Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Emily K. Pugach"'
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Background Myogenesis is driven by specific changes in the transcriptome that occur during the different stages of muscle differentiation. In addition to controlled transcriptional transitions, several other post-transcriptional mechanisms d
Externí odkaz:
https://doaj.org/article/d12eec12547b4d07aad1fca3d02682a0
Publikováno v:
Human Molecular Genetics. 27:2101-2112
Niemann-Pick type C (NPC) disease is a rare lysosomal storage disease caused primarily by mutations in NPC1. NPC1 encodes the lysosomal cholesterol transport protein NPC1. The most common NPC1 mutation is a missense mutation (NPC1(I1061T)) that cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0505c3c638ce89903222ec6f442729c
https://doi.org/10.1093/hmg/ddy117
https://doi.org/10.1093/hmg/ddy117
BackgroundMyogenesis is driven by specific changes in the transcriptome that occur during the different stages of muscle differentiation. In addition to controlled transcriptional transitions, several other post-transcriptional mechanisms direct musc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e86324e667d98307a566f90f42dd0a0
Autor:
Dipak Panigrahy, Owen J. Tamplin, Pulin Li, Elizabeth B. Riley, Jamie L. Lahvic, Francesca G. Barrett, Teresa V. Bowman, Leonard I. Zon, Darryl C. Zeldin, Thorsten M. Schlaeger, Vera Binder, George Q. Daley, Garrett C. Heffner, Emily K. Pugach, Shannon McKinney-Freeman
Publikováno v:
Nature. 573:E1-E1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d46f2dd0eb1555672cb4b281fb4c19d4
https://doi.org/10.1038/s41586-019-1489-4
https://doi.org/10.1038/s41586-019-1489-4
Autor:
Antony DiBiase, Narie Y. Storer, Eleanor Y. Chen, Leonard I. Zon, Xiuning Le, Kenneth D. Poss, Emily K. Pugach, Airon A. Wills, David M. Langenau, Simone Hettmer, Myron S. Ignatius, Jianing Liu, Amy J. Wagers
Publikováno v:
Development. 140:2354-2364
The zebrafish is a powerful genetic model that has only recently been used to dissect developmental pathways involved in oncogenesis. We hypothesized that operative pathways during embryogenesis would also be used for oncogenesis. In an effort to def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2c7fab29d9d819a5c6024d9925373d
https://doi.org/10.1242/dev.088427
https://doi.org/10.1242/dev.088427
Estrogen signaling appears critical in the heart. However a mechanistic understanding of the role of estrogen in the cardiac myocyte is lacking. Moreover, there are multiple cell types in the heart and multiple estrogen receptor (ER) isoforms. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982d680c1e07966cb7b14f25ee358dcc
https://europepmc.org/articles/PMC4899180/
https://europepmc.org/articles/PMC4899180/
Publikováno v:
Zebrafish. 7:61-68
cdx4, a caudal-related homeodomain-containing transcription factor, functions as a regulator of hox genes, thereby playing a critical role in anterior-posterior (A-P) patterning during embryogenesis. In zebrafish, homozygous deletion of the cdx4 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae945d213ecbfc835041fea8b39d0259
https://doi.org/10.1089/zeb.2009.0643
https://doi.org/10.1089/zeb.2009.0643
Autor:
Richard M. White, Yariv Houvras, Barry Baker, Christopher J. Burke, Anna Sessa, Emily K. Pugach, Leonard I. Zon, Rharaka Gilbert, A. Thomas Look
Publikováno v:
Zebrafish. 5:335-339
Captive zebrafish (Danio rerio) exhibit a limited repertoire of mating behaviors, likely due to the somewhat unnatural environment of aquaria. Observations in their natural habitat led us to believe that a depth gradient within the mating setup would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df7ac74d9c070579895bc79e017bdb8
https://doi.org/10.1089/zeb.2008.0535
https://doi.org/10.1089/zeb.2008.0535
Publikováno v:
Journal of molecular and cellular cardiology. 86
Studying the importance of genetic factors in a desired cell type or tissue necessitates the use of precise genetic tools. With the introduction of bacteriophage Cre recombinase/loxP mediated DNA editing and promoter-specific Cre expression, it is fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb133844a7e7c00e9b0de0b7da75f64
https://pubmed.ncbi.nlm.nih.gov/26141530
https://pubmed.ncbi.nlm.nih.gov/26141530
Publikováno v:
Skeletal Muscle
Background microRNA regulation plays an important role in the remodeling that occurs in response to pathologic and physiologic stimuli in skeletal muscle. In response to stress, microRNAs are dynamically regulated, resulting in a widespread “fine-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2945ea5cb2e5995d4d879b8b9df5139e
https://doi.org/10.1186/2044-5040-3-19
https://doi.org/10.1186/2044-5040-3-19