Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Emily M, Pitzer"'
Autor:
Michael T. Williams, Chiho Sugimoto, Samantha L. Regan, Emily M. Pitzer, Adam L. Fritz, Anthony E. Mascia, Mathieu Sertorio, Ralph E. Vatner, John P. Perentesis, Charles V. Vorhees
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Abstract Proton radiotherapy causes less off-target effects than X-rays but is not without effect. To reduce adverse effects of proton radiotherapy, a model of cognitive deficits from conventional proton exposure is needed. We developed a model empha
Externí odkaz:
https://doaj.org/article/5d32edd717014b9596a855396e69d6d1
Autor:
Emily M. Pitzer, Chiho Sugimoto, Samantha L. Regan, Gary A. Gudelsky, Michael T. Williams, Charles V. Vorhees
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100093- (2022)
Pyrethroid pesticides are widely used and can cause long-term effects after early exposure. Epidemiological and animal studies reveal associations between pyrethroid exposure and altered cognition following prenatal and/or neonatal exposure. However,
Externí odkaz:
https://doaj.org/article/082ff1bf5a4f4e23b7c453dc6e546d6b
Autor:
Michael T Williams, Chiho Sugimoto, Samantha L Regan, Emily M Pitzer, Adam L Fritz, Mathieu Sertorio, Anthony E Mascia, Ralph E Vatner, John P Perentesis, Charles V Vorhees
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274007 (2022)
Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive decline compared with conventional radiation dose rates (~1 Gy/s), but further preclinical dat
Externí odkaz:
https://doaj.org/article/8cca211bfd4841748d9af0addd081e91
Autor:
Samantha L. Regan, Emily M. Pitzer, Jillian R. Hufgard, Chiho Sugimoto, Michael T. Williams, Charles V. Vorhees
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105456- (2021)
Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in
Externí odkaz:
https://doaj.org/article/02d801f1a8994218b16fd0930b543a3e
Autor:
Samantha L. Regan, Jillian R. Hufgard, Emily M. Pitzer, Chiho Sugimoto, Yueh-Chiang Hu, Michael T. Williams, Charles V. Vorhees
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104494- (2019)
Attention deficit hyperactivity disorder is a pervasive developmental disorder characterized by inattention, impulsivity, and hyperactivity and is 75–90% heritable. Latrophilin-3 (LPHN3; or ADGRL(3)) is associated with a subtype of ADHD, but how it
Externí odkaz:
https://doaj.org/article/c41c9e4579ce4005be30cbffbec39db8
Autor:
Charles V. Vorhees, Emily M. Pitzer, Gary A. Gudelsky, Chiho Sugimoto, Michael T. Williams, Courtney L Huff Adams
Publikováno v:
Toxicol Sci
Pyrethroids are synthetic insecticides that act acutely on voltage gated sodium channels to prolong channel opening and depolarization. Epidemiological studies find that exposure to pyrethroids are associated with neurological and developmental abnor
Autor:
Charles V. Vorhees, Sheryl E. Koch, Jenna L.N. Sprowles, Xiang Zhang, Qin Wang, Michael T. Williams, Alvaro Puga, Jacek Biesiada, Min Jiang, Emily M. Pitzer, Jillian R. Hufgard, Jack Rubinstein
Publikováno v:
Journal of Applied Toxicology. 39:603-621
Polychlorinated biphenyls (PCBs) are toxic environmental pollutants. Humans are exposed to PCB mixtures via contaminated food or water. PCB exposure causes adverse effects in adults and after exposure in utero. PCB toxicity depends on the congener mi
Publikováno v:
Neurotoxicol Teratol
Deltamethrin (DLM) is a Type II pyrethroid pesticide widely used in agriculture, homes, public spaces, and medicine. Epidemiological studies report that increased pyrethroid exposure during development is associated with neurobehavioral disorders. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef0a3ae5591c02d44f64e84da730b52
https://europepmc.org/articles/PMC8440325/
https://europepmc.org/articles/PMC8440325/
Autor:
Emily M. Pitzer, Charles V. Vorhees, Chiho Sugimoto, Ralph E. Vatner, John P. Perentesis, Samantha L. Regan, Adam L. Fritz, Mathieu Sertorio, Anthony Mascia, Michael T. Williams
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Proton radiotherapy causes less off-target effects than X-rays but is not without effect. To reduce adverse effects of proton radiotherapy, a model of cognitive deficits from conventional proton exposure is needed. We developed a model emphasizing mu
Autor:
Chiho Sugimoto, Charles V. Vorhees, Michael T. Williams, Jillian R. Hufgard, Samantha L. Regan, Emily M. Pitzer
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 158, Iss, Pp 105456-(2021)
Neurobiology of Disease, Vol 158, Iss, Pp 105456-(2021)
Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of LPHN3 are associated with ADHD. Null mutations of Lphn3 in