Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Emily P. Walker"'
Autor:
Christy W. LaFlamme, Cassandra Rastin, Soham Sengupta, Helen E. Pennington, Sophie J. Russ-Hall, Amy L. Schneider, Emily S. Bonkowski, Edith P. Almanza Fuerte, Talia J. Allan, Miranda Perez-Galey Zalusky, Joy Goffena, Sophia B. Gibson, Denis M. Nyaga, Nico Lieffering, Malavika Hebbar, Emily V. Walker, Daniel Darnell, Scott R. Olsen, Pandurang Kolekar, Mohamed Nadhir Djekidel, Wojciech Rosikiewicz, Haley McConkey, Jennifer Kerkhof, Michael A. Levy, Raissa Relator, Dorit Lev, Tally Lerman-Sagie, Kristen L. Park, Marielle Alders, Gerarda Cappuccio, Nicolas Chatron, Leigh Demain, David Genevieve, Gaetan Lesca, Tony Roscioli, Damien Sanlaville, Matthew L. Tedder, Sachin Gupta, Elizabeth A. Jones, Monika Weisz-Hubshman, Shamika Ketkar, Hongzheng Dai, Kim C. Worley, Jill A. Rosenfeld, Hsiao-Tuan Chao, Undiagnosed Diseases Network, Geoffrey Neale, Gemma L. Carvill, University of Washington Center for Rare Disease Research, Zhaoming Wang, Samuel F. Berkovic, Lynette G. Sadleir, Danny E. Miller, Ingrid E. Scheffer, Bekim Sadikovic, Heather C. Mefford
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Sequence-based genetic testing identifies causative variants in ~ 50% of individuals with developmental and epileptic encephalopathies (DEEs). Aberrant changes in DNA methylation are implicated in various neurodevelopmental disorders but rem
Externí odkaz:
https://doaj.org/article/56ab879163324f04934308a670c8a49d
Publikováno v:
Current Oncology, Vol 31, Iss 6, Pp 3073-3085 (2024)
Canada’s decentralized healthcare system may lead to regional disparities in survival among Canadians diagnosed with central nervous system (CNS) tumours. We identified 50,670 patients diagnosed with a first-ever primary CNS tumour between 2008 and
Externí odkaz:
https://doaj.org/article/f916e41a08e146a7b02eea005c35d24b
Autor:
Varun Kamat, Matthew K. Grumbine, Khang Bao, Kedar Mokate, Gamal Khalil, Daniel Cook, Brandon Clearwater, Richard Hirst, Jarrod Harman, Myriam Boeck, Zhongjie Fu, Lois E.H. Smith, Moloy Goswami, Thomas J. Wubben, Emily M. Walker, Jie Zhu, Scott A. Soleimanpour, Jarrad M. Scarlett, Brian M. Robbings, Daniel Hass, James B. Hurley, Ian R. Sweet
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 11, Pp 100642- (2023)
Summary: To address the needs of the life sciences community and the pharmaceutical industry in pre-clinical drug development to both maintain and continuously assess tissue metabolism and function with simple and rapid systems, we improved on the in
Externí odkaz:
https://doaj.org/article/3224701920bf49ea8c3bff2c8370db61
Publikováno v:
Current Oncology, Vol 30, Iss 4, Pp 4311-4328 (2023)
Primary central nervous system (CNS) tumours are heterogeneous, with different treatment pathways and prognoses depending on their histological and molecular classification. Due to their anatomical location, all CNS tumours, regardless of malignancy,
Externí odkaz:
https://doaj.org/article/0d7dd66aa2f045fb8528fb67eafc7367
Autor:
Jeeyeon Cha, Xin Tong, Emily M. Walker, Tehila Dahan, Veronica A. Cochrane, Sudipta Ashe, Ronan Russell, Anna B. Osipovich, Alex M. Mawla, Min Guo, Jin-hua Liu, Zachary A. Loyd, Mark O. Huising, Mark A. Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Type 2 diabetes (T2D) is associated with compromised identity of insulin-producing pancreatic islet β cells, characterized by inappropriate production of other islet cell–enriched hormones. Here, we examined how hormone misexpression was influence
Externí odkaz:
https://doaj.org/article/d8557c8689a94c42a21473f2861b2627
Autor:
Vaibhav Sidarala, Jie Zhu, Elena Levi-D’Ancona, Gemma L. Pearson, Emma C. Reck, Emily M. Walker, Brett A. Kaufman, Scott A. Soleimanpour
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Sidarala et al. examine the importance of the mitochondrial structural proteins, Mitofusins 1 and 2 (Mfn1/2), in diabetes. They find that Mfn1/2 control blood glucose by preserving mitochondrial DNA content, rather than mitochondrial structure.
Externí odkaz:
https://doaj.org/article/247caaeb45e74492958ffd5942fda4db
Publikováno v:
Current Oncology, Vol 29, Iss 3, Pp 2091-2105 (2022)
The incidence of BM among Canadian cancer patients is unknown. We aimed to estimate IP of BM at the time of cancer diagnosis and during the lifetime of patients with selected primary cancers. Data on BM at diagnosis from 2010–2017 was obtained from
Externí odkaz:
https://doaj.org/article/8009b562628247ea9adb676840cff481
Autor:
Engy A. Abdel-Rahman, Salma Hosseiny, Abdullah Aaliya, Mohamed Adel, Basma Yasseen, Abdelrahman Al-Okda, Yasmine Radwan, Saber H. Saber, Nada Elkholy, Eslam Elhanafy, Emily E. Walker, Juan P. Zuniga-Hertz, Hemal H. Patel, Helen R. Griffiths, Sameh S. Ali
Publikováno v:
Journal of Advanced Research, Vol 31, Iss , Pp 35-47 (2021)
Introduction: Incidents of myocardial infarction and sudden cardiac arrest vary with time of the day, but the mechanism for this effect is not clear. We hypothesized that diurnal changes in the ability of cardiac mitochondria to control calcium homeo
Externí odkaz:
https://doaj.org/article/5eaed48a125146708a2de0aabcb8bc0f
Publikováno v:
BMC Public Health, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Methylmercury contamination of the environment represents a substantial environmental health concern. Human exposure to methylmercury occurs primarily through consumption of fish and marine mammals. Heavily exposed subgroups inclu
Externí odkaz:
https://doaj.org/article/32f9fd6404754c369cbb58d0c516a7a3
Autor:
Ronan Russell, Phichitpol P. Carnese, Thomas G. Hennings, Emily M. Walker, Holger A. Russ, Jennifer S. Liu, Simone Giacometti, Roland Stein, Matthias Hebrok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The MAF bZIP transcription factor B (MAFB) is present in postnatal human beta cells but its role is unclear. Here, the authors show that MAFB regulates endocrine pancreatic cell fate specification.
Externí odkaz:
https://doaj.org/article/e0d2c3d6cf86401bb280695fe609017c