Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs

Autor: Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily P. S. Lam, Tatiana Lobry, Ron Wolchinsky, Angharad Lloyd, Katarzyna Ward, Eleanor M. Denham, Giulia Masi, Phyllis Tea Qing Yun, Colin Moore, Selsabil Dhaouadi, Gurdyal S. Besra, Natacha Veerapen, Patricia T. Illing, Julian P. Vivian, Jeremy M. Raynes, Jérôme Le Nours, Anthony W. Purcell, Samit Kundu, Jonathan D. Silk, Luke Williams, Sophie Papa, Jamie Rossjohn, Duncan Howie, Joseph Dukes

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundMajor histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection.

Externí odkaz: https://doaj.org/article/8f539e9eaf5e40e19fbc3e2c06f07574

Intradermal grass pollen immunotherapy increases T(H)2 and IgE responses and worsens respiratory allergic symptoms

Autor: Emily P. S. Lam, Anna Slovick, Joanna Kelly, Andrea Guerra, David J. Cousins, Stephen R. Durham, Mohamed H. Shamji, Janet L. Peacock, Konstantinos Tsioulos, Stephen J. Till, Sun Ying, Rachel Muir, Abdel Douiri, Evie Hay

Publikováno v: 1839.e13
Slovick, A, Douiri, A, Muir, R, Guerra, A, Tsioulos, K, Hay, E, Lam, E P S, Kelly, J, Peacock, J L, Sun, Y, Shamji, M H, Cousins, D J, Durham, S R & Till, S J 2017, ' Intradermal grass pollen immunotherapy increases T H 2 and IgE responses and worsens respiratory allergic symptoms ', Journal of Allergy and Clinical Immunology, vol. 139, no. 6, pp. 1830-1839 . https://doi.org/10.1016/j.jaci.2016.09.024
The Journal of Allergy and Clinical Immunology

Background: Repeated low-dose grass pollen intradermal allergen injection suppresses allergen-induced cutaneous late-phase responses comparably with conventional subcutaneous and sublingual immunotherapy. Objective: We sought to evaluate the efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dbb35ddac3594ce1d6de073c0b7af4
http://hdl.handle.net/10044/1/54652

A Randomized Placebo-Controlled Trial of Intradermal Grass Pollen Immunotherapy for Seasonal Allergic Rhinitis

Autor: Sun Ying, Janet L. Peacock, Abdel Douiri, Rachel Muir, Mohamed H. Shamji, Stephen J. Till, Andrea Guerra, David J. Cousins, Joanna Kelly, Kostas Tsioulos, Stephen R. Durham, Emily P. S. Lam, Anna Slovick, Evie Haye

Publikováno v: Journal of Allergy and Clinical Immunology. 137:AB94

Rationale: We previously reported that repeated intradermal injection of grass pollen (nanograms of allergen) almost completely suppresses allergen-induced cutaneous late phase responses (JACI 2012 130(4):918-24). Similar suppression of late response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::034b05400dbc13f386147f8ccce49b55
https://doi.org/10.1016/j.jaci.2015.12.433