Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Emily McFall"'
Autor:
Katharina E. Meijboom, Emma R. Sutton, Eve McCallion, Emily McFall, Daniel Anthony, Benjamin Edwards, Sabrina Kubinski, Ines Tapken, Ines Bünermann, Gareth Hazell, Nina Ahlskog, Peter Claus, Kay E. Davies, Rashmi Kothary, Matthew J. A. Wood, Melissa Bowerman
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-25 (2022)
Abstract Background Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is characterized by the selective death of spinal cord motor neurons, leading to progressive m
Externí odkaz:
https://doaj.org/article/a0412765d08744319f58479db82da5ff
Autor:
Lisa M. Walter, Marc-Olivier Deguise, Katharina E. Meijboom, Corinne A. Betts, Nina Ahlskog, Tirsa L.E. van Westering, Gareth Hazell, Emily McFall, Anna Kordala, Suzan M. Hammond, Frank Abendroth, Lyndsay M. Murray, Hannah K. Shorrock, Domenick A. Prosdocimo, Saptarsi M. Haldar, Mukesh K. Jain, Thomas H. Gillingwater, Peter Claus, Rashmi Kothary, Matthew J.A. Wood, Melissa Bowerman
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 226-242 (2018)
The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is
Externí odkaz:
https://doaj.org/article/849c74dffc964c96a18e513e6677d66c
Autor:
Melissa Bowerman, Kay E. Davies, Emily McFall, Benjamin Edwards, Rashmi Kothary, Daniel C. Anthony, Nina Ahlskog, Matthew J.A. Wood, Sabrina Kubinski, Katharina E. Meijboom, G Hazell, Peter Claus
Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is characterized by the selective death of spinal cord motor neurons, leading to progressive muscle wasting. Loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::914fe2d1b3bff85694df3640d35e3875
https://doi.org/10.1101/2021.09.13.460053
https://doi.org/10.1101/2021.09.13.460053
Autor:
Lyndsay M. Murray, Katharina E. Meijboom, Emily McFall, Tirsa L.E. van Westering, Suzan M. Hammond, Domenick A. Prosdocimo, Thomas H. Gillingwater, Marc-Olivier Deguise, Melissa Bowerman, Rashmi Kothary, Corinne A. Betts, Nina Ahlskog, G Hazell, Matthew J.A. Wood, Frank Abendroth, Hannah K. Shorrock, Anna Kordala, Mukesh K. Jain, Saptarsi M. Haldar, Lisa Marie Walter, Peter Claus
Publikováno v:
EBioMedicine
Walter, L M, Deguise, M-O, Meijboom, K E, Betts, C A, Ahlskog, N, van Westering, T L E, Hazell, G, McFall, E, Kordala, A, Hammond, S M, Abendroth, F, Murray, L, Shorrock, H K, Prosdocimo, D A, Haldar, S M, Jain, M K, Gillingwater, T, Claus, P, Kothary, R, Wood, M J A & Bowerman, M 2018, ' Interventions targeting glucocorticoid-Krüppel-like factor 15-branched-chain amino acid signaling improve disease phenotypes in spinal muscular atrophy mice ', EBioMedicine . https://doi.org/10.1016/j.ebiom.2018.04.024
EBioMedicine, Vol 31, Iss, Pp 226-242 (2018)
Walter, L M, Deguise, M-O, Meijboom, K E, Betts, C A, Ahlskog, N, van Westering, T L E, Hazell, G, McFall, E, Kordala, A, Hammond, S M, Abendroth, F, Murray, L, Shorrock, H K, Prosdocimo, D A, Haldar, S M, Jain, M K, Gillingwater, T, Claus, P, Kothary, R, Wood, M J A & Bowerman, M 2018, ' Interventions targeting glucocorticoid-Krüppel-like factor 15-branched-chain amino acid signaling improve disease phenotypes in spinal muscular atrophy mice ', EBioMedicine . https://doi.org/10.1016/j.ebiom.2018.04.024
EBioMedicine, Vol 31, Iss, Pp 226-242 (2018)
The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is
Autor:
Lyndsay M. Murray, John A. Lunde, Rashmi Kothary, Emily McFall, Robin J. Parks, Bernard J. Jasmin
Publikováno v:
Virology. :444-453
We have investigated whether reducing the overall size of adenovirus (Ad), through use of a vector containing a shortened fibre, leads to enhanced distribution and dissemination of the vector. Intravenous or intraperitoneal injection of Ad5SlacZ (12n
Autor:
Rashmi Kothary, Nicole Auclair, Emily McFall, Marc-Olivier Deguise, Subash Sad, Yves De Repentigny
Publikováno v:
Human Molecular Genetics
Spinal muscular atrophy (SMA) has long been solely considered a neurodegenerative disorder. However, recent work has highlighted defects in many other cell types that could contribute to disease aetiology. Interestingly, the immune system has never b
Autor:
A. Tiernay, Y. De Repentigny, Ariane Beauvais, Emily McFall, B. Paul, Marc-Olivier Deguise, Rashmi Kothary
Publikováno v:
Neuromuscular Disorders. 28:S57
Publikováno v:
Biochemistry and Cell Biology. 91:252-264
Spinal muscular atrophy (SMA) is the most common inherited neurodegenerative disease that leads to infant mortality. It is caused by mutations in the survival motor neuron (SMN) protein resulting in death of alpha motor neurons. Increasing evidence s
Publikováno v:
Viruses, Vol 5, Iss 6, Pp 1500-1515 (2013)
Viruses
Viruses
Vectors based on adenovirus (Ad) are one of the most commonly utilized platforms for gene delivery to cells in molecular biology studies and in gene therapy applications. Ad is also the most popular vector system in human clinical gene therapy trials
Publikováno v:
Human Molecular Genetics
Spinal muscular atrophy (SMA) is caused by mutations or deletions in the Survival Motor Neuron 1 (SMN1) gene in humans. Modifiers of the SMA symptoms have been identified and genetic background has a substantial effect in the phenotype and survival o