Výsledky vyhledávání - "Emily N. Pierce"

Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases

Autor: Margaret Y. Kawarski, Rachel C. Knopp, Gena Lenti, Magdalena Bryja, Bhabna Pati, Victor Ceja, D. Eric Walters, Caitlin E. Karver, Helen A. Gustafson, Courtney R. Kent, Emily N. Pierce

Publikováno v: Bioorganicmedicinal chemistry letters. 26(22)

The inflammatory caspases (caspase-1, -4 and -5) are potential therapeutic targets for autoimmune and inflammatory diseases due to their involvement in the immune response upon inflammasome formation. A series of small molecules based on the 4-(piper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5524e192b9bca91bdf023eb996cf40cd
https://pubmed.ncbi.nlm.nih.gov/27777011

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Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome

Autor: Emily N. Pierce, Vladislav A. Litosh, Gregory R. J. Thatcher, Yue-Ting Wang, Marton I. Siklos, Sujeewa C. Piyankarage, Tareisha L. Dunlap

Publikováno v: Chemical research in toxicology. 29(7)

Electrophilic reactive intermediates resulting from drug metabolism have been associated with toxicity and off-target effects and in some drug discovery programs trigger NO-GO decisions. Many botanicals and dietary supplements are replete with such r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553c764f7b9caf06b85361980bc18981
https://pubmed.ncbi.nlm.nih.gov/27258437

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