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Akademický článek

Mutant human FUS Is ubiquitously mislocalized and generates persistent stress granules in primary cultured transgenic zebrafish cells.

Autor: Jamie Rae Acosta, Claire Goldsbury, Claire Winnick, Andrew P Badrock, Stuart T Fraser, Angela S Laird, Thomas E Hall, Emily K Don, Jennifer A Fifita, Ian P Blair, Garth A Nicholson, Nicholas J Cole

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e90572 (2014)

FUS mutations can occur in familial amyotrophic lateral sclerosis (fALS), a neurodegenerative disease with cytoplasmic FUS inclusion bodies in motor neurons. To investigate FUS pathology, we generated transgenic zebrafish expressing GFP-tagged wild-t

Externí odkaz: https://doaj.org/article/2310ea556cbd4b9d9e565e5e97d0b6ed

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Akademický článek

Development and evolution of the muscles of the pelvic fin.

Autor: Nicholas J Cole, Thomas E Hall, Emily K Don, Silke Berger, Catherine A Boisvert, Christine Neyt, Rolf Ericsson, Jean Joss, David B Gurevich, Peter D Currie

Publikováno v: PLoS Biology, Vol 9, Iss 10, p e1001168 (2011)

Locomotor strategies in terrestrial tetrapods have evolved from the utilisation of sinusoidal contractions of axial musculature, evident in ancestral fish species, to the reliance on powerful and complex limb muscles to provide propulsive force. With

Externí odkaz: https://doaj.org/article/34b3fff9a0544ac8a4df7cba642121d9

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Akademický článek

The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

Autor: Sonam Parakh, Sina Shadfar, Emma R. Perri, Audrey M.G. Ragagnin, Claudia V. Piattoni, Mariela B. Fogolín, Kristy C. Yuan, Hamideh Shahheydari, Emily K. Don, Collen J. Thomas, Yuning Hong, Marcelo A. Comini, Angela S. Laird, Damian M. Spencer, Julie D. Atkin

Publikováno v: iScience, Vol 23, Iss 5, Pp - (2020)

Summary: Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in almost all cases of amyotrophic lateral sclerosis (ALS), and 20% of familial ALS cases are due to mutations in superoxide dismutase 1 (SOD1). Redox regulation is critic

Externí odkaz: https://doaj.org/article/5d7c8645d1a843979d2e77a8fb26be55

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Akademický článek

Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo

Autor: Isabel Formella, Adam J. Svahn, Rowan A.W. Radford, Emily K. Don, Nicholas J. Cole, Alison Hogan, Albert Lee, Roger S. Chung, Marco Morsch

Publikováno v: Redox Biology, Vol 19, Iss , Pp 226-234 (2018)

Generation of reactive oxygen species (ROS) has been shown to be important for many physiological processes, ranging from cell differentiation to apoptosis. With the development of the genetically encoded photosensitiser KillerRed (KR) it is now poss

Externí odkaz: https://doaj.org/article/2d3e49ebf54b48fcaaf107a249f8872b

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Akademický článek

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex

Publikováno v: Open Biology, Vol 7, Iss 10 (2017)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and muscle loss often resulting in patient death within 3–5 years of diagnosis. Recently, we identified disease-linke

Externí odkaz: https://doaj.org/article/de64dd65912e44579c028274a46fd196

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Microglia morphophysiological diversity and its implications for the CNS

Autor: Andrés Vidal-Itriago, Rowan A. W. Radford, Jason A. Aramideh, Cindy Maurel, Natalie M. Scherer, Emily K. Don, Albert Lee, Roger S. Chung, Manuel B. Graeber, Marco Morsch

Publikováno v: Frontiers in immunology. 13

Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central nervous system (CNS) during the early stages of embryonic development. After colonizing the CNS, they proliferate and remain able to self-renew throughout life, mai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f123e42cff45dbf1dde534c8e1b50e8d
https://pubmed.ncbi.nlm.nih.gov/36341385

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Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3

Autor: Katherine J. Robinson, Alison L. Hogan, Stuart K. Plenderleith, Angela S. Laird, Madelaine C. Tym, Maxinne Watchon, Kristy C. Yuan, Emily K. Don

Publikováno v: Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record

Spinocerebellar ataxia 3 (SCA3, also known as Machado–Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a528967a97e959142254943c16940e6
https://doi.org/10.1242/dmm.049023

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Akademický článek

In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord

Autor: Marco eMorsch, Rowan eRadford, Albert eLee, Emily K. Don, Andrew Paul Badrock, Thomas E. Hall, Nicholas James Cole, Roger eChung

Publikováno v: Frontiers in Cellular Neuroscience, Vol 9 (2015)

Microglia are specialized phagocytes in the vertebrate central nervous system (CNS). As the resident immune cells of the CNS they play an important role in the removal of dying neurons during both development and in several neuronal pathologies. Micr

Externí odkaz: https://doaj.org/article/974517ac231e426daea40b088f6265a0

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