Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183

Autor: Katherine A. Abrahams, Wei Hu, Gang Li, Yu Lu, Emily J. Richardson, Nicholas J. Loman, Haihong Huang, Gurdyal S. Besra

Publikováno v: The Cell Surface, Vol 6, Iss , Pp 100040- (2020)

The emergence and perseverance of drug resistant strains of Mycobacterium tuberculosis (Mtb) ensures that drug discovery efforts remain at the forefront of tuberculosis research. There are numerous different approaches that can be employed to lead to

Externí odkaz: https://doaj.org/article/763a2eec32d146b686041feaf3aa66fd

Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen

Autor: Maan M Neamah, Pilar Horcajo, Emily J Richardson, Andreas F. Haag, Ricardo de la Fuente, Gonzalo Yebra, Bryan A. Wee, María Ángeles Tormo-Más, J. Ross Fitzgerald, Sander Granneman, José R. Penadés

Publikováno v: CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
PLoS Pathogens
PLOS PATHOGENS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Yebra, G, Haag, A F, Neamah, M M, Wee, B A, Richardson, E J, Horcajo, P, Granneman, S, Tormo-Más, M Á, de la Fuente, R, Fitzgerald, J R & Penadés, J R 2021, ' Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen ', PLoS Pathogens, vol. 17, no. 5, e1009606 . https://doi.org/10.1371/journal.ppat.1009606
PLoS Pathogens, Vol 17, Iss 5, p e1009606 (2021)

The emergence of new pathogens is a major threat to public and veterinary health. Changes in bacterial habitat such as a switch in host or disease tropism are typically accompanied by genetic diversification. Staphylococcus aureus is a multi-host bac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ea771c8c0c9536f76b592a17d0e5af
https://doi.org/10.1371/journal.ppat.1009606

Meta4: a web-application for sharing and annotating metagenomic gene predictions using web-services

Autor: Emily J Richardson, Franck eEscalettes, Ian eFotheringham, Robert John Wallace, Mick eWatson

Publikováno v: Frontiers in Genetics, Vol 4 (2013)

Whole-genome-shotgun (WGS) metagenomics experiments produce DNA sequence data from entire ecosystems, and provide a huge amount of novel information. Gene discovery projects require up-to-date information about sequence homology and domain structure

Externí odkaz: https://doaj.org/article/9a0cc875756e4c018f69e632d7bcc932

A multi-targeting pre-clinical candidate against drug-resistant tuberculosis

Autor: Shruthi Thimmalapura Gangadharaiah, Rajesh Mondal, C N Naveenkumar, Vijaykamal Ahuja, Radha Shandil, Shridhar Narayanan, Prasad Shivarudraiah, Gurdyal S. Besra, Sarah M. Batt, Azger Dusthackeer, Vijay Potluri, Balasubramanian Mahizhaveni, Christy Rosaline Nirmal, Emily J. Richardson, Parvinder Kaur, Sumesh Eswaran, Ramya Vadageri Krishnamurthy, Nicholas J. Loman

Publikováno v: Tuberculosis. 129:102104

FNDR-20081 [4-{4-[5-(4-Isopropyl-phenyl)- [1,2,4]oxadiazol-3-ylmethyl]-piperazin-1-yl}-7-pyridin-3-yl-quinoline] is a novel, first in class anti-tubercular pre-clinical candidate against sensitive and drug-resistant Mycobacterium tuberculosis (Mtb).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6629eb69d38f75cdafd5246693a14ca7
https://doi.org/10.1016/j.tube.2021.102104

Characterization of a bacteriophage from avian Staphylococcus aureus associated with innate immune evasion

Autor: J. Ross Fitzgerald, David A. Hume, Emily Parr, Emily J Richardson

Publikováno v: Access Microbiology. 1

Staphylococcus aureus is an important human and livestock pathogen. An S. aureus phage (φAvβ) inserted into the chromosome at the beta toxin gene (beta-converting phage) is present in approx. 90 % of human strains and contributes to human-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98a7d0f7137fdc4afc5c97fde3fe1b20
https://doi.org/10.1099/acmi.ac2019.po0178