Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Emily Pisha"'
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 550:109-121
Long-term exposure to synthetic and endogenous estrogens has been associated with the development of cancer in several tissues. One potential mechanism of estrogen carcinogenesis involves catechol formation and these catechols are further oxidized to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d8653eccb4599dee75968bb2c33f3d
https://doi.org/10.1016/j.mrfmmm.2004.02.005
https://doi.org/10.1016/j.mrfmmm.2004.02.005
Autor:
Emily Pisha, Debra A. Tonetti, Xuemei Liu, Dan Yao, Joanna E. Burdette, Yan Li, Judy L. Bolton, Jiaqin Yao
Publikováno v:
Chemical Research in Toxicology. 16:832-837
The antiestrogen, tamoxifen, has been extensively used in the treatment and prevention of breast cancer. Although tamoxifen showed benefits in the chemotherapy and chemoprevention of breast cancer, epidemiological studies in both tamoxifen-treated br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9056ea4bb5caf631a4ebf70dc936b25
https://doi.org/10.1021/tx030004s
https://doi.org/10.1021/tx030004s
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1707-1712
Betulinic acid has been modified at C-3, C-20, and C-28 positions and the toxicity of the derivatives has been evaluated against cultured human melanoma (MEL-2) and human epidermoid carcinoma of the mouth (KB) cell lines. This preliminary investigati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5d649db711ac34964e3b335b9d5f88
https://doi.org/10.1016/s0960-894x(98)00295-9
https://doi.org/10.1016/s0960-894x(98)00295-9
Autor:
Li Shen, Emily Pisha, Richard B. van Breemen, John M. Pezzuto, Suzanne L. Iverson, Zhiwen Huang, Judy L. Bolton, E. S. Krol
Publikováno v:
Chemico-Biological Interactions. 106:133-148
Catechols are widespread in the environment, especially as constituents of edible plants. A number of these catechols may undergo oxidative metabolism to electrophilic o-quinones (3,5-cyclohexadien-1,2-dione) by oxidative enzymes such as cytochrome P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5285740e6311b940c8a72fee81f7e0ee
https://doi.org/10.1016/s0009-2797(97)00066-5
https://doi.org/10.1016/s0009-2797(97)00066-5
Autor:
Emily Pisha, John M. Pezzuto
Publikováno v:
Methods in Cell Science. 19:37-43
Methods are described for assessing the estrogenic or anti-estrogenic potential of test substances using cultured (human endometrial) Ishikawa cells. This cell line possesses an estrogen-inducible alkaline phosphatase, and estrogenic activity is indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50e402927124218131085782a2cdca98
https://doi.org/10.1023/a:1009746605060
https://doi.org/10.1023/a:1009746605060
Autor:
Emily Pisha, Heebyung Chai, Ik-Soo Lee, Tangai E. Chagwedera, Norman R. Farnsworth, Geoffrey A. Cordell, Christopher W.W. Beecher, Harry H.S. Fong, A. Douglas Kinghorn, Daniel M. Brown, Mansukh C. Wani, Monroe E. Wall, Tina J. Hieken, Tapas K. Das Gupta, John M. Pezzuto
Publikováno v:
Nature Medicine. 1:1046-1051
As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma-specific cytotoxic agent. In follow-up studies conducted with athymic mice carrying human melanomas, tumour growth was completely inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab77191eb2ecbca8aaed1be6d82b467
https://doi.org/10.1038/nm1095-1046
https://doi.org/10.1038/nm1095-1046
Publikováno v:
ChemInform. 29
Betulinic acid has been modified at C-3, C-20, and C-28 positions and the toxicity of the derivatives has been evaluated against cultured human melanoma (MEL-2) and human epidermoid carcinoma of the mouth (KB) cell lines. This preliminary investigati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fdde518a55ef3b9353f3416a7b7d11d
https://doi.org/10.1002/chin.199847204
https://doi.org/10.1002/chin.199847204
Autor:
Xuemei Liu, Joanna E. Burdette, Emily Pisha, Jiaqin Yao, Hong Liu, Steven M. Swanson, Fagen Zhang, Cassia R. Overk, Judy L. Bolton, Yan Li, Richard B. van Breemen
Publikováno v:
Chemical research in toxicology. 16(6)
Estrogen replacement therapy has been correlated with an increased risk for developing breast and endometrial cancers. One potential mechanism of estrogen carcinogenesis involves metabolism of estrogens to 2- and 4-hydroxylated catechols, which are f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861d901d28ce0556c6c8415b3b620ecc
https://pubmed.ncbi.nlm.nih.gov/12807357
https://pubmed.ncbi.nlm.nih.gov/12807357
Autor:
Xuemei Liu, Emily Pisha, Jiaqin Yao, Richard B. van Breemen, Yanan Yang, Judy L. Bolton, Yousheng Hua
Publikováno v:
Chemical research in toxicology. 15(4)
Excessive exposure to synthetic and endogenous estrogens has been associated with the development of cancer in several tissues. 4-Hydroxyequilenin (4-OHEN), a major metabolite of equine estrogens present in estrogen replacement formulations, has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ef194b0b81fbf49778d91a3a3de5bb
https://pubmed.ncbi.nlm.nih.gov/11952337
https://pubmed.ncbi.nlm.nih.gov/11952337
Publikováno v:
Chemical research in toxicology. 12(2)
The risk factors for women developing breast and endometrial cancers are all associated with a lifetime of estrogen exposure. Estrogen replacement therapy in particular has been correlated with a slight increased cancer risk. Previously, we showed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e6b74febe300a232b0ef1eff1a51ca
https://pubmed.ncbi.nlm.nih.gov/10027800
https://pubmed.ncbi.nlm.nih.gov/10027800