Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

Autor: Noemia S. Lima, Maryam Musayev, Timothy S. Johnston, Danielle A. Wagner, Amy R. Henry, Lingshu Wang, Eun Sung Yang, Yi Zhang, Kevina Birungi, Walker P. Black, Sijy O’Dell, Stephen D. Schmidt, Damee Moon, Cynthia G. Lorang, Bingchun Zhao, Man Chen, Kristin L. Boswell, Jesmine Roberts-Torres, Rachel L. Davis, Lowrey Peyton, Sandeep R. Narpala, Sarah O’Connell, Leonid Serebryannyy, Jennifer Wang, Alexander Schrager, Chloe Adrienna Talana, Geoffrey Shimberg, Kwanyee Leung, Wei Shi, Rawan Khashab, Asaf Biber, Tal Zilberman, Joshua Rhein, Sara Vetter, Afeefa Ahmed, Laura Novik, Alicia Widge, Ingelise Gordon, Mercy Guech, I-Ting Teng, Emily Phung, Tracy J. Ruckwardt, Amarendra Pegu, John Misasi, Nicole A. Doria-Rose, Martin Gaudinski, Richard A. Koup, Peter D. Kwong, Adrian B. McDermott, Sharon Amit, Timothy W. Schacker, Itzchak Levy, John R. Mascola, Nancy J. Sullivan, Chaim A. Schramm, Daniel C. Douek

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Vaccines against the WA1 SARS-CoV2 strain confer protection against other variants. However, the mechanisms underlying cross-protection are not fully understood. Here, the authors develop a method for rapid analysis of single B cells from patient sam

Externí odkaz: https://doaj.org/article/b6d4d09b5933465b8ae8f4b440a22b6a

Epitope-Specific Serological Assays for RSV: Conformation Matters

Autor: Emily Phung, Lauren A. Chang, Kaitlyn M. Morabito, Masaru Kanekiyo, Man Chen, Deepika Nair, Azad Kumar, Grace L. Chen, Julie E. Ledgerwood, Barney S. Graham, Tracy J. Ruckwardt

Publikováno v: Vaccines, Vol 7, Iss 1, p 23 (2019)

Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in children and older adults. An effective vaccine must elicit neutralizing antibodies targeting the RSV fusion (F) protein, which exists in two major conformations, pre-fus

Externí odkaz: https://doaj.org/article/f0f63836d3ed411b93eda73d51fa2a8a

A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine

Autor: Lauren A. Chang, Emily Phung, Michelle C. Crank, Kaitlyn M. Morabito, Tonya Villafana, Filip Dubovsky, Judith Falloon, Mark T. Esser, Bob C. Lin, Grace L. Chen, Barney S. Graham, Tracy J. Ruckwardt

Publikováno v: Science translational medicine. 14(676)

There is currently no licensed vaccine for respiratory syncytial virus (RSV). Here, we assess the effect of RSV fusion protein (F) conformation on B cell responses in a post hoc comparison of samples from the DS-Cav1 [prefusion (pre-F)] and MEDI7510

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b812c6e5ca970c86f994ae6e96897819
https://pubmed.ncbi.nlm.nih.gov/36542692

Safety, tolerability, and immunogenicity of the respiratory syncytial virus prefusion F subunit vaccine DS-Cav1: a phase 1, randomised, open-label, dose-escalation clinical trial

Autor: Peifeng Chen, Anita Arthur, Kaitlyn M. Morabito, Kristin Leach, Xiaolin Wang, Grace L. Chen, Attila Nagy, Lauren A. Chang, Jon Cooper, Amy L. Chamberlain, Janel Holland-Linn, Olga Vasilenko, Alicia T. Widge, Shufeng Bai, Judith A Stein, LaSonji A. Holman, Cristina Carter, Iris Pittman, Deepika Gollapudi, Lisa A. Kueltzo, Colleen Fridley, Michelle C. Crank, Amritha Menon, William Whalen, Mridul Ghosh, Cynthia S. Hendel, Martha Nason, Amy Liu, Althaf Hussain, Laura Novik, Pernell Williams, Maria Burgos Florez, Robert T. Bailer, Thuy Nguyen, Brenda Larkin, Tracy J. Ruckwardt, Pamela Costner, Lam Le, Zhong Zhao, Elizabeth Carey, Vera Ivleva, Jennifer Walters, John R. Mascola, Jennifer Cunningham, Olga Trofymenko, Ya-chen Chang, Somia P. Hickman, Martin R. Gaudinski, Richard M. Schwartz, Slobodanka D. Manceva, Kevin Carlton, Barney S. Graham, Rahul Ragunathan, Jason G. D. Gall, Ana M. Ortega-Villa, Colin Tran, Sarah H. Plummer, Abidemi Ola, Ro Shauna S Rothwell, Ingelise J. Gordon, Mingzhong Chen, Jamie G. Saunders, Aba Mensima Eshun, Bob C. Lin, Azad Kumar, Nina M. Berkowitz, Xun Liu, Cora Trelles Cartagena, Emily Phung, Galina Yamshchikov, Joe Horwitz, Sarah O’Connell, Florence Kaltovich, Floreliz Mendoza, LaShawn Requilman, Man Chen, Preeti Apte, Christopher Lee, Renunda Hicks

Publikováno v: Lancet Respir Med

Multiple active vaccination approaches have proven ineffective in reducing the substantial morbidity and mortality caused by respiratory syncytial virus (RSV) in infants and older adults (aged ≥65 years). A vaccine conferring a substantial and sust

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ae60b574c97c5be6e3eabd0b1e70f3
https://doi.org/10.1016/s2213-2600(21)00098-9

Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants

Autor: Noemia S, Lima, Maryam, Mukhamedova, Timothy S, Johnston, Danielle A, Wagner, Amy R, Henry, Lingshu, Wang, Eun Sung, Yang, Yi, Zhang, Kevina, Birungi, Walker P, Black, Sijy, O'Dell, Stephen D, Schmidt, Damee, Moon, Cynthia G, Lorang, Bingchun, Zhao, Man, Chen, Kristin L, Boswell, Jesmine, Roberts-Torres, Rachel L, Davis, Lowrey, Peyton, Sandeep R, Narpala, Sarah, O'Connell, Jennifer, Wang, Alexander, Schrager, Chloe Adrienna, Talana, Kwanyee, Leung, Wei, Shi, Rawan, Khashab, Asaf, Biber, Tal, Zilberman, Joshua, Rhein, Sara, Vetter, Afeefa, Ahmed, Laura, Novik, Alicia, Widge, Ingelise, Gordon, Mercy, Guech, I-Ting, Teng, Emily, Phung, Tracy J, Ruckwardt, Amarendra, Pegu, John, Misasi, Nicole A, Doria-Rose, Martin, Gaudinski, Richard A, Koup, Peter D, Kwong, Adrian B, McDermott, Sharon, Amit, Timothy W, Schacker, Itzchak, Levy, John R, Mascola, Nancy J, Sullivan, Chaim A, Schramm, Daniel C, Douek

Publikováno v: bioRxiv : the preprint server for biology.

While humoral immune responses to infection or vaccination with ancestral SARS-CoV-2 have been well-characterized, responses elicited by infection with variants are less understood. Here we characterized the repertoire, epitope specificity, and cross

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9218e57258ea158f0fcb7c83fd7856b
https://pubmed.ncbi.nlm.nih.gov/35378757