Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Emily K. Moore"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 380-390 (2022)
The transmembrane adaptor phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG) is phosphorylated in T cells downstream of PD-1 signaling and contributes to the resulting functional inhibition of multiple cellular processes.
Externí odkaz:
https://doaj.org/article/7b309f1b92964a77bed8276d7e43199e
Autor:
Sandra Andrea Salinas, Emily M. Mace, Matilde I. Conte, Chun Shik Park, Yu Li, Joshua I. Rosario-Sepulveda, Sanjana Mahapatra, Emily K. Moore, Evelyn R. Hernandez, Ivan K. Chinn, Abigail E. Reed, Barclay J. Lee, Alexander Frumovitz, Richard A. Gibbs, Jennifer E. Posey, Lisa R. Forbes Satter, Akaluck Thatayatikom, Eric J. Allenspach, Theodore G. Wensel, James R. Lupski, H. Daniel Lacorazza, Jordan S. Orange
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
NK cell deficiencies (NKD) are a type of primary immune deficiency in which the major immunologic abnormality affects NK cell number, maturity, or function. Since NK cells contribute to immune defense against virally infected cells, patients with NKD
Externí odkaz:
https://doaj.org/article/e8ed5f88210742fab09bd2ee0e25144a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cancer remains the second leading cause of death in the US, accounting for 25% of all deaths nationwide. Immunotherapy techniques bolster the immune cells’ ability to target malignant cancer cells and have brought immense improvements in the field
Externí odkaz:
https://doaj.org/article/6df989a83dbe47dd920777ee48f3e48a
Autor:
Patricia Ho, Johannes C. Melms, Meri Rogava, Chris J. Frangieh, Shivem B. Shah, Zachary Walsh, Oleksandr Kyrysyuk, Amit Dipak Amin, Lindsay Caprio, Benjamin T. Fullerton, Rajesh Soni, Casey R. Ager, Jana Biermann, Yiping Wang, Michael Mu, Hijab Fatima, Emily K. Moore, Neil Vasan, Samuel F. Bakhoum, Steven L. Reiner, Chantale Bernatchez, Emily M. Mace, Kai W. Wucherpfennig, Dirk Schadendorf, Gary K. Schwartz, Benjamin Izar
The cell autonomous balance of immune-inhibitory and -stimulatory signals is a critical yet poorly understood process in cancer immune evasion. Using patient-derived co-culture models and humanized mouse models, we show that an intact CD58:CD2 intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::247a8c3317edc795cbabee19eee97416
https://doi.org/10.1101/2022.03.21.485049
https://doi.org/10.1101/2022.03.21.485049
Autor:
Jillian Bradley, Randal K. Gregg, Emily K. Moore, Nichole Tackett, Stefanie H. Baker, Stephanie L. Minter, Brian DiGiacinto, Jennifer P. Arnold
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Immune dysfunction due to microgravity remains a hurdle in the next step of human space exploration. Dendritic cells (DC) represent a critical component of immunity, given their role in the detection of invaders and the subsequent task of activating
Autor:
Sandra Andrea Salinas, Emily M. Mace, Matilde I. Conte, Chun Shik Park, Yu Li, Joshua I. Rosario-Sepulveda, Sanjana Mahapatra, Emily K. Moore, Evelyn R. Hernandez, Ivan K. Chinn, Abigail E. Reed, Barclay J. Lee, Alexander Frumovitz, Richard A. Gibbs, Jennifer E. Posey, Lisa R. Forbes Satter, Akaluck Thatayatikom, Eric J. Allenspach, Theodore G. Wensel, James R. Lupski, H. Daniel Lacorazza, Jordan S. Orange
Publikováno v:
JCI insight. 7(23)
NK cell deficiencies (NKD) are a type of primary immune deficiency in which the major immunologic abnormality affects NK cell number, maturity, or function. Since NK cells contribute to immune defense against virally infected cells, patients with NKD
Autor:
Robin J. Pakeman, Jenny Bryce, Nikki Dayton, Josephine M. Pemberton, Emily K. Moore, Andrea J. Britton, Glenn R. Iason
Publikováno v:
Moore, E K, Iason, G R, Pemberton, J M, Bryce, J, Dayton, N, Britton, A J & Pakeman, R J 2018, ' Habitat impact assessment detects spatially driven patterns of grazing impacts in habitat mosaics but overestimates damage ', Journal for nature conservation, vol. 45, pp. 20-29 . https://doi.org/10.1016/j.jnc.2018.07.005
Many habitats of conservation importance are grazed by large herbivores, but spatial variation in grazing intensity can complicate management planning. We tested the effect of local herbivore density and the proximity of alternative preferred plant c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197693c5db971e85c3907f276642754a
https://www.pure.ed.ac.uk/ws/files/79630966/Habitat_Impact_Assessment_AAM_JNC_2018_77_Revision2_clean.docx
https://www.pure.ed.ac.uk/ws/files/79630966/Habitat_Impact_Assessment_AAM_JNC_2018_77_Revision2_clean.docx
Publikováno v:
Biological Conservation. 192:218-225
Understanding the distribution of herbivory is of great importance to planning the conservation management of plant communities. Control of wild and domestic large herbivore populations at large scales is commonly used to manipulate their impacts. Ho
Autor:
Emily M. Mace, Nermina Saucier, Emily K. Jeng, Hing C. Wong, Sandeep K. Agarwal, Sandeep K. Tripathy, Jeffrey S. Miller, Emily K. Moore, Anthony R. French, Armin Rashidi, Joshua B. Alinger, Annelise Y. Mah, Molly P. Keppel, Megan A. Cooper, Todd A. Fehniger
Publikováno v:
JCI Insight. 2
NK cell activation has been shown to be metabolically regulated in vitro; however, the role of metabolism during in vivo NK cell responses to infection is unknown. We examined the role of glycolysis in NK cell function during murine cytomegalovirus (
Autor:
Katy Orford, Rob W. Brooker, Richard L. Hewison, Robin J. Pakeman, Jim Alexander, Clare Pemberton, Sarah Gore, Rob J. Lewis, Roger P. Cummins, Ruth J. Mitchell, Emily K. Moore, Debbie A. Fielding, Clare J. Trinder
Publikováno v:
Pakeman, R J, Brooker, R, Alexander, J, Cummins, R, Fielding, D, Gore, S, Hewison, R, Mitchell, R, Moore, E, Orford, K, Pemberton, C, Trinder, C & Lewis, R 2016, ' Long-term impacts of nitrogen deposition on coastal plant communities ', Environmental Pollution, vol. 212, pp. 337-347 . https://doi.org/10.1016/j.envpol.2016.01.084
Nitrogen deposition has been shown to have significant impacts on a range of vegetation types resulting in eutrophication and species compositional change. Data from a re-survey of 89 coastal sites in Scotland, UK, c. 34 years after the initial surve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d7319bdb6543c7738d1a8fa1e6f3e2
https://pure.au.dk/portal/da/publications/longterm-impacts-of-nitrogen-deposition-on-coastal-plant-communities(8fb2db90-a4f1-4e56-85f9-09f7e27ccb73).html
https://pure.au.dk/portal/da/publications/longterm-impacts-of-nitrogen-deposition-on-coastal-plant-communities(8fb2db90-a4f1-4e56-85f9-09f7e27ccb73).html