Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Emily Luk"'
Autor:
A. K. Ganguly, Guodong Chen, Birendra N. Pramanik, Ibrahim Daaro, Emily Luk, Peter L. Bartner, Anil K. Saksena, Viyyoor M. Girijavallabhan
Publikováno v:
ARKIVOC, Vol 2003, Iss 3, Pp 31-44 (2003)
Externí odkaz:
https://doaj.org/article/aec76887aeb24fa4a3573d36d27c775c
Autor:
Shiuhang Yip, Emily Luk, Anwar Murtaza, Yong Zhang, Michael A. Poss, Louis J. Lombardo, Nimmi Raghavan, Zheng Yang, James Kempson, Audris Huang, David R. Tortolani, Jesse Swanson, Xiaoping Hou, Joseph Pawluczyk, James Smalley, Honghe Wan, Karen E. Parrish, Robert M. Borzilleri, Ashok V. Purandare, Karen Augustine-Rauch, Andrew F. Donnell
Publikováno v:
Journal of Medicinal Chemistry. 64:15787-15798
Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models. However, on-target adverse cardiovascular effects have limited the clinical use of TGFβ rec
Autor:
Emily Luk, Karen E. Parrish, Yue-Zhong Shu, Anwar Murtaza, Yongnian Sun, Jinwen Huang, Robert M. Borzilleri, Paul Stetsko, Mary Ellen Cvijic, Jonathan G. Pabalan, Lihong Cheng, Zheng Yang, Jesse Swanson, James R. Burke, Tatyana Zvyaga, James Smalley, Karen A. Augustine
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:137-149
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that has a wide array of biological effects. For decades, tumor biology implicated TGF-β as an attractive therapeutic target due to its immunosuppressive effects. Toward this end, mu
Autor:
Mary Jane Cullen, Qian Xiang, Jeffrey A. Robl, Philip M. Sher, Brian J. Murphy, Keith J. Miller, Timothy M. Harper, Andrew Alt, Emily Luk, Sarah E. Malmstrom, Dean A. Wacker, Ginger Wu, Kimberly A. Foster, John M. Fevig, Joseph Carpenter, Robert L. Bertekap, Mary F. Grubb, Ying Wang, Karen A. Rossi, Gang Wu, Christian L. Morales, Jianxin Feng, Xiang Yang Ye, Anthony V. Azzara, Matthias Broekema
Publikováno v:
Journal of Medicinal Chemistry. 60:6166-6190
Agonism of the 5-HT2C receptor represents one of the most well-studied and clinically proven mechanisms for pharmacological weight reduction. Selectivity over the closely related 5-HT2A and 5-HT2B receptors is critical as their activation has been sh
Autor:
Yong Zhang, Parrish, Karen E., Tortolani, David R., Poss, Michael A., Audris Huang, Honghe Wan, Purandare, Ashok V., Donnell, Andrew F., Kempson, James, Xiaoping Hou, Pawluczyk, Joseph, Shiuhang Yip, Emily Luk, Raghavan, Nimmi, Swanson, Jesse, Smalley, James, Murtaza, Anwar, Zheng Yang, Augustine-Rauch, Karen, Lombardo, Louis J.
Publikováno v:
Journal of Medicinal Chemistry; 11/11/2021, Vol. 64 Issue 21, p15787-15798, 12p
Autor:
Joseph, Carpenter, Ying, Wang, Gang, Wu, Jianxin, Feng, Xiang-Yang, Ye, Christian L, Morales, Matthias, Broekema, Karen A, Rossi, Keith J, Miller, Brian J, Murphy, Ginger, Wu, Sarah E, Malmstrom, Anthony V, Azzara, Philip M, Sher, John M, Fevig, Andrew, Alt, Robert L, Bertekap, Mary Jane, Cullen, Timothy M, Harper, Kimberly, Foster, Emily, Luk, Qian, Xiang, Mary F, Grubb, Jeffrey A, Robl, Dean A, Wacker
Publikováno v:
Journal of medicinal chemistry. 60(14)
Agonism of the 5-HT
Autor:
Gerry Everlof, Chen-Pin Hung, Bradley A. Zinker, Ginger Wu, Steven C. Griffen, Stephanie Boehm, Hong Cai, Larisa Sereda, Li Xin, Matthias Broekema, Linda LaMarre, Sarah E. Malmstrom, Randolph P. Ponticiello, Cuixia Chu, Anjaneya Chimalakonda, Jeffrey A. Robl, Chiuwa Emily Luk, Michelle Lee, Steven O’Connor, Rachel Zebo, Keith J. Miller, Ying Wang, Richard L. Wong, John Krupinski, Zhenqiu Hong, Lisa Zhang, Jacob Zalaznick, Songping Han, Chunyu K. Wu, Yi-Xin Li, Karen A. Rossi, Dean A. Wacker
Publikováno v:
Journal of Medicinal Chemistry. 57:7499-7508
G-protein-coupled receptor 119 (GPR119) is expressed predominantly in pancreatic β-cells and in enteroendocrine cells in the gastrointestinal tract. GPR119 agonists have been shown to stimulate glucose-dependent insulin release by direct action in t