Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Emily K. Waters"'
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175030 (2017)
Canine models of severe haemophilia resemble their human equivalents both regarding clinical bleeding phenotype and response to treatment. Therefore pre-clinical studies in haemophilia dogs have allowed researchers to make valuable translational pred
Externí odkaz:
https://doaj.org/article/2939d22da65740519e111abd1932af27
Autor:
Scott Kahan, Skye Peltier, Kimberly Baumann, Robert F. Sidonio, Michelle Witkop, Emily K. Waters, David L. Cooper, Michael Wang
Publikováno v:
Haemophilia. 26:20-30
Background Despite the high prevalence of overweight and obesity in the United States, few studies have assessed the impact of obesity on haemophilia-specific outcomes or experiences/perceptions of healthcare providers (HCPs) treating haemophilia. Ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dacff32c12819b8c2121c5f6a9577a
https://doi.org/10.1111/hae.13919
https://doi.org/10.1111/hae.13919
Autor:
Erika J. Martin, Melinda E Nolte, Bassem M. Mohammed, Marisa Ninivaggi, John C. Barrett, Emily K. Waters, Janice Kuhn, Donald F. Brophy, Mirella Ezban
Publikováno v:
Haemophilia. 24:815-822
INTRODUCTION The thrombin generation assay (TGA) can be used to monitor factor replacement therapy in patients with haemophilia. The TGA assay is typically performed using tissue factor as the reaction activator; however, activating with FIXa or FXIa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10692feb42d0df92b3f91edf8909c805
https://doi.org/10.1111/hae.13597
https://doi.org/10.1111/hae.13597
Publikováno v:
Haemophilia. 23:769-776
Aims Concizumab, a humanized monoclonal antibody against tissue factor pathway inhibitor (TFPI), is being developed as a subcutaneously (s.c.) administered treatment for haemophilia. It demonstrated a concentration-dependent procoagulant effect in fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b85fbf14d6f30bc9d2eff1dd4b9b5c
https://doi.org/10.1111/hae.13260
https://doi.org/10.1111/hae.13260
Autor:
Erika J. Martin, Janice Kuhn, M. E. Nolte, John C. Barrett, Rune Salbo, Donald F. Brophy, Emily K. Waters, Jacob Lund, Heidi L. Holmberg, Bo Wiinberg, Bassem M. Mohammed
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 23(6)
Introduction The thrombomodulin (TM)/activated protein C (APC) system is a key regulator of haemostasis, limiting amplification and propagation of the formed blood clot to the injury site. Dampening APC's inhibition of factor V (FV) and factor VIII (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a48f747f8f352041130acfeb27d66d0
https://pubmed.ncbi.nlm.nih.gov/28750471
https://pubmed.ncbi.nlm.nih.gov/28750471
Autor:
Elizabeth P. Merricks, Daniel Elenius Madsen, Timothy C. Nichols, Bo Wiinberg, Emily K. Waters
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175030 (2017)
PLoS ONE
PLoS ONE
Introduction Canine models of severe haemophilia resemble their human equivalents both regarding clinical bleeding phenotype and response to treatment. Therefore pre-clinical studies in haemophilia dogs have allowed researchers to make valuable trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff27fbaab6e936a1621a50a82ee5668f
http://europepmc.org/articles/PMC5383133?pdf=render
http://europepmc.org/articles/PMC5383133?pdf=render
Autor:
Emily K. Waters, Jeffrey Kurz, Genga Ryan, Kathleen E. McGinness, F. Scheiflinger, Robert G. Schaub, H. A. Thomson
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 11(6)
Summary Background Tissue factor pathway inhibitor (TFPI) is a multidomain protein that negatively regulates the coagulation cascade. TFPI inhibits the tissue factor (TF)–activated factor VII–activated FX (FXa) complex during TF-mediated coagulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb8be1ce91d7fe7d8c4c30543703bb1
https://pubmed.ncbi.nlm.nih.gov/23528042
https://pubmed.ncbi.nlm.nih.gov/23528042
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 10(10)
Summary. Background: Upon contact with an appropriate surface, factor XII (FXII) undergoes autoactivation or cleavage by kallikrein. Zn2+ is known to facilitate binding of FXII and the cofactor, high molecular weight kininogen (HK), to anionic surfac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12af893f2974b6b735ab4171d3b2c473
https://pubmed.ncbi.nlm.nih.gov/22905925
https://pubmed.ncbi.nlm.nih.gov/22905925
Autor:
Robert G. Schaub, Jeffrey Kurz, Karen A. Olson, Michael C. Schwartz, Kathleen E. McGinness, Nelson Jennifer, Emily K. Waters, Genga Ryan
Publikováno v:
Blood. 117(20)
Hemophilia A and B are caused by deficiencies in coagulation factor VIII (FVIII) and factor IX, respectively, resulting in deficient blood coagulation via the intrinsic pathway. The extrinsic coagulation pathway, mediated by factor VIIa and tissue fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca844016268e980aaea78d094f4c8511
https://pubmed.ncbi.nlm.nih.gov/21596863
https://pubmed.ncbi.nlm.nih.gov/21596863
Autor:
J.-G. Geng, Emily K. Waters, Natasha S. Barteneva, Matthew J. Sullivan, Brian M. Steele, Patricia B. Maguire, Michael Bernimoulin, Denisa D. Wagner, John H. Hartwig, Hervé Falet, Meghan T. Walsh, Martina Foy
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 7(6)
Summary. Background: Microparticles (MPs), small vesicles shed from stimulated cells, permit cross-talk between cells within a particular environment. Their composition is thought to reflect their cell of origin, and differs according to whether they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f1681618eccd7b545a4d529d73f5f3
https://pubmed.ncbi.nlm.nih.gov/19548909
https://pubmed.ncbi.nlm.nih.gov/19548909