Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Emily M. Lee"'
Autor:
Caroline E. Strong, Jiajing Zhang, Martin Carrasco, Srikanya Kundu, Molly Boutin, Harshad D. Vishwasrao, Jiamin Liu, Angelica Medina, Yu-Chi Chen, Kelli Wilson, Emily M. Lee, Marc Ferrer
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract 3D spheroids have emerged as powerful drug discovery tools given their high-throughput screening (HTS) compatibility. Here, we describe a method for generating functional neural spheroids by cell-aggregation of differentiated human induced p
Externí odkaz:
https://doaj.org/article/f3586b8c452a49948ce8a41970b8c9ec
Autor:
Hoda Zarkoob, Anna Allué-Guardia, Yu-Chi Chen, Andreu Garcia-Vilanova, Olive Jung, Steven Coon, Min Jae Song, Jun-Gyu Park, Fatai Oladunni, Jesse Miller, Yen-Ting Tung, Ivan Kosik, David Schultz, James Iben, Tianwei Li, Jiaqi Fu, Forbes D. Porter, Jonathan Yewdell, Luis Martinez-Sobrido, Sara Cherry, Jordi B. Torrelles, Marc Ferrer, Emily M. Lee
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Human alveolar and tracheobronchial epithelial air liquid interface (ALI) tissues are used as models to examine cellular responses to SARS-CoV-2 and influenza A virus infections and as antiviral drug screening assay platforms.
Externí odkaz:
https://doaj.org/article/003ca60ed064430890c5954d0c4a6343
Autor:
Guang Song, Emily M. Lee, Jianbo Pan, Miao Xu, Hee-Sool Rho, Yichen Cheng, Nadia Whitt, Shu Yang, Jennifer Kouznetsova, Carleen Klumpp-Thomas, Samuel G. Michael, Cedric Moore, Ki-Jun Yoon, Kimberly M. Christian, Anton Simeonov, Wenwei Huang, Menghang Xia, Ruili Huang, Madhu Lal-Nag, Hengli Tang, Wei Zheng, Jiang Qian, Hongjun Song, Guo-li Ming, Heng Zhu
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 4, Pp 808-809 (2022)
Externí odkaz:
https://doaj.org/article/3d5fe2b25f014bd9a48ec957e2e5487d
Autor:
Kirill Gorshkov, Ni Sima, Wei Sun, Billy Lu, Wei Huang, Jameson Travers, Carleen Klumpp-Thomas, Samuel G. Michael, Tuan Xu, Ruili Huang, Emily M. Lee, Xiaodong Cheng, Wei Zheng
Publikováno v:
Translational Oncology, Vol 12, Iss 3, Pp 441-452 (2019)
Heterogeneous response to chemotherapy is a major issue for the treatment of cancer. For most gynecologic cancers including ovarian, cervical, and placental, the list of available small molecule therapies is relatively small compared to options for o
Externí odkaz:
https://doaj.org/article/e373e75cdaf24232b5787dfac7788c08
Autor:
Shu Yang, Kirill Gorshkov, Emily M. Lee, Miao Xu, Yu-Shan Cheng, Nuo Sun, Ferri Soheilian, Natalia de Val, Guoli Ming, Hongjun Song, Hengli Tang, Wei Zheng
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The 2015 to 2016 outbreak of Zika virus (ZIKV) infections in the Americas coincided with a dramatic increase in neurodevelopmental abnormalities, including fetal microcephaly, in newborns born to infected women. In this study, we observed mitochondri
Externí odkaz:
https://doaj.org/article/9b62b642d6664fefa85116988315a422
Autor:
Catherine Z. Chen, Wei Zheng, Manisha Pradhan, Miao Xu, Emily M. Lee, Shu Yang, Kirill Gorshkov, Min Shen
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
High-throughput cell-based fluorescent imaging assays often require removal of background fluorescent signal to obtain robust measurements. Processing high-density microplates to remove background signal is challenging because of equipment requiremen
Autor:
Ying Fu, Juliana da Fonseca Rezende e Mello, Bryan D. Fleming, Alex Renn, Catherine Z. Chen, Xin Hu, Miao Xu, Kirill Gorshkov, Quinlin Hanson, Wei Zheng, Emily M. Lee, Lalith Perera, Robert Petrovich, Manisha Pradhan, Richard T. Eastman, Zina Itkin, Thomas B. Stanley, Allen Hsu, Venkata Dandey, Kedar Sharma, William Gillette, Troy Taylor, Nitya Ramakrishnan, Shelley Perkins, Dominic Esposito, Eunkeu Oh, Kimihiro Susumu, Mason Wolak, Marc Ferrer, Matthew D. Hall, Mario J. Borgnia, Anton Simeonov
Publikováno v:
bioRxiv
Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobody construc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e229c55e6f9f11419c5c35925abed82
https://doi.org/10.1101/2021.10.22.465476
https://doi.org/10.1101/2021.10.22.465476
Autor:
Matthew B. Frieman, Samuel Constant, Lauren Castellana, Stuart Weston, Carly Dillen, Sara Cherry, Holly L. Hammond, Kanupriya Whig, Marc Ferrer, Kasirajan Ayyanathan, Robert Johnson, Mark Dittmar, Christoph A. Thaiss, Emily M. Lee, Jesse Miller, Jae Seung Lee, Minghua Li, David C. Schultz, Brinda Kamalia
Publikováno v:
bioRxiv
The ongoing COVID-19 pandemic has highlighted the dearth of approved drugs to treat viral infections, with only ∼90 FDA approved drugs against human viral pathogens. To identify drugs that can block SARS-CoV-2 replication, extensive drug screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86b5c3b86d13d1d1c4f9c3ba1580f19
https://doi.org/10.1101/2021.06.24.449811
https://doi.org/10.1101/2021.06.24.449811
Autor:
Holly Ramage, Christoph A. Thaiss, Minghua Li, Kristen W. Lynch, Max Ferretti, Hélène Descamps, Yu-Chi Chen, Kanupriya Whig, Hoda Zarkoob, David C. Schultz, Marc Ferrer, Emily M. Lee, Mark Dittmar, Baoling Ying, Brinda Kamalia, Sara Cherry, Lenka Dohnalová, Jae Seung Lee, Michael S. Diamond, Giulia T. Uhr
Publikováno v:
Sci Immunol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic, resulting millions of infections and deaths with few effective interventions available. Here, we demonstrate that SARS-CoV-2 evades interferon (IFN) activation
Autor:
Hoda Zarkoob, Anna Allué-Guardia, Yu-Chi Chen, Andreu Garcia-Vilanova, Olive Jung, Steven Coon, Min Jae Song, Jun-Gyu Park, Fatai Oladunni, Jesse Miller, Yen-Ting Tung, Ivan Kosik, David Schultz, James Iben, Tianwei Li, Jiaqi Fu, Forbes D. Porter, Jonathan Yewdell, Luis Martinez-Sobrido, Sara Cherry, Jordi B. Torrelles, Marc Ferrer, Emily M. Lee
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third coronavirus in less than 20 years to spillover from an animal reservoir and cause severe disease in humans. High impact respiratory viruses such as pathogenic beta-coronaviruse