Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Emily M, Jutkiewicz"'
Autor:
Lauren G. Rysztak, Emily M. Jutkiewicz
Publikováno v:
Frontiers in Systems Neuroscience, Vol 16 (2022)
Enkephalin, an endogenous opioid peptide, is highly expressed in the reward pathway and may modulate neurotransmission to regulate reward-related behaviors, such as drug-taking and drug-seeking behaviors. Drugs of abuse also directly increase enkepha
Externí odkaz:
https://doaj.org/article/54983d41ab1745d7be4ec181b7ca4384
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 398 (2022)
There is substantial evidence that cholinergic system function impairment plays a significant role in many central nervous system (CNS) disorders. During the past three decades, muscarinic receptors (mAChRs) have been implicated in various pathologie
Externí odkaz:
https://doaj.org/article/58219d084dc5447082d6c51a0191f535
Publikováno v:
Exp Clin Psychopharmacol
Protein kinase C (PKC) is important for the mechanism of action of amphetamine (AMPH). Inhibiting PKC blocks AMPH-stimulated increases in extracellular dopamine levels and AMPH-stimulated locomotor activity. This study examined the effects of PKC inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723e0b58189d4dce82b1efb7d04c200f
https://doi.org/10.1037/pha0000425
https://doi.org/10.1037/pha0000425
Autor:
Keith M. Olson, Todd M. Hillhouse, Gwendolyn E. Burgess, Joshua L. West, James E. Hallahan, Isaac J. Dripps, Allison G. Ladetto, Kenner C. Rice, Emily M. Jutkiewicz, John R. Traynor
Publikováno v:
J Pharmacol Exp Ther
Major depressive disorder is a highly common disorder, with a lifetime prevalence in the United States of approximately 21%. Traditional antidepressant treatments are limited by a delayed onset of action and minimal efficacy in some patients. Ketamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5714b94c2515eb3171dbf241ed746d
https://pubmed.ncbi.nlm.nih.gov/36456196
https://pubmed.ncbi.nlm.nih.gov/36456196
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0c9b20d06344cf5cecdfd676f11561a
https://doi.org/10.1096/fasebj.2022.36.s1.r5082
https://doi.org/10.1096/fasebj.2022.36.s1.r5082
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18527e01eaccc667d46fe8938cca9bf4
https://doi.org/10.1096/fasebj.2022.36.s1.r5514
https://doi.org/10.1096/fasebj.2022.36.s1.r5514
Publikováno v:
Behav Pharmacol
This study aimed to use central and peripheral assays to compare the effects of the muscarinic antagonist scopolamine with those of a novel muscarinic antagonist, L-687,306 [(3R,4R)-3-(3-cyclopropyl-1,2,4,oxadiazol[5-yl]-1-azabicyclo[2.2.1]heptane. G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4559500cf769adda87c08ccc3eac5c82
https://doi.org/10.1097/fbp.0000000000000537
https://doi.org/10.1097/fbp.0000000000000537
Autor:
Kathryn E. Livingston, Emily M. Jutkiewicz, Alexander Disney, Stephen M. Husbands, Ruizhuo Chen, John R. Traynor, Kenner C. Rice, Amanda M. Shafer, Isaac J. Dripps
Publikováno v:
J Pharmacol Exp Ther
δ-Opioid receptor (δ-receptor) agonists produce antihyperalgesia, antidepressant-like effects, and convulsions in animals. However, the role of agonist efficacy in generating different δ-receptor–mediated behaviors has not been thoroughly invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc1cd61690216c19b61022c3d6328b7
https://doi.org/10.1124/jpet.119.262717
https://doi.org/10.1124/jpet.119.262717
Publikováno v:
Molecular pharmacology. 102(6)
Pain management is an important problem worldwide. The current frontline approach for pain management is the use of opioid analgesics. The primary analgesic target of opioids is theiμ/i-opioid receptor (MOR). Deletion of phospholipase Ciβ/i3 (PLCi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d23ff49410410688868c7ef8665931b
https://pubmed.ncbi.nlm.nih.gov/36116788
https://pubmed.ncbi.nlm.nih.gov/36116788
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 2, Pp 121-124 (2011)
Abstract.: Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (−)-Nicotine bitar
Externí odkaz:
https://doaj.org/article/47d0bd6529cd4caa9be7962e0d23a5b6