Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Emily Makowski"'
Autor:
Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter M. Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Lee et al. report an engineered IgG1 Fc domain that behaves like an hFcRn binding pH toggle switch. The authors show that this new half-life extension Fc domain confers improved pharmacokinetics in new humanized knock-in mouse strains that recapitula
Externí odkaz:
https://doaj.org/article/84d23b07351d4847b7e49dca2fbb568c
Autor:
Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter M. Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/8c4e20eedae3439a812a8b79401a3610
Autor:
Ariel Tennenhouse, Lev Khmelnitsky, Razi Khalaila, Noa Yeshaya, Ashish Noronha, Moshit Lindzen, Emily Makowski, Ira Zaretsky, Yael Fridmann Sirkis, Yael Galon-Wolfenson, Peter M. Tessier, Jakub Abramson, Yosef Yarden, Deborah Fass, Sarel J. Fleishman
Humanization is an essential step in developing animal-derived antibodies into therapeutics, and approximately one third of approved antibodies have been humanized. Conventional humanization approaches graft the complementarity-determining regions (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::035c82beebe5e97b06e0fdd86324b028
https://doi.org/10.1101/2022.08.14.503891
https://doi.org/10.1101/2022.08.14.503891
