Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Emily K. Sims"'
Autor:
Jamie L. Felton, Maria J. Redondo, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Arianna Harris-Kawano, Dianna Perez, Zeb Saeed, Benjamin Hoag, Rashmi Jain, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, John M. Wentworth, Kurt J. Griffin, Emily K. Sims, On behalf of the ADA/EASD PMDI
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-18 (2024)
Abstract Background Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and
Externí odkaz:
https://doaj.org/article/113aed4f5d484c8ca50fd405d635e3a3
Autor:
Milene C. Vallejo, Soumyadeep Sarkar, Emily C. Elliott, Hayden R. Henry, Samantha M. Powell, Ivo Diaz Ludovico, Youngki You, Fei Huang, Samuel H. Payne, Sasanka Ramanadham, Emily K. Sims, Thomas O. Metz, Raghavendra G. Mirmira, Ernesto S. Nakayasu
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-14 (2023)
Abstract Extracellular vesicles play major roles in cell-to-cell communication and are excellent biomarker candidates. However, studying plasma extracellular vesicles is challenging due to contaminants. Here, we performed a proteomics meta-analysis o
Externí odkaz:
https://doaj.org/article/a7d72d2c446c44ff926f2c19bd0e61eb
Autor:
Jamie L. Felton, Kurt J. Griffin, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, ADA/EASD PMDI
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-16 (2023)
Abstract Background Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneit
Externí odkaz:
https://doaj.org/article/2767b39b5fa44f12be12f5096aacf63d
Autor:
Rebecca S. Aguirre, Abhishek Kulkarni, Matthew W. Becker, Xiaoyong Lei, Soumyadeep Sarkar, Sasanka Ramanadham, Edward A. Phelps, Ernesto S. Nakayasu, Emily K. Sims, Raghavendra G. Mirmira
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101545- (2022)
Background: Type 1 diabetes (T1D) is a complex autoimmune disorder whose pathogenesis involves an intricate interplay between β cells of the pancreatic islet, other islet cells, and cells of the immune system. Direct intercellular communication with
Externí odkaz:
https://doaj.org/article/678c7a50544c41d5811309036b14ae85
Autor:
Sara Ibrahim, Macey Johnson, Clarissa Hernandez Stephens, Jerry Xu, Rachel Moore, Andrea Mariani, Christopher Contreras, Farooq Syed, Raghavendra G. Mirmira, Ryan M. Anderson, Emily K. Sims
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101289- (2021)
Objective: β-cell microRNA-21 (miR-21) is increased by islet inflammatory stress but it decreases glucose-stimulated insulin secretion (GSIS). Thus, we sought to define the effects of miR-21 on β-cell function using in vitro and in vivo systems. Me
Externí odkaz:
https://doaj.org/article/d4546e0f597946beb741de5f5f20e400
Autor:
Sara Ibrahim, Arianna Harris-Kawano, Isra Haider, Raghavendra G. Mirmira, Emily K. Sims, Ryan M. Anderson
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 6 (2020)
Maladaptive signaling by pro-inflammatory cytokines (PICs), such as TNFα, IL1β and IFNɣ, can activate downstream signaling cascades that are implicated in the development and progression of multiple inflammatory diseases. Despite playing critical
Externí odkaz:
https://doaj.org/article/625e0bb3d77b484eb207a9d7b7bd3b8c
Autor:
Masayuki Hatanaka, Emily Anderson-Baucum, Alexander Lakhter, Tatsuyoshi Kono, Bernhard Maier, Sarah A. Tersey, Yukio Tanizawa, Carmella Evans-Molina, Raghavendra G. Mirmira, Emily K. Sims
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Under conditions of high fat diet (HFD) consumption, glucose dyshomeostasis develops when β-cells are unable to adapt to peripheral insulin demands. Few studies have interrogated the molecular mechanisms of β-cell dysfunction at the level
Externí odkaz:
https://doaj.org/article/55e51cc8fc5a42f3821a8cee071ffc18
Autor:
Rebecca K Davidson, Staci A Weaver, Nolan Casey, Sukrati Kanojia, Elise Hogarth, Rebecca Schneider Aguirre, Emily K Sims, Carmella Evans-Molina, Jason M Spaeth
Publikováno v:
J Mol Endocrinol
Type 2 diabetes (T2D) is associated with loss of transcription factors (TFs) from a subset of failing β-cells. Among these TFs is Pdx1, which controls the expression of numerous genes involved in maintaining β-cell function and identity. Pdx1 activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b6cf1d3f5ce8d9161120ca187f6ac2
https://doi.org/10.1530/jme-22-0011
https://doi.org/10.1530/jme-22-0011
Autor:
Kathleen M, Dungan, Phil A, Hart, Dana K, Andersen, Marina, Basina, Vernon M, Chinchilli, Kirstie K, Danielson, Carmella, Evans-Molina, Mark O, Goodarzi, Carla J, Greenbaum, Rita R, Kalyani, Maren R, Laughlin, Ariana, Pichardo-Lowden, Richard E, Pratley, Jose, Serrano, Emily K, Sims, Cate, Speake, Dhiraj, Yadav, Melena D, Bellin, Frederico G S, Toledo
Publikováno v:
Pancreas
OBJECTIVES: The metabolic abnormalities that lead to diabetes mellitus (DM) following an episode of acute pancreatitis (AP) have not been extensively studied. This manuscript describes the objectives, hypotheses, and methods of mechanistic studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5edad3e56048cd28b087edaba6943c
https://doi.org/10.1097/mpa.0000000000002074
https://doi.org/10.1097/mpa.0000000000002074
Autor:
Emily K. Sims, Linda A. DiMeglio
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp S129-S138 (2019)
Background: Limited successes of conventional approaches to type 1 diabetes (T1D) prevention and treatment have highlighted the need for improved understanding of risk factors contributing to or hastening progression to clinical diagnosis. Scope of r
Externí odkaz:
https://doaj.org/article/6e4f15713f044562965fc30e221f7583