Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Emily Lorenzen"'
Autor:
Shahar Barbash, Torbjörn Persson, Emily Lorenzen, Manija A. Kazmi, Thomas Huber, Thomas P. Sakmar
Publikováno v:
iScience, Vol 11, Iss , Pp 366-374 (2019)
Summary: A recent phylogenetic analysis showed global co-evolution of G protein-coupled receptors (GPCRs) and receptor-activity-modifying proteins (RAMPs) suggesting global interactions between these two protein families. Experimental validation of t
Externí odkaz:
https://doaj.org/article/d4a1054777b746d08de3e6f2299b7cd2
Publikováno v:
Pharmacological Reviews. 75:1-34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42e0ffa1234ef610dd3f15eddc013ad
https://doi.org/10.1124/pharmrev.120.000180
https://doi.org/10.1124/pharmrev.120.000180
Autor:
Ilana B. Kotliar, Emilie Ceraudo, Kevin Kemelmakher-Liben, Deena A. Oren, Emily Lorenzen, Tea Dodig-Crnković, Mizuho Horioka-Duplix, Thomas Huber, Jochen M. Schwenk, Thomas P. Sakmar
Cholestatic itch is a severe and debilitating symptom in liver diseases with limited treatment options. The class A G protein-coupled receptor (GPCR) Mas-related GPCR subtype X4 (MRGPRX4) has been identified as a receptor for bile acids, which are po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea545bcb14d10447ee8ac84af1e9e567
https://doi.org/10.1101/2022.12.06.519316
https://doi.org/10.1101/2022.12.06.519316
Autor:
Ilana B. Kotliar, Emilie Ceraudo, Kevin Kemelmakher-Liben, Deena A. Oren, Emily Lorenzen, Tea Dodig-Crnković, Mizuho Horioka-Duplix, Thomas Huber, Jochen M. Schwenk, Thomas P. Sakmar
Publikováno v:
Journal of Biological Chemistry. 299:104664
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4898d023310b7e03c05fff9a57cd667a
https://doi.org/10.1016/j.jbc.2023.104664
https://doi.org/10.1016/j.jbc.2023.104664
Publikováno v:
Cellular and Molecular Neurobiology. 41:1085-1101
Many G protein-coupled receptors (GPCRs) signal through more than one subtype of heterotrimeric G proteins. For example, the C–C chemokine receptor type 5 (CCR5), which serves as a co-receptor to facilitate cellular entry of human immunodeficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59f68312ee5f993b83f499e6c8a7f231
https://doi.org/10.1007/s10571-020-01002-1
https://doi.org/10.1007/s10571-020-01002-1
Publikováno v:
Cellular and Molecular Neurobiology
Many G protein-coupled receptors (GPCRs) signal through more than one subtype of heterotrimeric G proteins. For example, the C–C chemokine receptor type 5 (CCR5), which serves as a co-receptor to facilitate cellular entry of human immunodeficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f6a5c191b7dc5969b92f7ff964020ac
https://pubmed.ncbi.nlm.nih.gov/33216235
https://pubmed.ncbi.nlm.nih.gov/33216235
Autor:
Thomas P. Sakmar, Thomas Huber, Shahar Barbash, Torbjörn Persson, Manija A. Kazmi, Emily Lorenzen
Publikováno v:
iScience
iScience, Vol 11, Iss, Pp 366-374 (2019)
iScience, Vol 11, Iss, Pp 366-374 (2019)
Summary A recent phylogenetic analysis showed global co-evolution of G protein-coupled receptors (GPCRs) and receptor-activity-modifying proteins (RAMPs) suggesting global interactions between these two protein families. Experimental validation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdc73de23749f77939e227675d09dad
https://doi.org/10.1016/j.isci.2018.12.024
https://doi.org/10.1016/j.isci.2018.12.024
Autor:
Emily Lorenzen, Thomas P. Sakmar
Publikováno v:
Cell. 176:409-411
The cannabinoid receptor CB2 is predominately expressed in the immune system and selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in inflammatory, fibrotic and neurodegenerative diseases. Here we report the crys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ca26a1b064ffeabe4d4afd610a5e29
https://doi.org/10.1016/j.cell.2019.01.012
https://doi.org/10.1016/j.cell.2019.01.012
Autor:
Emily Lorenzen, Tea Dodig-Crnković, Ilana B. Kotliar, Jochen M. Schwenk, Elisa Pin, Emilie Ceraudo, Roger D. Vaughan, Thomas P. Sakmar, Thomas Huber, Mathias Uhlén
Publikováno v:
Science Advances
We used a multiplexed suspension bead array immunoassay to map GPCR-receptor activity–modifying protein (RAMP) complexes.
Receptor activity–modifying proteins (RAMPs) have been shown to modulate the functions of several G protein–coupled r
Receptor activity–modifying proteins (RAMPs) have been shown to modulate the functions of several G protein–coupled r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56db96055e64ea9bba26a9439565d1c2
http://europepmc.org/articles/PMC6750928
http://europepmc.org/articles/PMC6750928
Autor:
He Tian, Jennifer C. Peeler, Manija A. Kazmi, Thomas Huber, Mizuho Horioka, Alexandre Fürstenberg, Oliver Hartley, Thomas P. Sakmar, Emily Lorenzen, Yamina A. Berchiche, Carlos A. Rico, Hubert François Gaertner
The chemokine receptor CCR5 is a drug target to prevent transmission of HIV/AIDS. We studied four analogs of the native chemokine RANTES (CCL5) that have anti-HIV potencies of around 25 pM, which is more than four orders-of-magnitude higher than that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60272af1e30def26b3c4dbced0d36b5f
https://doi.org/10.1101/575795
https://doi.org/10.1101/575795