Výsledky vyhledávání - "Emily L. Nelson"

Characterization of determinants of genotypic and phenotypic resistance to enfuvirtide in baseline and on-treatment HIV-1 isolates

Autor: Mike Mink, Thomas J. Matthews, Donna K. Davison, Sarah M. Mosier, Ralph DeMasi, Lei Jin, Prakash Sista, Emily L. Nelson, Nick Cammack, Miklos Salgo, Michael L. Greenberg, Tom Melby

Publikováno v: AIDS. 18:1787-1794

Enfuvirtide (ENF) is the first of a novel class of drugs that block HIV gp41-mediated viral fusion to host cells. Viruses with mutations at positions 36-38 in HIV-1 gp41 and/or reduced susceptibility to ENF have been selected both in vitro and in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69aef78817afc9a2aa21433d34fa6b2
https://doi.org/10.1097/00002030-200409030-00007

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A phase II clinical study of the long-term safety and antiviral activity of enfuvirtide-based antiretroviral therapy

Autor: Margrit Carlson, Fred T. Valentine, Paul A. Volberding, Joel E. Gallant, Prakash R. Sista, Jacob Lalezari, J. Michael Kilby, Robert L. Murphy, Alex Dusek, Roberto C. Arduino, Calvin J. Cohen, Edwin DeJesus, Emily L. Nelson, Joseph J. Eron

Publikováno v: AIDS (London, England). 17(5)

Objectives The primary objective was to determine the long-term safety of the subcutaneous self-administration of enfuvirtide. Secondary objectives included the determination of enfuvirtide pharmacokinetics and antiviral activity and the immunologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633f39c870a270202ba3a0e198fdbc9d
https://pubmed.ncbi.nlm.nih.gov/15090785

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The safety, plasma pharmacokinetics, and antiviral activity of subcutaneous enfuvirtide (T-20), a peptide inhibitor of gp41-mediated virus fusion, in HIV-infected adults

Autor: Fred T. Valentine, J. Michael Kilby, Robert L. Murphy, Margrit Carlson, Alex Dusek, Jeffrey Goodgame, Emily L. Nelson, Joseph J. Eron, Calvin J. Cohen, Michael S. Saag, Paul A. Volberding, Jacob Lalezari, Roberto C. Arduino, Joel E. Gallant, Prakash R. Sista

Publikováno v: AIDS research and human retroviruses. 18(10)

Enfuvirtide (T-20) is a novel antiretroviral agent that blocks HIV-1 cell fusion. A 28-day randomized dose-comparison study was conducted to determine the safety, pharmacokinetics, and antiviral activity of enfuvirtide in 78 HIV-infected adults, most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adccf83c88f31aecc60f7ee61a55e84a
https://pubmed.ncbi.nlm.nih.gov/12167274

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