Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Emily K Kleczko"'
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Akademický článek
Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer
Autor: Emily K Kleczko, Raphael A Nemenoff, Michael William Knitz
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Resistance to therapy is a major problem in treating head and neck squamous cell carcinomas (HNSCC). Complement system inhibition has been shown to reduce tumor growth, metastasis, and therapeutic resistance in other tumor models, but has
Externí odkaz: https://doaj.org/article/7b398750e9264d619aeb8badf15634ac
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2
Akademický článek
An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.
Autor: Emily K Kleczko, Jihye Kim, Stephen B Keysar, Lydia R Heasley, Justin R Eagles, Matthew Simon, Marianne E Marshall, Katherine R Singleton, Antonio Jimeno, Aik-Choon Tan, Lynn E Heasley
Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0123600 (2015)
The epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of head and neck squamous cell carcinomas (HNSCC), and molecularly targeted therapy against the EGFR with the monoclonal antibody cetuximab modestly increases overall s
Externí odkaz: https://doaj.org/article/a82ad2317a424efca73d9196cdef2d0b
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3
Data Supplement from Nonamplified FGFR1 Is a Growth Driver in Malignant Pleural Mesothelioma
Autor: Lynn E. Heasley, Sven Perner, Joseph M. Gozgit, Arne Warth, Hans Hoffmann, Raphael A. Nemenoff, Mary C. Weiser-Evans, Diana Boehm, Emily K. Kleczko, Kyle A. Olszewski, Anne von Mässenhausen, Trista K. Hinz, Lindsay A. Marek
Figure S1. Fluorescence in situ hybridization (FISH) analysis of FGFR1 gene copy number status in mesothelioma cell lines. Figure S2. Bioluminescence imaging of orthotopically implanted H226 tumors treated with or without ponatinib. Supplementary Tab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72aaca3af0c29d5b3500aecdfa0171b1
https://doi.org/10.1158/1541-7786.22514688.v1
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4
Data from Activation of PPARγ in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGFβ1
Autor: Raphael A. Nemenoff, Mary C. Weiser-Evans, Emily K. Kleczko, Jeff W. Kwak, Joanna M. Poczobutt, Bonnie L. Bullock, Teresa T. Nguyen, Dwight Hanson, Howard Y. Li, Amber M. Johnson, Trisha R. Sippel
Lung cancer is a heterogeneous disease in which patient-specific treatments are desirable and the development of targeted therapies has been effective. Although mutations in KRAS are frequent in lung adenocarcinoma, there are currently no targeted ag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93d4a05dbf3de9fd90b2006695996f89
https://doi.org/10.1158/1541-7786.c.6541266
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9
Data from Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC
Autor: Lynn E. Heasley, Aik Choon Tan, Jihye Kim, Taylor Harp, Jeff Kwak, Lindsay A. Marek, Emily K. Kleczko, Trista K. Hinz, Katherine R. Singleton
The FGFR1 is a therapeutic target under investigation in multiple solid tumors and clinical trials of selective tyrosine kinase inhibitors (TKI) are underway. Treatment with a single TKI represents a logical step toward personalized cancer therapy, b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be727a20df2fa3f3579e6b9b52cbc6c1
https://doi.org/10.1158/0008-5472.c.6507188
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10
Supplementary Methods, Figures S1-S12, Tables S1-S2 from Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC
Autor: Lynn E. Heasley, Aik Choon Tan, Jihye Kim, Taylor Harp, Jeff Kwak, Lindsay A. Marek, Emily K. Kleczko, Trista K. Hinz, Katherine R. Singleton
Supplementary Methods, Figures S1-S12, Tables S1-S2. Figure S1. Overview of workflow for the synthetic lethal and essential gene screens. Figure S2. Procedure for isolating and barcoding PCR-amplified shRNA sequences. Figure S3. Growth inhibition of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9c5ea9fa41662a0caa1f635af5d1f2
https://doi.org/10.1158/0008-5472.22406918.v1
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