CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand

Autor: Tony R Merriman, Hong Cheng, Nicola L Hawley, Ranjan Deka, Stephen T McGarvey, Emily M Russell, Jenna C Carlson, Mohanraj Krishnan, Guangyun Sun, Take Naseri, Muagututi‘a Sefuiva Reupena, Satupa‘itea Viali, John Tuitele, Tanya J Major, Iva Miljkovic, Daniel E Weeks, Ryan L Minster

Publikováno v: BMJ Open Diabetes Research & Care, Vol 10, Iss 1 (2022)

Externí odkaz: https://doaj.org/article/457117ff29094d4cb85ca10daaa71a6d

Implementation of Universal Pan-Cancer Germline Genetic Testing in an Arab Population: The Jordanian Exploratory Cancer Genetics Study

Autor: Hikmat Abdel-Razeq, Baha' Sharaf, Hira Bani Hani, Ramiz Abu Hijlih, Mais Alkyam, Khansa Al-Azzam, Shatha Elemian, Abdelghani Tbakhi, Areej Al-Atary, Rachel E. Ellsworth, Emily M. Russell, Edward D. Esplin, Malek Horani, Zeidan Zeidan, Abdulla Alzibdeh, Brandie Heald, Sarah M. Nielsen, Robert L. Nussbaum

Publikováno v: JCO Global Oncology, Vol , Iss 10 (2024)

PURPOSEGermline genetic testing (GGT) significantly affects cancer care. While universal testing has been studied in Western societies, less is known about adoption elsewhere.MATERIALS AND METHODSIn this study, 3,319 unselected, pan-cancer Jordanian

Externí odkaz: https://doaj.org/article/7d5166b37872449cb505823fc6b1095c

A Polynesian-specific missense CETP variant alters the lipid profile

Autor: Jaye Moors, Mohanraj Krishnan, Nick Sumpter, Riku Takei, Matt Bixley, Murray Cadzow, Tanya J. Major, Amanda Phipps-Green, Ruth Topless, Marilyn Merriman, Malcolm Rutledge, Ben Morgan, Jenna C. Carlson, Jerry Z. Zhang, Emily M. Russell, Guangyun Sun, Hong Cheng, Daniel E. Weeks, Take Naseri, Muagututi’a Sefuiva Reupena, Satupa’itea Viali, John Tuitele, Nicola L. Hawley, Ranjan Deka, Stephen T. McGarvey, Janak de Zoysa, Rinki Murphy, Nicola Dalbeth, Lisa Stamp, Mele Taumoepeau, Frances King, Phillip Wilcox, Nuku Rapana, Sally McCormick, Ryan L. Minster, Tony R. Merriman, Megan Leask

Publikováno v: HGG Advances, Vol 4, Iss 3, Pp 100204- (2023)

Summary: Identifying population-specific genetic variants associated with disease and disease-predisposing traits is important to provide insights into the genetic determinants of health and disease between populations, as well as furthering genomic

Externí odkaz: https://doaj.org/article/7af5bffb2a1a41c9a4a3264dd197c255

Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations

Autor: Mohanraj Krishnan, Amanda Phipps-Green, Emily M. Russell, Tanya J. Major, Murray Cadzow, Lisa K. Stamp, Nicola Dalbeth, Jennie Harré Hindmarsh, Muhammad Qasim, Huti Watson, Shuwei Liu, Jenna C. Carlson, Ryan L. Minster, Nicola L. Hawley, Take Naseri, Muagututi’a Sefuiva Reupena, Ranjan Deka, Stephen T. McGarvey, Tony R. Merriman, Rinki Murphy, Daniel E. Weeks

Publikováno v: Journal of Human Genetics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f59b5ee11924c64677901a459a0823b
https://doi.org/10.1038/s10038-023-01141-5

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program

Autor: Daniel DiCorpo, Sheila M. Gaynor, Emily M. Russell, Kenneth E. Westerman, Laura M. Raffield, Timothy D. Majarian, Peitao Wu, Chloé Sarnowski, Heather M. Highland, Anne Jackson, Natalie R. Hasbani, Paul S. de Vries, Jennifer A. Brody, Bertha Hidalgo, Xiuqing Guo, James A. Perry, Jeffrey R. O’Connell, Samantha Lent, May E. Montasser, Brian E. Cade, Deepti Jain, Heming Wang, Ricardo D’Oliveira Albanus, Arushi Varshney, Lisa R. Yanek, Leslie Lange, Nicholette D. Palmer, Marcio Almeida, Juan M. Peralta, Stella Aslibekyan, Abigail S. Baldridge, Alain G. Bertoni, Lawrence F. Bielak, Chung-Shiuan Chen, Yii-Der Ida Chen, Won Jung Choi, Mark O. Goodarzi, James S. Floyd, Marguerite R. Irvin, Rita R. Kalyani, Tanika N. Kelly, Seonwook Lee, Ching-Ti Liu, Douglas Loesch, JoAnn E. Manson, Ryan L. Minster, Take Naseri, James S. Pankow, Laura J. Rasmussen-Torvik, Alexander P. Reiner, Muagututi’a Sefuiva Reupena, Elizabeth Selvin, Jennifer A. Smith, Daniel E. Weeks, Huichun Xu, Jie Yao, Wei Zhao, Stephen Parker, Alvaro Alonso, Donna K. Arnett, John Blangero, Eric Boerwinkle, Adolfo Correa, L. Adrienne Cupples, Joanne E. Curran, Ravindranath Duggirala, Jiang He, Susan R. Heckbert, Sharon L. R. Kardia, Ryan W. Kim, Charles Kooperberg, Simin Liu, Rasika A. Mathias, Stephen T. McGarvey, Braxton D. Mitchell, Alanna C. Morrison, Patricia A. Peyser, Bruce M. Psaty, Susan Redline, Alan R. Shuldiner, Kent D. Taylor, Ramachandran S. Vasan, Karine A. Viaud-Martinez, Jose C. Florez, James G. Wilson, Robert Sladek, Stephen S. Rich, Jerome I. Rotter, Xihong Lin, Josée Dupuis, James B. Meigs, Jennifer Wessel, Alisa K. Manning

Publikováno v: Communications biology, vol 5, iss 1

The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses from fiftee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acafe562d1ada735d551df3e43ee1eca
https://doi.org/10.1038/s42003-022-03702-4