Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Emily L. Whitson"'
Autor:
Lauren R.H. Krumpe, Alena Naumova, Adel Chergui, Christophe Marchand, Tawnya C. McKee, Emily L. Whitson, Barry R. O'Keefe, Yves Pommier, Curtis J. Henrich, Ekaterina I. Goncharova, Edmund Price, Jason R. Evans, Alun Bermingham
Publikováno v:
SLAS Discov
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme crucial for cleavage of the covalent topoisomerase 1-DNA complex, an intermediate in DNA repair. TDP1 plays a role in reversing inhibition of topoisomerase I by camptothecins, a series of potent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9eda94ef2d86771d97178fb88a1eb84
https://pubmed.ncbi.nlm.nih.gov/28697309
https://pubmed.ncbi.nlm.nih.gov/28697309
Autor:
James B. McMahon, Curtis J. Henrich, Cheryl L. Thomas, Christian Griesinger, Tawnya C. McKee, Han Sun, Emily L. Whitson, Thomas J. Sayers
Publikováno v:
Journal of Natural Products
Barleria alluaudii and Diospyros maritima were both investigated as part of an ongoing search for synergistic TRAIL (tumor necrosis factor-α-related apoptosis-inducing ligand) sensitizers. As a result of this study, two naphthoquinone epoxides, 2,3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bd1e43004e5d9db7ebe5b3a802d26a
https://doi.org/10.1021/np200805z
https://doi.org/10.1021/np200805z
Autor:
Cheryl L. Thomas, Emily L. Whitson, James B. McMahon, Tawnya C. McKee, Thomas J. Sayers, Curtis J. Henrich
Publikováno v:
Journal of Natural Products. 73:2013-2018
Casearia arguta was investigated as part of the ongoing search for synergistic TRAIL (tumor necrosis factor-α-related apoptosis-inducing ligand) sensitizers. As a result of this study, argutins A-H, eight new highly oxygenated clerodane diterpenes w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8b2d25b3786437f5ad5d9ea2812b9b
https://doi.org/10.1021/np1004455
https://doi.org/10.1021/np1004455
Autor:
Mary Kay Harper, Gina C. Mangalindan, Tim S. Bugni, Min He, Emily L. Whitson, Gisela P. Concepcion, Frank V. Ritacco, John N. A. Hooper, Priya S. Chockalingam, Chris M. Ireland
Publikováno v:
Journal of Natural Products
Three new sterol sulfates, spheciosterol sulfates A-C (1-3), and the known sterol sulfate topsentiasterol sulfate E (4) have been isolated from the sponge Spheciospongia sp., collected in the Philippines. Structures were assigned on the basis of exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397a72daefbf3d909e451d4bc38203d2
http://europepmc.org/articles/PMC2593898
http://europepmc.org/articles/PMC2593898
Publikováno v:
Planta Medica. 81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1db2e0a3c4940c20e7651b6cb08ffad9
https://doi.org/10.1055/s-0035-1556410
https://doi.org/10.1055/s-0035-1556410
Autor:
Daniel C. Rabe, Tanja Grkovic, James B. McMahon, Kirk R. Gustafson, Emily L. Whitson, Tawnya C. McKee, W. Marston Linehan, Donald P. Bottaro, Roberta S. Gardella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2113-2115
Kidney cancer was the cause of almost 13,000 deaths in the United States in 2009. Loss of function of the VHL tumor suppressor gene (von Hippel-Lindau disease) dramatically increases the risk of developing clear cell kidney cancer. The VHL protein is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fa500ba3dd5f9fdc029ce1d7d6264c
https://doi.org/10.1016/j.bmcl.2011.01.127
https://doi.org/10.1016/j.bmcl.2011.01.127
Autor:
James B. McMahon, Barry R. O'Keefe, Kirk R. Gustafson, Christophe Marchand, Yves Pommier, Edmund Price, Alun Bermingham, Emily L. Whitson
Publikováno v:
Planta Medica. 80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61c7071bcfed064915dafd8e076b0ca1
https://doi.org/10.1055/s-0034-1382735
https://doi.org/10.1055/s-0034-1382735
Publikováno v:
Cancer Drug Discovery and Development ISBN: 9781461491347
Natural product screening marries the search for new medicines with the search for new molecules from natural sources. The rationale for natural products as a source for new hits from which to develop new drugs will be discussed, and a brief overview
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddb13960606e749c978223765ec3c45b
https://doi.org/10.1007/978-1-4614-9135-4_3
https://doi.org/10.1007/978-1-4614-9135-4_3
Autor:
Daniel C. Rabe, Kirk R. Gustafson, W. Marston Linehan, Heidi R. Bokesch, Tawnya C. McKee, Emily L. Whitson, James B. McMahon, Donald P. Bottaro, Stephanie R. Marcum, Thushara Diyabalanage, Albert W. W. Van Wyk, Roberta S. Gardella, Tanja Grkovic
Publikováno v:
Planta Medica. 78
Renal or kidney cancer accounts for about 3% of all cancer cases reported each year in the U.S. Molecular signatures that define the cancer, such as the loss of functional VHL, are found in both sporadic and familial cases of cancer. In clear cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04d1ef8eebabaf9e3ab27f07ebe771e
https://doi.org/10.1055/s-0032-1320711
https://doi.org/10.1055/s-0032-1320711
Autor:
Han Sun, Kirk R. Gustafson, Emily L. Whitson, Christian Griesinger, Thomas J. Sayers, James B. McMahon, Cheryl L. Thomas, Tawnya C. McKee, Curtis J. Henrich
Publikováno v:
Planta Medica. 78
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cdff01fe92a91a7901070b50e7e8fa7
https://doi.org/10.1055/s-0032-1321295
https://doi.org/10.1055/s-0032-1321295