Sexual and gender identity and note-leaving among adult suicide decedents in the USA

Autor: Holly P. O'Rourke, Chanler D. Hilley, Emily Lowell, Connor M. Sheehan

Publikováno v: BJPsych Open, Vol 9 (2023)

Background Suicide is one of the leading causes of preventable death in the USA, representing a critical public health threat. Suicide risks differ for different populations. In particular, the sexual and gender minority (SGM) population remains at i

Externí odkaz: https://doaj.org/article/d05b0629681548b5aec269caee49d870

Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype.

Autor: Anja Forche, Norma V Solis, Marc Swidergall, Robert Thomas, Alison Guyer, Annette Beach, Gareth A Cromie, Giang T Le, Emily Lowell, Norman Pavelka, Judith Berman, Aimeé M Dudley, Anna Selmecki, Scott G Filler

Publikováno v: PLoS Genetics, Vol 15, Iss 5, p e1008137 (2019)

When the fungus Candida albicans proliferates in the oropharyngeal cavity during experimental oropharyngeal candidiasis (OPC), it undergoes large-scale genome changes at a much higher frequency than when it grows in vitro. Previously, we identified a

Externí odkaz: https://doaj.org/article/404d9c387d5f45d796ff618e3ff1ebc0

Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice

Autor: Michael V. Wiles, Gregory J. Christianson, Wenning Qin, Benjamin E. Low, Emily Lowell

Publikováno v: mAbs
article-version (VoR) Version of Record

A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b257c8c3f4115ce28b3be6197304d876
https://doi.org/10.1080/19420862.2020.1829334

Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype

Autor: Anna Selmecki, Norman Pavelka, Marc Swidergall, Annette Beach, Anja Forche, Giang T. Le, Judith Berman, Scott G. Filler, Aimée M. Dudley, Gareth A. Cromie, Norma V. Solis, Alison Guyer, Robert Thomas, Emily Lowell

Publikováno v: PLoS Genetics
PLoS genetics, vol 15, iss 5
Forche, Anja; Solis, Norma V; Swidergall, Marc; Thomas, Robert; Guyer, Alison; Beach, Annette; et al.(2019). Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype.. PLoS genetics, 15(5), e1008137. doi: 10.1371/journal.pgen.1008137. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3qh9v1t0
PLoS Genetics, Vol 15, Iss 5, p e1008137 (2019)

When the fungus Candida albicans proliferates in the oropharyngeal cavity during experimental oropharyngeal candidiasis (OPC), it undergoes large-scale genome changes at a much higher frequency than when it grows in vitro. Previously, we identified a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54eeafef3fbc60a81d46a3cf9d822d1
https://pubmed.ncbi.nlm.nih.gov/31091232

Abstract 4905: Utility of human FcRn transgenic mice for preclinical screening of immunotherapeutics

Autor: Gregory J. Christianson, Emily Lowell, Cat Lutz

Publikováno v: Cancer Research. 78:4905-4905

Preclinical assessment is required for the growing number of immunotherapeutics in development. Clinically relevant pharmacokinetic analysis can be achieved by using transgenic mice that uniquely express the human Fc receptor neonatal (hFcRn). To dem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4c3d298b7e134bf1632630b230332e4
https://doi.org/10.1158/1538-7445.am2018-4905