Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Emily M. Kugler"'
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CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
Autor: Divij Mathew, Laura A. Vella, Randall A. Oyer, Jedd D. Wolchok, James Robinson, Cécile Alanio, Susan DeWolf, Kara N. Maxwell, Amy E. Baxter, Erin Bange, Karan Naik, Scott E. Hensley, Justin Kim, Anita Kumar, Tara Perloff, Adam J Widman, Madison E. Weirick, Santosha Vardhana, Madeline A Hwee, Florence Porterfield, Derek A. Oldridge, Krista R Budzik, Samuel J Kerr, Justine V. Cohen, Nicholas Han, Josephine R. Giles, Christopher M McAllister, Ariel R. Weisman, Michael Galantino, Angela DeMichele, Ivan Maillard, Charlotte Roberts, Caroline A. G. Ittner, Paul Wileyto, Ronac Mamtani, Lova Sun, Susan Tollett, Jennifer E. Wu, Olutosin Owoyemi, Sharon Adamski, John P. Reilly, Alexander C. Huang, Sigrid Gouma, Ryan Massa, Allison R. Greenplate, Sawsan R. Boutemine, E. John Wherry, Heather M. Giannini, Tiffanie K. Jones, Carla Wright, Olutwatosin Oniyide, Emily M. Kugler, N. Esther Babady, Alfred L. Garfall, Peter Maslak, Robert H. Vonderheide, Cathy Zheng, R.S. Agyekum, Nuala J. Meyer, Thomas G. Dunn
Publikováno v: Nature Medicine. 27:1280-1289
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients with cancer who were hospitalized for COVID-19, patients with hema
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::953c384aa17e1a2d15af5f6dd7fec305
https://doi.org/10.1038/s41591-021-01386-7
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3
Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7
Autor: Nathan H. Roy, Laurence Berry, Emily M. Kugler, Jung-Bum Shin, Boris Striepen, Janis K. Burkhardt, Amandine Guérin
Publikováno v: Cell Host Microbe
Summary The parasite Cryptosporidium invades and replicates in intestinal epithelial cells and is a leading cause of diarrheal disease and early childhood mortality. The molecular mechanisms that underlie infection and pathogenesis are largely unknow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2067545a8d0f2a5fa95fd224583be2b6
https://europepmc.org/articles/PMC8475647/
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5
CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer
Autor: Lova Sun, Derek A. Oldridge, Thomas G. Dunn, M. Galantino, Ronac Mamtani, T. Perloff, Anita Kumar, Nicholas Han, Nuala J. Meyer, Peter Maslak, C. Roberts, Santosha Vardhana, Ariel R. Weisman, Caroline A. G. Ittner, Adam J Widman, Randall A. Oyer, E. Wherry, S. Kerr, Divij Mathew, Angela DeMichele, Christopher M McAllister, Amy E. Baxter, Ivan Maillard, C. Wright, Jedd D. Wolchok, James Robinson, Justine V. Cohen, Cécile Alanio, Susan DeWolf, Allison R. Greenplate, K. Budzik, Kara N. Maxwell, Scott E. Hensley, N. E. Babady, Josephine R. Giles, Madison E. Weirick, Justin Kim, K. Naik, Sawsan R. Boutemine, Laura A. Vella, Sharon Adamski, Jennifer E. Wu, Florence Porterfield, Alexander C. Huang, Ryan Massa, S. Tollett, Alfred L. Garfall, Sigrid Gouma, Emily M. Kugler, Heather M. Giannini, Tiffanie K. Jones, Oluwatosin Oniyide, John P. Reilly, Erin Bange, R.S. Agyekum, E. P. Wileyto, Olutosin Owoyemi, Robert H. Vonderheide, Cathy Zheng
Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer patients hospitalized for COVID-19 at the University of Pennsylvania Health S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::343bff30d7eb38b79dc0033a8c420d20
https://doi.org/10.21203/rs.3.rs-162289/v1
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6
A Screen for Cryptosporidium Rhoptry Proteins Identifies ROP1 as an Effector Targeting the Host Cytoskeletal Modulator LMO7
Autor: Emily M. Kugler, Boris Striepen, Jung-Bum Shin, Janis K. Burkhardt, Nathan H. Roy, Amandine Guérin, Laurence Berry-Sterkers
Publikováno v: SSRN Electronic Journal.
The parasite Cryptosporidium invades and replicates in intestinal epithelial cells and is a leading cause of diarrheal disease and early childhood mortality. The molecular mechanisms that underlie infection and pathogenesis are largely unknown. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07996610c37bc74bcf58c582d9ab04ad
https://doi.org/10.2139/ssrn.3819810
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7
The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6
Autor: Jodi A. Gullicksrud, Aaron M. Ring, Boris Striepen, Igor E. Brodsky, Emily M. Kugler, Christopher A. Hunter, Ting Zhou, Julie B. Engiles, Jorge Henao-Mejia, Briana I. McLeod, Adam Sateriale
Publikováno v: Proceedings of the National Academy of Sciences. 118
The apicomplexan parasite Cryptosporidium infects the intestinal epithelium. While infection is widespread around the world, children in resource-poor settings suffer a disproportionate disease burden. Cryptosporidiosis is a leading cause of diarrhea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b20ce17136f21fdeecfb83e0d51f02f6
https://doi.org/10.1073/pnas.2007807118
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8
Protective Immunity in a Genetically Tractable Natural Mouse Model of Cryptosporidiosis
Autor: Carrie F. Brooks, Julie B. Engiles, Boris Striepen, Christopher A. Hunter, Jan Šlapeta, Gillian T. Herbert, Emily M. Kugler, Jodi A. Gullicksrud, Jessica C. Kissinger, Adam Sateriale, Rodrigo P. Baptista
Publikováno v: SSRN Electronic Journal.
Cryptosporidium is a leading cause of diarrheal disease and an important contributor to early childhood mortality, malnutrition, and growth faltering. Older children in high endemicity regions appear resistant to infection, while previously unexposed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58d321e6e1ca1729865355ced1bd3d9c
https://doi.org/10.2139/ssrn.3362259
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9
A Genetically Tractable, Natural Mouse Model of Cryptosporidiosis Offers Insights into Host Protective Immunity
Autor: Gillian T. Herbert, Emily M. Kugler, Rodrigo P. Baptista, Adam Sateriale, Christopher A. Hunter, Jodi A. Gullicksrud, Boris Striepen, Carrie F. Brooks, Jessica C. Kissinger, Jan Šlapeta, Julie B. Engiles
Publikováno v: Cell Host & Microbe. 26:135-146.e5
Summary Cryptosporidium is a leading cause of diarrheal disease and an important contributor to early childhood mortality, malnutrition, and growth faltering. Older children in high endemicity regions appear resistant to infection, while previously u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a65ec582e228eab354c740472398a4a
https://doi.org/10.1016/j.chom.2019.05.006
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