Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Emily J. Rowling"'
Autor:
Michael P Smith, Emily J Rowling, Zsofia Miskolczi, Jennifer Ferguson, Loredana Spoerri, Nikolas K Haass, Olivia Sloss, Sophie McEntegart, Imanol Arozarena, Alex von Kriegsheim, Javier Rodriguez, Holly Brunton, Jivko Kmarashev, Mitchell P Levesque, Reinhard Dummer, Dennie T Frederick, Miles C Andrews, Zachary A Cooper, Keith T Flaherty, Jennifer A Wargo, Claudia Wellbrock
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1011-1029 (2017)
Abstract Approaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a “MITF‐high” phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also conta
Externí odkaz:
https://doaj.org/article/7cabb6c3861544079d79157438ec0d09
Autor:
Michael P, Smith, Sareena, Rana, Jennifer, Ferguson, Emily J, Rowling, Keith T, Flaherty, Jennifer A, Wargo, Richard, Marais, Claudia, Wellbrock
Publikováno v:
Pigment Cell & Melanoma Research
The BRAF kinase and the MAPK pathway are targets of current melanoma therapies. However, MAPK pathway inhibition results in dynamic changes of downstream targets that can counteract inhibitor‐action not only in during treatment, but also in acquire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7574d83feb307fbd2c0d82003c2f118a
https://pubmed.ncbi.nlm.nih.gov/30277012
https://pubmed.ncbi.nlm.nih.gov/30277012
Autor:
Zsofia, Miskolczi, Michael P, Smith, Emily J, Rowling, Jennifer, Ferguson, Jorge, Barriuso, Claudia, Wellbrock
Publikováno v:
Oncogene
Despite the general focus on an invasive and de-differentiated phenotype as main driver of cancer metastasis, in melanoma patients many metastatic lesions display a high degree of pigmentation, indicative for a differentiated phenotype. Indeed, studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4519b6471bbb92e51abac398dda1c44
https://pubmed.ncbi.nlm.nih.gov/29545604
https://pubmed.ncbi.nlm.nih.gov/29545604
Autor:
Gavin Brown, Muhammad Babur, Alison Smigova, Christopher Cawthorne, Kaye J. Williams, Paul Birkket, Manikandan Kadirvel, Emily J. Rowling, Michael Fairclough, Adam McMahon, Sally Freeman
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:341-349
The diethyl ester of [(18)F]ML-10 is a small molecule apoptotic PET probe for cancer studies. Here we report a novel multi-step synthesis of the diethyl ester of ML-10 in excellent yields via fluorination using Xtal-Fluor-E. In addition, a one-pot ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb2d029480028deca027fa40e2445bd3
https://doi.org/10.1016/j.bmc.2013.11.019
https://doi.org/10.1016/j.bmc.2013.11.019
Autor:
Sophie Ridsdale, Melissa Mejin, Julia Resch, Emily J. Rowling, Kaye J. Williams, Muhammad Babur, Natalie Burrows, Georg Brabant
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism; Vol 96
The Journal of Clinical Endocrinology & Metabolism
The Journal of Clinical Endocrinology & Metabolism
Phosphoinositide 3-kinase (PI3K) regulates the transcription factor hypoxia-inducible factor-1 (HIF-1) in thyroid carcinoma cells. Both pathways are associated with aggressive phenotype in thyroid carcinomas.Our objective was to assess the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a2b2277b2b7af2a4a51fd7effb18bd
Autor:
Claudia Wellbrock, Holly Brunton, Keith T. Flaherty, Zachary A. Cooper, Michael P. Smith, Jennifer A. Wargo, Emily J. Rowling, Maria Romina Girotti, Reinhard Dummer, Richard Marais
Publikováno v:
European Journal of Cancer. 61:S2-S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc875091c87a76dc9378679c3aafffd8
https://doi.org/10.1016/s0959-8049(16)61005-5
https://doi.org/10.1016/s0959-8049(16)61005-5
Autor:
Manikandan, Kadirvel, Michael, Fairclough, Christopher, Cawthorne, Emily J, Rowling, Muhammad, Babur, Adam, McMahon, Paul, Birkket, Alison, Smigova, Sally, Freeman, Kaye J, Williams, Gavin, Brown
Publikováno v:
Bioorganicmedicinal chemistry. 22(1)
The diethyl ester of [(18)F]ML-10 is a small molecule apoptotic PET probe for cancer studies. Here we report a novel multi-step synthesis of the diethyl ester of ML-10 in excellent yields via fluorination using Xtal-Fluor-E. In addition, a one-pot ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1523dad921b839e0a93b6870621e16ed
https://pubmed.ncbi.nlm.nih.gov/24290974
https://pubmed.ncbi.nlm.nih.gov/24290974
Publikováno v:
European Journal of Cancer. 61:S98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e30e2cf192c8669e1e04d0aff54efff1
https://doi.org/10.1016/s0959-8049(16)61344-8
https://doi.org/10.1016/s0959-8049(16)61344-8
Autor:
W. Vermi, Adam Hurlstone, Claudia Wellbrock, Emily J. Rowling, N. Luheshi, H. Young, M. Bugatti, Michael P. Smith
Publikováno v:
European Journal of Cancer. 61:S67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3126626e96c2bce30bf57bfae9920eb6
https://doi.org/10.1016/s0959-8049(16)61232-7
https://doi.org/10.1016/s0959-8049(16)61232-7
Autor:
Nicola J. Curtin, Richard J. Edmondson, Tao Chen, Jann N. Sarkaria, Lan Z. Wang, Emily J. Rowling, A. Hopkins, Gary S. Beale, Suzanne Kyle, W. A. Cliby, A. Peasland
Publikováno v:
British Journal of Cancer
Background The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled replication forks and DNA damage to cell cycle checkpoints and DNA repair. It has long been recognised as an important target for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44619f44079bf98921e80abc38805bb3
https://pubmed.ncbi.nlm.nih.gov/21730979
https://pubmed.ncbi.nlm.nih.gov/21730979