Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Emily J. Rundlet"'
Autor:
Manuel F Juette, Jordan D Carelli, Emily J Rundlet, Alan Brown, Sichen Shao, Angelica Ferguson, Michael R Wasserman, Mikael Holm, Jack Taunton, Scott C Blanchard
Publikováno v:
eLife, Vol 11 (2022)
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-1 alpha (eE
Externí odkaz:
https://doaj.org/article/8f80b5c7131340bf8719fcfe6bafffa4
Autor:
M. Gordon Joyce, Amy Bao, Man Chen, Ivelin S. Georgiev, Li Ou, Tatsiana Bylund, Aliaksandr Druz, Wing-Pui Kong, Dongjun Peng, Emily J. Rundlet, Joseph G. Van Galen, Shuishu Wang, Yongping Yang, Baoshan Zhang, Gwo-Yu Chuang, Jason S. McLellan, Barney S. Graham, John R. Mascola, Peter D. Kwong
Publikováno v:
Pathogens and Immunity, Vol 4, Iss 2, Pp 294-323 (2019)
Background: Respiratory syncytial virus (RSV) subtypes, A and B, co-circulate in annual epidemics and alternate in dominance. We have shown that a subtype A RSV fusion (F) glycoprotein, stabilized in its prefusion conformation by DS-Cav1 mutations, i
Externí odkaz:
https://doaj.org/article/aa9225bfc40c4f49a0f6918637f4fc7d
Autor:
Mikael Holm, S. Kundhavai Natchiar, Emily J. Rundlet, Alexander G. Myasnikov, Zoe L. Watson, Roger B. Altman, Hao-Yuan Wang, Jack Taunton, Scott C. Blanchard
Publikováno v:
Nature. 617:200-207
In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives principally from studies on bacterial systems1. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd353b00676a97d2a2634ea6967f4a06
https://doi.org/10.1038/s41586-023-05908-w
https://doi.org/10.1038/s41586-023-05908-w
Autor:
Julia Flis, Mikael Holm, Emily J. Rundlet, Justus Loerke, Tarek Hilal, Marylena Dabrowski, Jörg Bürger, Thorsten Mielke, Scott C. Blanchard, Christian M.T. Spahn, Tatyana V. Budkevich
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2676-2688.e7 (2018)
Summary: Translocation moves the tRNA2⋅mRNA module directionally through the ribosome during the elongation phase of protein synthesis. Although translocation is known to entail large conformational changes within both the ribosome and tRNA substra
Externí odkaz:
https://doaj.org/article/2865020d75fd4c0b8a1c8de64eb95a4d
Autor:
Emily J Rundlet, Jordan D Carelli, Manuel F Juette, Alan Brown, Sichen Shao, Angelica Ferguson, Michael R Wasserman, Mikael Holm, Jack Taunton, Scott C Blanchard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f283d1488342aeaee8a063972c7671b3
https://doi.org/10.7554/elife.81608.sa2
https://doi.org/10.7554/elife.81608.sa2
Autor:
Wataru Nishima, Dylan Girodat, Mikael Holm, Emily J Rundlet, Jose L Alejo, Kara Fischer, Scott C Blanchard, Karissa Y Sanbonmatsu
Publikováno v:
Nucleic Acids Res
Translocation of messenger RNA (mRNA) and transfer RNA (tRNA) substrates through the ribosome during protein synthesis, an exemplar of directional molecular movement in biology, entails a complex interplay of conformational, compositional, and chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c003ca8e4a001aea2d8bef962d4aff9c
https://europepmc.org/articles/PMC9371933/
https://europepmc.org/articles/PMC9371933/
Autor:
Christopher J. Bley, Si Nie, George W. Mobbs, Stefan Petrovic, Anna T. Gres, Xiaoyu Liu, Somnath Mukherjee, Sho Harvey, Ferdinand M. Huber, Daniel H. Lin, Bonnie Brown, Aaron W. Tang, Emily J. Rundlet, Ana R. Correia, Shane Chen, Saroj G. Regmi, Taylor A. Stevens, Claudia A. Jette, Mary Dasso, Alina Patke, Alexander F. Palazzo, Anthony A. Kossiakoff, André Hoelz
Publikováno v:
Science (New York, N.Y.). 376(6598)
INTRODUCTIONThe subcellular compartmentalization of eukaryotic cells requires selective transport of folded proteins and protein–nucleic acid complexes. Embedded in nuclear envelope pores, which are generated by the circumscribed fusion of the inne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d66691a34cb3dd35cafaab2561b734
https://pubmed.ncbi.nlm.nih.gov/35679398
https://pubmed.ncbi.nlm.nih.gov/35679398
Autor:
Maximiliane Wieland, Mikael Holm, Emily J. Rundlet, Martino Morici, Timm O. Koller, Tinashe P. Maviza, Domen Pogorevc, Ilya A. Osterman, Rolf Müller, Scott C. Blanchard, Daniel N. Wilson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(19)
Argyrins are a family of naturally produced octapeptides that display promising antimicrobial activity against Pseudomonas aeruginosa. Argyrin B (ArgB) has been shown to interact with an elongated form of the translation elongation factor G (EF-G), l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ba16944e0196313ba255a0c8813cf0
https://pubmed.ncbi.nlm.nih.gov/35500116
https://pubmed.ncbi.nlm.nih.gov/35500116
Autor:
Dylan J. Girodat, Wataru Nishima, Mikael Holm, Emily J. Rundlet, Jigneshkumar D. Prajapati, Jose L. Alejo Amaya, Kara Fischer, Scott C. Blanchard, Karissa Y. Sanbonmatsu
Publikováno v:
Biophysical Journal. 122:360a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a367155055ad6eb8583a1e892c478bdf
https://doi.org/10.1016/j.bpj.2022.11.1990
https://doi.org/10.1016/j.bpj.2022.11.1990
Autor:
Anthony A. Kossiakoff, Ferdinand M. Huber, Mary Dasso, Emily J. Rundlet, Saroj G. Regmi, Anna T. Gres, Alina Patke, Alexander F. Palazzo, George W. Mobbs, Daniel H. Lin, Somnath Mukherjee, Sho Harvey, Christopher J. Bley, Xiaoyu Liu, André Hoelz, Bonnie Brown, Ana R. Correia, Aaron W. Tang, Stefan Petrovic, Shane Chen, Si Nie
The nuclear pore complex (NPC) is the sole bidirectional gateway for nucleocytoplasmic transport. Despite recent progress in elucidating the NPC symmetric core architecture, the asymmetrically decorated cytoplasmic face, essential for mRNA export and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6421e1976bd726cc0e8c631f4edd780c
https://doi.org/10.1101/2021.10.26.465790
https://doi.org/10.1101/2021.10.26.465790