Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function

Autor: Luke Yi Hao, Shalom Lerrer, Matthieu Paiola, Emily K. Moore, Yevgeniya Gartshteyn, Ruijiang Song, Michael Goeckeritz, Matilda J. Black, Shoiab Bukhari, Xizi Hu, Adam Mor

Publikováno v: Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200839- (2024)

Targeting immune checkpoint receptors on T cells is a common cancer treatment strategy. Frequently, this is accomplished through antibodies targeting the ligand of inhibitory co-receptors. Blocking the immune checkpoint PD-1 binding to its ligands PD

Externí odkaz: https://doaj.org/article/0741c235bba34d5a89e9254a5a2bc2e7

An ELF4 hypomorphic variant results in NK cell deficiency

Autor: Sandra Andrea Salinas, Emily M. Mace, Matilde I. Conte, Chun Shik Park, Yu Li, Joshua I. Rosario-Sepulveda, Sanjana Mahapatra, Emily K. Moore, Evelyn R. Hernandez, Ivan K. Chinn, Abigail E. Reed, Barclay J. Lee, Alexander Frumovitz, Richard A. Gibbs, Jennifer E. Posey, Lisa R. Forbes Satter, Akaluck Thatayatikom, Eric J. Allenspach, Theodore G. Wensel, James R. Lupski, H. Daniel Lacorazza, Jordan S. Orange

Publikováno v: JCI Insight, Vol 7, Iss 23 (2022)

NK cell deficiencies (NKD) are a type of primary immune deficiency in which the major immunologic abnormality affects NK cell number, maturity, or function. Since NK cells contribute to immune defense against virally infected cells, patients with NKD

Externí odkaz: https://doaj.org/article/e8ed5f88210742fab09bd2ee0e25144a

The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity

Autor: Patricia Ho, Johannes C. Melms, Meri Rogava, Chris J. Frangieh, Shivem B. Shah, Zachary Walsh, Oleksandr Kyrysyuk, Amit Dipak Amin, Lindsay Caprio, Benjamin T. Fullerton, Rajesh Soni, Casey R. Ager, Jana Biermann, Yiping Wang, Michael Mu, Hijab Fatima, Emily K. Moore, Neil Vasan, Samuel F. Bakhoum, Steven L. Reiner, Chantale Bernatchez, Emily M. Mace, Kai W. Wucherpfennig, Dirk Schadendorf, Gary K. Schwartz, Benjamin Izar

The cell autonomous balance of immune-inhibitory and -stimulatory signals is a critical yet poorly understood process in cancer immune evasion. Using patient-derived co-culture models and humanized mouse models, we show that an intact CD58:CD2 intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::247a8c3317edc795cbabee19eee97416
https://doi.org/10.1101/2022.03.21.485049

Prolonged exposure to simulated microgravity diminishes dendritic cell immunogenicity

Autor: Jillian Bradley, Randal K. Gregg, Emily K. Moore, Nichole Tackett, Stefanie H. Baker, Stephanie L. Minter, Brian DiGiacinto, Jennifer P. Arnold

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports

Immune dysfunction due to microgravity remains a hurdle in the next step of human space exploration. Dendritic cells (DC) represent a critical component of immunity, given their role in the detection of invaders and the subsequent task of activating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b1b02fe050eaa32f17fbbb3526299e
http://link.springer.com/article/10.1038/s41598-019-50311-z

Habitat impact assessment detects spatially driven patterns of grazing impacts in habitat mosaics but overestimates damage

Autor: Robin J. Pakeman, Jenny Bryce, Nikki Dayton, Josephine M. Pemberton, Emily K. Moore, Andrea J. Britton, Glenn R. Iason

Publikováno v: Moore, E K, Iason, G R, Pemberton, J M, Bryce, J, Dayton, N, Britton, A J & Pakeman, R J 2018, ' Habitat impact assessment detects spatially driven patterns of grazing impacts in habitat mosaics but overestimates damage ', Journal for nature conservation, vol. 45, pp. 20-29 . https://doi.org/10.1016/j.jnc.2018.07.005

Many habitats of conservation importance are grazed by large herbivores, but spatial variation in grazing intensity can complicate management planning. We tested the effect of local herbivore density and the proximity of alternative preferred plant c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197693c5db971e85c3907f276642754a
https://www.pure.ed.ac.uk/ws/files/79630966/Habitat_Impact_Assessment_AAM_JNC_2018_77_Revision2_clean.docx