Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Emily N Reinke"'
Autor:
Emily N. Reinke, Joe Reynolds, Nicola Gilmour, Georgia Reynolds, Judy Strickland, Dori Germolec, David G. Allen, Gavin Maxwell, Nicole C. Kleinstreuer
Publikováno v:
Current Research in Toxicology, Vol 8, Iss , Pp 100205- (2025)
Mechanistically based non-animal methods for assessing skin sensitization hazard have been developed, but are not considered sufficient, individually, to conclusively define the skin sensitization potential or potency of a chemical. This resulted in
Externí odkaz:
https://doaj.org/article/3fb7d79eee2d4b0da7cd5b1c2c4c7f88
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93472 (2014)
Glutathione peroxidase activity was previously determined to be elevated in lymphocytes obtained from patients treated with the Bcr-Abl kinase inhibitor imatinib mesylate. In order to expand upon this observation, the established chronic myelogenous
Externí odkaz:
https://doaj.org/article/9519fcc58f42467885e27e1ce7ec5b93
Autor:
Xiaoqing Chang, Yu-Mei Tan, David G. Allen, Shannon Bell, Paul C. Brown, Lauren Browning, Patricia Ceger, Jeffery Gearhart, Pertti J. Hakkinen, Shruti V. Kabadi, Nicole C. Kleinstreuer, Annie Lumen, Joanna Matheson, Alicia Paini, Heather A. Pangburn, Elijah J. Petersen, Emily N. Reinke, Alexandre J. S. Ribeiro, Nisha Sipes, Lisa M. Sweeney, John F. Wambaugh, Ronald Wange, Barbara A. Wetmore, Moiz Mumtaz
Publikováno v:
Toxics, Vol 10, Iss 5, p 232 (2022)
During the past few decades, the science of toxicology has been undergoing a transformation from observational to predictive science. New approach methodologies (NAMs), including in vitro assays, in silico models, read-across, and in vitro to in vivo
Externí odkaz:
https://doaj.org/article/4550eafa6f01496abb0f462601d930e4
Autor:
Abigail Jacobs, David R. Mattie, Suzanne Fitzpatrick, Anna Lowit, David Allen, Jeffrey Brown, Joanna Matheson, Emily N. Reinke, Warren Casey, Surender Ahir, Judy Strickland, Amy J. Clippinger, Nicole Kleinstreuer, Mark S. Johnson, Michael J. Quinn
Publikováno v:
Regulatory Toxicology and Pharmacology. 94:183-196
Acute systemic toxicity data are used by a number of U.S. federal agencies, most commonly for hazard classification and labeling and/or risk assessment for acute chemical exposures. To identify opportunities for the implementation of non-animal appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b9add5099e80912283fe1ef93eae03
https://doi.org/10.1016/j.yrtph.2018.01.022
https://doi.org/10.1016/j.yrtph.2018.01.022
Publikováno v:
Regul Toxicol Pharmacol
Perchlorate is an important oxidizer used in propellants, pyrotechnics, and as a gas generator in commercial airbags, fireworks, and roadside flares. It is highly water soluble, interferes with thyroidal iodide uptake and is an environmental contamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99197df061518a480849989b10fb8c6
https://pubmed.ncbi.nlm.nih.gov/31884155
https://pubmed.ncbi.nlm.nih.gov/31884155
Autor:
Naomi Hudson, Abigail Jacobs, Surender Ahir, Amber B. Daniel, Emily N. Reinke, Cecilia Aguila, Joanna Matheson, Judy Strickland, Simona Bancos, David M. Lehmann, Stanislav Vukmanovic, Evisabel Craig, David Allen, Dori R. Germolec, Chandramallika Ghosh, Nakissa Sadrieh, Nicole Kleinstreuer
United States regulatory and research agencies may rely upon skin sensitization test data to assess the sensitization hazards associated with dermal exposure to chemicals and products. These data are evaluated to ensure that such substances will not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ec0856875aeac992204463a7947d88
https://europepmc.org/articles/PMC6363849/
https://europepmc.org/articles/PMC6363849/
Autor:
Lawrence Milchak, Jane Rose, Sheung P. Ng, Monita Sharma, Kyle P. Glover, Jodie Melbourne, Alicia Paini, Kathryn Page, Wayne Spoo, Annie M. Jarabek, Brian Keyser, Hans Raabe, Peter S. Thorne, Lan Ma-Hock, Anna G. Maione, Jon A. Hotchkiss, Daniel M. Wilson, Patrudu S. Makena, Clive Roper, Kelly Ann Berube, Sean C. Gehen, Paul M. Hinderliter, Anita R. Iskandar, Patrick Hayden, David Allen, Emily N. Reinke, Amy J. Clippinger, Marianna Gaça, Michael B. Bolger, Holger Behrsing, Warren Casey, Karsta Luettich, Grace Patlewicz, Pilar Prieto, Michael DeLorme
New approaches are needed to assess the effects of inhaled substances on human health. These approaches will be based on mechanisms of toxicity, an understanding of dosimetry, and the use of in silico modeling and in vitro test methods. In order to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad61ae01e0ad0fe9a756ec6ecb363f88
This chapter presents the wildlife toxicity assessment for nitroguanidine (NQ), a stable explosive compound used as a propellant in cartridges. This wildlife toxicity assessment addresses only toxicity to mammals, as data for amphibians, reptiles, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86e71f0f5617eaa9947c3f43b2b9be3d
https://doi.org/10.1016/b978-0-12-800020-5.00007-7
https://doi.org/10.1016/b978-0-12-800020-5.00007-7
Biomedical, toxicological, and ecological databases were searched for reports and studies about the toxicology of the pesticide aldrin on wildlife (mammals, birds, reptiles, and amphibians). Citations were evaluated for biologically relevant endpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead68038aecb9a6dfa27b13f32ba9da9
https://doi.org/10.1016/b978-0-12-800020-5.00021-1
https://doi.org/10.1016/b978-0-12-800020-5.00021-1
Autor:
Emily N. Reinke, Adam T. Deck
This chapter presents the wildlife toxicity assessment (WTA) for chlordane, an organochlorine pesticide that was widely used in the U.S. from 1947 to 1978. Its use was curtailed following an increased concern about its cancer-causing effects, and it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddaca252d5ecf2de996e20fc23fd437c
https://doi.org/10.1016/b978-0-12-800020-5.00022-3
https://doi.org/10.1016/b978-0-12-800020-5.00022-3