Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Emily Pierson"'
Autor:
Wim Bert Griet Schepens, Gilles Bignan, Leo Luistro, Sally Mahady, Monica Singer, Jocelyn Sendecki, Peter J. Connolly, James P. Edwards, Liam Campion, Kathryn Packman, Jan Willem Thuring, Hayley Ta, Nancy Bogdan, Shefali Patel, Caitlin Morgan, Daniel Jason Krosky, Emily Pierson, Glenn Van Aller, Melissa Smith, Thomas Wilde, Monicah A. Otieno, Michael J. Allegrezza, Heng-Keang Lim, Diana Wiley, Szeman Ruby Chan, Kim Staquet, Stuart L. Emanuel
Publikováno v:
Cancer Research. 80:5567A-5567A
The Stimulator of Interferon Genes (STING) protein is a key mediator of innate immunity that plays a central role in the immune response to invading pathogens (bacterial, viral) and transformed cells. A next generation human STING agonist, JNJ-‘619
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07931370687a649935a23154b8af8420
https://doi.org/10.1158/1538-7445.am2020-5567a
https://doi.org/10.1158/1538-7445.am2020-5567a
Publikováno v:
Nature Chemical Biology. 3:541-548
Clinically significant antibiotic resistance has evolved against virtually every antibiotic deployed. Yet the development of new classes of antibiotics has lagged far behind our growing need for such drugs. Rather than focusing on therapeutics that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24088576e0d94f5fedaaa53491d26fd6
https://doi.org/10.1038/nchembio.2007.24
https://doi.org/10.1038/nchembio.2007.24
Publikováno v:
Proceedings of the National Academy of Sciences. 104:2372-2377
The development of antimicrobials is critical in this time of increasing antibiotic resistance of most clinically relevant bacteria. To date, all current antibiotics focus on inhibiting crucial enzymatic activities of their protein targets (i.e., tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b43f123f9621deaaec7aedb4c5761dd
https://doi.org/10.1073/pnas.0611643104
https://doi.org/10.1073/pnas.0611643104
Publikováno v:
Science. 310:670-674
Increasing antibiotic resistance requires the development of new approaches to combating infection. Virulence gene expression in vivo represents a target for antibiotic discovery that has not yet been explored. A high-throughput, phenotypic screen wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128159d0b1f9ffdd4ef1fb3bfc5ea5fe
https://doi.org/10.1126/science.1116739
https://doi.org/10.1126/science.1116739
Autor:
Emily Pierson, Joan Goverman
Publikováno v:
The Journal of Immunology. 196:49.15-49.15
Myelin-specific CD4+ T cells initiate inflammation in the central nervous system during induction of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis. CD4+ T cell pathogenesis has been attributed to the secretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::400bcc3b9fa5580f66fb2b26df10921c
https://doi.org/10.4049/jimmunol.196.supp.49.15
https://doi.org/10.4049/jimmunol.196.supp.49.15
Publikováno v:
Immunological reviews. 248(1)
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by inflammatory, demyelinating lesions localized in the brain and spinal cord. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that is ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::433139c18005fc605e5fc4c23a956926
https://pubmed.ncbi.nlm.nih.gov/22725963
https://pubmed.ncbi.nlm.nih.gov/22725963
Publikováno v:
Magnetic resonance imaging. 22(1)
Lithium is used in the treatment and prophylaxis of manic-depressive illness. A narrow therapeutic range of lithium (0.4-1.2 meq/l) requires constant monitoring of these levels to avoid neurotoxicity and overdose. It is general practice to measure pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5debe517b8cdc18d3b932fda63e0e4df
https://pubmed.ncbi.nlm.nih.gov/14972401
https://pubmed.ncbi.nlm.nih.gov/14972401