Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier

Autor: John J. Garber, Emily M. Mallick, Karen M. Scanlon, Jerrold R. Turner, Michael S. Donnenberg, John M. Leong, Scott B. Snapper

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 273-288 (2018)

Neural Wiskott-Aldrich Syndrome protein (N-WASP) is a key regulator of the actin cytoskeleton in epithelial tissues and is poised to mediate cytoskeletal-dependent aspects of apical junction complex (AJC) homeostasis. Attaching-and-effacing (AE) path

Externí odkaz: https://doaj.org/article/d26c868dc14c44258353e4ebc05e513c

Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier

Autor: Michael S. Donnenberg, Karen M. Scanlon, John J. Garber, Scott B. Snapper, Jerrold R. Turner, Emily M. Mallick, John M. Leong

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 273-288 (2018)

Background & Aims Neural Wiskott-Aldrich Syndrome protein (N-WASP) is a key regulator of the actin cytoskeleton in epithelial tissues and is poised to mediate cytoskeletal-dependent aspects of apical junction complex (AJC) homeostasis. Attaching-and-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28760ed63e5fd5a3479481b0b279b85
https://doi.org/10.1016/j.jcmgh.2017.11.015

The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment

Autor: Emily M, Mallick, John J, Garber, Vijay K, Vanguri, Sowmya, Balasubramanian, Timothy, Blood, Stacie, Clark, Didier, Vingadassalom, Christopher, Louissaint, Beth, McCormick, Scott B, Snapper, John M, Leong

Publikováno v: Cellular microbiology. 16(9)

Enterohemorrhagic Escherichia coli (EHEC) adheres to intestinal epithelial cells, then stimulates the actin nucleation promoting factor N-WASP to induce localized actin assembly resulting in an actin “pedestal”, the function of which is poorly un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7965024bd477724fff24aefb61d4780
https://pubmed.ncbi.nlm.nih.gov/24780054

List of Contributors

Autor: Sowmya Balasubramanian, Cedric N. Berger, Julien R.C. Bergeron, Nadia Boisen, Sujay Chattopadhyay, Abigail Clements, Leon G. De Masi, Mauricio J. Farfan, James M. Fleckenstein, Gad Frankel, Victor A. Garcia-Angulo, David M. Gordon, Ian R. Henderson, Scott J. Hultgren, Dakshina M. Jandhyala, Vasilios Kalas, Kwang Sik Kim, Karen A. Krogfelt, John M. Leong, Joshua A. Lieberman, Mariella Lomma, Emily M. Mallick, Anthony T. Maurelli, Harry L.T. Mobley, Carolyn R. Morris, James P. Nataro, Shahista Nisa, David A. Rasko, Jason W. Sahl, Karen M. Scanlon, Evgeni V. Sokurenko, Rachel R. Spurbeck, Natalie C.J. Strynadka, Courntey D. Sturey, Alfredo G. Torres, Sivapriya Kailasan Vanaja, Ender Volkan, Timothy J. Wells, Chris Whitfield, Lisa M. Willis, Liam J. Worrall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32fb61c43a0524ad5744ae0ce487a383
https://doi.org/10.1016/b978-0-12-397048-0.01002-0

Allele- and tir-independent functions of intimin in diverse animal infection models

Autor: Emily M Mallick, Michael John Brady, Steven A Luperchio, Vijay eVanguri, Loranne eMagoun, Hui eLiu, Barbara J Sheppard, Jean eMukherjee, Arthur eDonohue-Rolfe, Saul eTzipori, John M Leong, David B Schauer

Publikováno v: Frontiers in Microbiology
Frontiers in Microbiology, Vol 3 (2012)

Upon binding to intestinal epithelial cells, enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli (EPEC), and Citrobacter rodentium trigger formation of actin pedestals beneath bound bacteria. Pedestal formation has been associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3d9a47be184905121a84f3f54f3e49
https://pubmed.ncbi.nlm.nih.gov/22347213