Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Emily M. Dieter"'
Autor:
Zachary E. Potter, Linglan Fang, Emily M. Dieter, Dustin J. Maly, Chloe K. Lombard, Sujata Chakraborty
Publikováno v:
J Am Chem Soc
Small molecule inhibitors often only block a subset of the cellular functions of their protein targets. In many cases, how inhibiting only a portion of a multi-functional protein’s functions affects the state of the cell is not well understood. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9219d2fa80c8d0a6cf49276bb646267
https://doi.org/10.1021/jacs.9b02963
https://doi.org/10.1021/jacs.9b02963
Autor:
Glenna Wink Foight, Daniel Cunningham-Bryant, John C. Rose, Dana E. Loutey, Dustin J. Maly, Emily M. Dieter
Publikováno v:
Journal of the American Chemical Society. 141:3352-3355
Chemical methods that allow the spatial proximity of proteins to be temporally modulated are powerful tools for studying biology and engineering synthetic cellular behaviors. Here, we describe a new chemically-controlled method for rapidly disrupting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799775c12c4b54d21a5910fec1cf4c84
https://doi.org/10.1021/jacs.8b12382
https://doi.org/10.1021/jacs.8b12382
Autor:
Emily M, Dieter, Dustin J, Maly
Publikováno v:
Methods in enzymology. 633
RAS GTPases are involved in a number of dynamic signaling processes and have been a major focus of research due to the prevalence of activating RAS mutations in cancer. However, despite decades of research, some fundamental aspects of RAS biology are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16d410ddd0347d4e4d64cd277ab83374
https://pubmed.ncbi.nlm.nih.gov/32046841
https://pubmed.ncbi.nlm.nih.gov/32046841
Autor:
Dustin J. Maly, Emily M. Dieter
RAS GTPases are involved in a number of dynamic signaling processes and have been a major focus of research due to the prevalence of activating RAS mutations in cancer. However, despite decades of research, some fundamental aspects of RAS biology are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efd00c8fb3cfcb9a13998e01bae17a9d
https://doi.org/10.1016/bs.mie.2019.10.033
https://doi.org/10.1016/bs.mie.2019.10.033
Publikováno v:
Small GTPases
RAS signaling pathways govern diverse cellular processes, are dynamic, and exhibit marked plasticity. Yet, these features also present a considerable obstacle to their study. Here, we report the use of a recently described RAS rheostat, Chemically In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc94c5f63529a5bb037a97806a9d93d5
https://doi.org/10.1080/21541248.2018.1446697
https://doi.org/10.1080/21541248.2018.1446697
Autor:
Jason J. Stephany, Emily M. Dieter, Ethan Ahler, Ames C. Register, Martin Golkowski, Dustin J. Maly, Katherine A. Sitko, Rama Subba Rao Vidadala, Ethan A. Merritt, Linglan Fang, Bridget M. Trevillian, Douglas M. Fowler, Alan F. Rubin, Sujata Chakraborty, Hannah Gelman
Publikováno v:
Molecular Cell. 74:393-408.e20
Multiple layers of regulation modulate the activity and localization of protein kinases. However, many details of kinase regulation remain incompletely understood. Here, we apply saturation mutagenesis and a chemical genetic method for allosterically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84922f1816831bdb261e347f535f3fc1
https://doi.org/10.1016/j.molcel.2019.02.003
https://doi.org/10.1016/j.molcel.2019.02.003
Publikováno v:
Bioanalysis. 4:2525-2541
The identification and quantification of important biomarkers is a critical first step in the elucidation of biological systems. Biomarkers take many forms as cellular responses to stimuli and can be manifested during transcription, translation, and/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5893cf32e095118e9ee49c2dc1450b
https://doi.org/10.4155/bio.12.208
https://doi.org/10.4155/bio.12.208