Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Emily M. J. Fennell"'
Autor:
Emily M. J. Fennell, Lucas J. Aponte-Collazo, Wimal Pathmasiri, Blake R. Rushing, Natalie K. Barker, Megan C. Partridge, Yuan-Yuan Li, Cody A. White, Yoshimi E. Greer, Laura E. Herring, Stanley Lipkowitz, Susan C. J. Sumner, Edwin J. Iwanowicz, Lee M. Graves
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been
Externí odkaz:
https://doaj.org/article/8ff4ea8f38e048409bf256e5266ae0c6
Autor:
Emily M. J. Fennell, Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer, Paul R. Graves, Andrew A. Iwanowicz, Hani Ashamalla, Ekhson Holmuhamedov, Henk Lang, Donald S. Karanewsky, Channing J. Der, Walid A. Houry, Stanley Lipkowitz, Edwin J. Iwanowicz, Lee M. Graves
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the relat
Externí odkaz:
https://doaj.org/article/d148e9686840428483903862c1681076
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1598 (2023)
Transcription of the mitochondrial genome is essential for the maintenance of oxidative phosphorylation (OXPHOS) and other functions directly related to this unique genome. Considerable evidence suggests that mitochondrial transcription is dysregulat
Externí odkaz:
https://doaj.org/article/3488b9a8de54493b8bae98674e413075
Autor:
Lucas J. Aponte-Collazo, Emily M. J. Fennell, Michael P. East, Thomas S. K. Gilbert, Paul R. Graves, Hani Ashamalla, Edwin J. Iwanowicz, Yoshimi Endo Greer, Stanley Lipkowitz, Lee M. Graves
Imipridones are a novel class of anticancer drugs with promising antiproliferative effects in several cancer cell types, including breast cancer. Recent studies identified the mitochondrial ATP-dependent caseinolytic peptidase P (ClpP) as the target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd238406dd7c3c8c2c59ead2d7c8c437
https://doi.org/10.1101/2022.07.11.499620
https://doi.org/10.1101/2022.07.11.499620
Autor:
Paul R. Graves, Lucas J. Aponte-Collazo, Emily M. J. Fennell, Adam C. Graves, Andrew E. Hale, Nedyalka Dicheva, Laura E. Herring, Thomas S. K. Gilbert, Michael P. East, Ian M. McDonald, Matthew R. Lockett, Hani Ashamalla, Nathaniel J. Moorman, Donald S. Karanewsky, Edwin J. Iwanowicz, Ekhson Holmuhamedov, Lee M. Graves
Publikováno v:
ACS Chemical Biology. 17:2377-2378
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15ec58c9576adc0b639bb2c10daa3347
https://doi.org/10.1021/acschembio.2c00545
https://doi.org/10.1021/acschembio.2c00545