15219-7
https://doi.org/10.1038/s41467-020-15219-7
Publikováno v:
Cancer Research. 79:178-178
Myosin-X (MYO10) is a noncanonical myosin that drives filopodia formation and extension, and is necessary for invasion and metastasis of breast cancer, prostate cancer and melanoma. It is not yet known by what mechanism MYO10 increases cancer cell in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d1de401691485d9ceda26ce5f3cf387
https://doi.org/10.1158/1538-7445.am2019-178
https://doi.org/10.1158/1538-7445.am2019-178
Autor:
Manali Rupji, Brian Pedro, Paula M. Vertino, Janna K. Mouw, Jeanne Kowalski, Emily R. Summerbell, Jessica Konen, Bhakti Dwivedi, Adam I. Marcus
Publikováno v:
Cancer Research. 79:4590-4590
Previous work has demonstrated heterogeneity within collectively invading packs of lung cancer cells, including leader and follower cells that cooperate to facilitate invasion into the microenvironment. In order to better characterize the genetic dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b51ec2f888d236b4ce94d83fd23137df
https://doi.org/10.1158/1538-7445.am2019-4590
https://doi.org/10.1158/1538-7445.am2019-4590
Autor:
Elizabeth L. Zoeller, Adam I. Marcus, Joshua S.K. Bell, Jessica Konen, Jeanne Kowalski, Paula M. Vertino, Emily R. Summerbell
Publikováno v:
Cancer Research. 77:1962-1962
Histone modifying enzymes are often dysregulated during carcinogenesis and are major contributors to the development of oncogenic features, including proliferation, drug resistance, and metastasis. Given these roles, histone modifiers are promising n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8eadc38614cb9aa5121f5eb0904717a
https://doi.org/10.1158/1538-7445.am2017-1962
https://doi.org/10.1158/1538-7445.am2017-1962
Publikováno v:
Molecular Vision
Zebrafish are capable of robust and spontaneous regeneration of injured retina. Constant intense light exposure to adult albino zebrafish specifically causes apoptosis of rod and cone photoreceptor cells and is an excellent model to study the molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91bea22b81e69ce91523fb7f030ece64
https://pubmed.ncbi.nlm.nih.gov/25324680
https://pubmed.ncbi.nlm.nih.gov/25324680
Autor:
Jeanne Kowalski, Khalid Salaita, Jessica Konen, Bhakti Dwivedi, Adam I. Marcus, Emily R. Summerbell, Kornelia Galior
Publikováno v:
Cancer Research. 76:LB-355
During tumor metastasis, cancer cells invade as a phenotypically heterogeneous collective pack to navigate the tumor microenvironment. Leader cells pioneer invasion into the microenvironment whereas follower cells immediately attach to and follow the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e45b091d0e9b96c4e20ed86df6dcd77b
https://doi.org/10.1158/1538-7445.am2016-lb-355
https://doi.org/10.1158/1538-7445.am2016-lb-355