Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Emily L. Sylwestrak"'
Autor:
Emily L. Sylwestrak, YoungJu Jo, Sam Vesuna, Xiao Wang, Blake Holcomb, Rebecca H. Tien, Doo Kyung Kim, Lief Fenno, Charu Ramakrishnan, William E. Allen, Ritchie Chen, Krishna V. Shenoy, David Sussillo, Karl Deisseroth
Publikováno v:
Cell. 185(19)
Computational analysis of cellular activity has developed largely independently of modern transcriptomic cell typology, but integrating these approaches may be essential for full insight into cellular-level mechanisms underlying brain function and dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba84af4478fbc2e664a807167f3f784
https://pubmed.ncbi.nlm.nih.gov/36113428
https://pubmed.ncbi.nlm.nih.gov/36113428
Autor:
Matthew Wright, Sam Vesuna, Cindy Zang Liu, Emily L. Sylwestrak, Karl Deisseroth, Charu Ramakrishnan, Felice-Alessio Bava, Kathryn E. Evans, William E. Allen, Xiao Wang, Garry P. Nolan, Nikolay Samusik, Jia Liu
Publikováno v:
Science. 361
Transcriptome mapping in the 3D brain RNA sequencing samples the entire transcriptome but lacks anatomical information. In situ hybridization, on the other hand, can only profile a small number of transcripts. In situ sequencing technologies address
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c9396fcd66602757cee1118e4e8ed5
https://doi.org/10.1126/science.aat5691
https://doi.org/10.1126/science.aat5691
Autor:
Emily L. Sylwestrak, Anirvan Ghosh
Publikováno v:
Science. 338:536-540
On the Receiving End One type of neuron, the hippocampal pyramidal neuron, forms two different types of synapses with two different downstream partners. When the partner is an oriens-lacunosum moleculare (O-LM) interneuron, the pyramidal neuron only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62b0a5581158efef70aa0038080553f
https://doi.org/10.1126/science.1222482
https://doi.org/10.1126/science.1222482
Autor:
Patrick J. Drew, Kevin J. Bender, Lu Li, Emily L. Sylwestrak, Shantanu P. Jadhav, Daniel E. Feldman
Publikováno v:
Neuron. 64(4):537-549
Summary Type 1 cannabinoid (CB1) receptors mediate widespread synaptic plasticity, but how this contributes to systems-level plasticity and development in vivo is unclear. We tested whether CB1 signaling is required for development and plasticity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aed8eec64bb243a5600a115985a147f
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(3)
Synaptic scaling is a form of homeostatic synaptic plasticity characterized by cell-wide changes in synaptic strength in response to changes in overall levels of neuronal activity. Here we report that bicuculline-induced increase in neuronal activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c6cd5a565543ca57dc2b88527ab5a8
https://pubmed.ncbi.nlm.nih.gov/22262897
https://pubmed.ncbi.nlm.nih.gov/22262897
Publikováno v:
Neuroscience. 162(1)
The lateral parafascicular nucleus (lPf) is a member of the intralaminar thalamic nuclei, a collection of nuclei that characteristically provides widespread projections to the neocortex and basal ganglia and is associated with arousal, sensory, and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b194117d146db4c8229db12cb5175c46
https://pubmed.ncbi.nlm.nih.gov/19393292
https://pubmed.ncbi.nlm.nih.gov/19393292
Autor:
Peter Scheiffele, Emily L. Sylwestrak
Publikováno v:
Nature. 503:42-43
It emerges that a transcription program differentially regulates inhibitory inputs in distinct neuronal compartments — an unexpected coordinated switch for achieving experience-dependent 'plasticity' in neural circuits. See Letter p.121 Individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a0573dcb33b57f32f65c6ac062e1d5b
https://doi.org/10.1038/503042a
https://doi.org/10.1038/503042a
Publikováno v:
International Journal of Developmental Neuroscience. 26:846-846
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::486b21d93457e54fa5b1d200a0bb5345
https://doi.org/10.1016/j.ijdevneu.2008.09.065
https://doi.org/10.1016/j.ijdevneu.2008.09.065
Publikováno v:
The Journal of Neuroscience
Excitatory synapses onto somatostatin (SOM) interneurons show robust short-term facilitation. This hallmark feature of SOM interneurons arises from a low initial release probability that regulates the recruitment of interneurons in response to trains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc85d5da95c73963960415a647f539d
Autor:
Emily L. Sylwestrak, Katie Tiglio, Matthew L. O'Sullivan, Stefanie Otto, Joris de Wit, Jeffrey N. Savas, John R. Yates, Palmer Taylor, Anirvan Ghosh, Davide Comoletti
Publikováno v:
Neuron. (6):799-806
Summary We identify the leucine-rich repeat transmembrane protein LRRTM2 as a key regulator of excitatory synapse development and function. LRRTM2 localizes to excitatory synapses in transfected hippocampal neurons, and shRNA-mediated knockdown of LR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a04d26f86738fd821e72910c9cdbdf5