Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Emily Pfeiffer"'
Autor:
Indroneal Banerjee, Jianlin Zhang, Thomas Moore-Morris, Emily Pfeiffer, Kyle S Buchholz, Ao Liu, Kunfu Ouyang, Matthew J Stroud, Larry Gerace, Sylvia M Evans, Andrew McCulloch, Ju Chen
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004114 (2014)
Recent interest has focused on the importance of the nucleus and associated nucleoskeleton in regulating changes in cardiac gene expression in response to biomechanical load. Mutations in genes encoding proteins of the inner nuclear membrane and nucl
Externí odkaz:
https://doaj.org/article/0ffa33f0b87146718f10ed4b4565896e
Autor:
Gintant, Gary, Kaushik, Emily Pfeiffer, Feaster, Tromondae, Stoelzle-Feix, Sonja, Kanda, Yasunari, Osada, Tomoharu, Smith, Godfrey, Czysz, Katherine, Kettenhofen, Ralf, Lu, Hua Rong, Cai, Beibei, Shi, Hong, Herron, Todd Joseph, Dang, Qianyu, Burton, Francis, Pang, Li, Traebert, Martin, Abassi, Yama, Pierson, Jennifer Beck, Blinova, Ksenia
Publikováno v:
In Regulatory Toxicology and Pharmacology November 2020 117
Autor:
Curtis Rambaran, Gary Gintant, Rhonda F. Rhyne, Victor Shi, Tanja S. Zabka, James L. Januzzi, Saumya Das, David E. Gutstein, Ellis F. Unger, Christopher Leptak, Jonathan H. Seltzer, Allan S. Jaffe, Ileana L. Piña, Thomas J. Povsic, Jacob A. Udell, Cyrus R. Mehta, Emily Pfeiffer Kaushik, John M. Canty, Maribel Salas, Christopher DeFilippi
Publikováno v:
Journal of the American College of Cardiology. 77:1922-1933
The momentum of cardiovascular drug development has slowed dramatically. Use of validated cardiac biomarkers in clinical trials could accelerate development of much-needed therapies, but biomarkers have been used less for cardiovascular drug developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f647eaea221c1fe1deaac2fc73692fa1
https://doi.org/10.1016/j.jacc.2021.02.040
https://doi.org/10.1016/j.jacc.2021.02.040
Autor:
Tomoharu Osada, Yama A. Abassi, Hong Shi, Jennifer B. Pierson, Sonja Stoelzle-Feix, Gary Gintant, Qianyu Dang, T.K. Feaster, Emily Pfeiffer Kaushik, Hua Rong Lu, Todd J. Herron, Li Pang, Ksenia Blinova, Godfrey L. Smith, Martin Traebert, Beibei Cai, Yasunari Kanda, Ralf Kettenhofen, Francis L. Burton, Katherine Czysz
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 117
Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models to study the electrophysiological effects of novel drug candidates on human ventricular repolarization. Two recent large validation studies have demonstrated the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20cfaa369b59aa16ea7b17cb1d749ec
https://pubmed.ncbi.nlm.nih.gov/32822771
https://pubmed.ncbi.nlm.nih.gov/32822771
Akademický článek
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Autor:
Kazunori Yamanaka, Tadahiro Shinozawa, Emily Pfeiffer Kaushik, Kazumasa Miyamoto, Toshikatsu Matsui, Kousuke Harada, Yoshiko Okai, Matthew Wagoner
Publikováno v:
Toxicology and applied pharmacology. 383
Recent developments of novel targeted therapies are contributing to the increased long-term survival of cancer patients; however, drug-induced cardiotoxicity induced by cancer drugs remains a serious problem in clinical settings. Nevertheless, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d33bb4b68bc93807aa81e6ea721f57
https://pubmed.ncbi.nlm.nih.gov/31533062
https://pubmed.ncbi.nlm.nih.gov/31533062
Autor:
Matthew Wagoner, Yoshiko Okai, Tadahiro Shinozawa, Keiko Matsune, Hiroshi Kohara, Emily Pfeiffer Kaushik, Kosuke Harada, Toshikatsu Matsui, Harushige Ozaki, Akimitsu Miyawaki, Kazunori Yamanaka
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106893
Introduction Drug-induced inotropic change is a risk factor in drug development; thus, de-risking is desired in the early stages of drug development. Unlike proarrhythmic risk assessment using human induced pluripotent stem cell-derived cardiomyocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d09293458704f9fe86a1f7b5669e79a
https://doi.org/10.1016/j.vascn.2020.106893
https://doi.org/10.1016/j.vascn.2020.106893
Autor:
Emily Pfeiffer Kaushik
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abf358fb3d3722e625fc5f21559b43db
https://doi.org/10.1016/j.vascn.2019.05.118
https://doi.org/10.1016/j.vascn.2019.05.118
Autor:
Yusu Gu, Emily Pfeiffer, Andrew D. McCulloch, Robert C. Lyon, Michael Y. Song, Marina Cerrone, Adam Wright, Melvin M. Scheinman, Valeria Mezzano, Steven J. Fowler, Sylvia M. Evans, Nancy D. Dalton, Kirk L. Peterson, Farah Sheikh, Yan Liang
Publikováno v:
Cardiovascular research, vol 111, iss 3
Aims Current mechanisms driving cardiac pacemaker function have focused on ion channel and gap junction channel function, which are essential for action potential generation and propagation between pacemaker cells. However, pacemaker cells also harbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651a580c9bb2f13873aa48987a892127
https://pubmed.ncbi.nlm.nih.gov/27325669
https://pubmed.ncbi.nlm.nih.gov/27325669
Autor:
Samuel T. Wall, Andrew D. McCulloch, Emily Pfeiffer, Joakim Sundnes, Bernardo Lino de Oliveira
Volume loading of the cardiac ventricles is known to slow electrical conduction in the rabbit heart, but the mechanisms remain unclear. Previous experimental and modeling studies have investigated some of these mechanisms, including stretch-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce47886b96565b70ae78e168aaeef27
https://europepmc.org/articles/PMC4830494/
https://europepmc.org/articles/PMC4830494/
