Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Emily Miyoshi"'
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S931- (2023)
Externí odkaz:
https://doaj.org/article/b347a0c192964f9ea210e61c0d5b29bc
Autor:
Ryan G. Lim, Osama Al-Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Richard A. Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu Michael, Nicolette McClure, Xena E. Flowers, Jean Paul Vonsattel, Shawn Davidson, Vilas Menon, Vivek Swarup, Ernest Fraenkel, James E. Goldman, Leslie M. Thompson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Here the authors evaluate single cell gene expression from mouse and human Huntington’s disease brains, finding incomplete oligodendrocyte maturation and pathways involved. Treating mice with thiamine/biotin ameliorates molecular pathology.
Externí odkaz:
https://doaj.org/article/3ad164ee693049358f658929a36c0698
Autor:
Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns, Jie Wu, Sarah J. Hernandez, Nicolette McClure, Keona Q. Wang, Corey J. Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, David Van Vactor, John C. Reidling, Mathew Blurton-Jones, Vivek Swarup, Wayne W. Poon, Ryan G. Lim, Leslie M. Thompson
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105732- (2023)
Summary: Huntington disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene that alters cellular homeostasis, particularly in the striatum and cortex. Astrocyte signaling that establishes and maintains neuro
Externí odkaz:
https://doaj.org/article/3051cef5c5b24f3ebdab019b1d8be6cf
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101491- (2022)
Summary: Single-nucleus ATAC sequencing (snATAC-seq) employs a hyperactive Tn5 transposase to gain precise information about the cis-regulatory elements in specific cell types. However, the standard protocol of snATAC-seq is not optimized for all tis
Externí odkaz:
https://doaj.org/article/e1ed435d526a45d2b976c68aa8bcda72
Autor:
Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C. Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A. Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jones
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110961- (2022)
Summary: Microglia are strongly implicated in the development and progression of Alzheimer’s disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetica
Externí odkaz:
https://doaj.org/article/def9c689b7ba47e59182ba5cb0a6929b
Publikováno v:
Neurobiology of Disease, Vol 160, Iss , Pp 105530- (2021)
Over the years, genetic studies have identified multiple genetic risk variants associated with neurodegenerative disorders and helped reveal new biological pathways and genes of interest. However, genetic risk variants commonly reside in non-coding r
Externí odkaz:
https://doaj.org/article/b39aa0579d54490483c93a0a58d0f295
Autor:
Emily Miyoshi, Vivek Swarup
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 12, Pp 2415-2416 (2021)
Externí odkaz:
https://doaj.org/article/2bd9545aea3344009273c460266a5c8f
Autor:
Emily Miyoshi, Samuel Morabito, Caden M Henningfield, Neethu Michael, Sepideh Kiani Shabestari, Sudeshna Das, Saba Shahin, MODEL AD, Kim N Green, Vivek Swarup
Publikováno v:
Alzheimer's & Dementia. 18
Biological systems are immensely complex, organized into a multi-scale hierarchy of functional units based on tightly-regulated interactions between distinct molecules, cells, organs, and organisms. While experimental methods enable transcriptome-wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6f38d35e7b32712f189fd8558c946b6
https://doi.org/10.1101/2022.09.22.509094
https://doi.org/10.1101/2022.09.22.509094
Autor:
Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns, Jie Wu, Sarah J. Hernandez, Nicolette Geller, Keona Q. Wang, Corey Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, Mathew Blurton-Jones, David Van Vactor, John C. Reidling, Vivek Swarup, Wayne W. Poon, Ryan G. Lim, Leslie M. Thompson
SummaryHuntington’s disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat within the Huntingtin (HTT) gene having dysregulated cellular homeostasis in the central nervous system, particularly in the striatum and cortex. Astro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d177766042f0b16d1d266c4d2914e4d5
https://doi.org/10.1101/2022.07.28.501170
https://doi.org/10.1101/2022.07.28.501170