Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Emily J. Reinhard"'
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 2)
Autor:
Miller Raymond E, Wei Huang, Horng-Chih Huang, Jay S. Trivedi, Scott R. Both, Nigam P. Rath, David B. Reitz, Deborah A. Mischke, Len F. Lee, Samuel J. Tremont, Steve R. Rapp, Danny J. Garland, Claude Jones, Banerjee Shyamal C, Matthew W. Mahoney, Theresa Fletcher, Michael B. Tollefson, Karen Regina, Emily J. Reinhard, Grace M. Wagner, Mark E. Smith, Judy Beaudry, J.-H Li, Kevin C. Glenn, Bradley T. Keller, Robert E. Manning, Kevin J. Koeller, Joe R. Schuh, Kolodziej Steve A, William F. Vernier, Carpenter Andrew J, Ching-Cheng Wang
Publikováno v:
Journal of Medicinal Chemistry. 48:5853-5868
In the preceding paper several compounds were reported as potent apical sodium-codependent bile acid transporter (ASBT) inhibitors. Since the primary site for active bile acid reabsorption is via ASBT, which is localized on the luminal surface of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8126ad3914a164ee565779032f3a9bd
https://doi.org/10.1021/jm0402162
https://doi.org/10.1021/jm0402162
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 1)
Autor:
Len F. Lee, James C. B. Li, William F. Vernier, Samuel J. Tremont, Miller Raymond E, Claude Jones, Wei Huang, Kevin J. Koeller, Robert E. Manning, Andrew J. Carpenter, Mark E. Smith, Scott R. Both, Nigam P. Rath, Joe R. Schuh, Michael B. Tollefson, Jay S. Trivedi, Danny J. Garland, Emily J. Reinhard, Deborah A. Mischke, Karen Regina, David B. Reitz, Grace M. Wagner, Ching-Cheng Wang, Kolodziej Steve A, Kevin C. Glenn, Keller Bradley T, Steve R. Rapp, Banerjee Shyamal C, Theresa R. Fletcher, Horng-Chih Huang, Judy Beaudry, Matthew W. Mahoney
Publikováno v:
Journal of Medicinal Chemistry. 48:5837-5852
Elevated plasma levels of low-density lipoprotein (LDL) cholesterol are a major risk factor for atherosclerosis leading to coronary artery disease (CAD), which remains the main cause of mortality in Western society. We believe that by preventing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eb4d79f2a819622faa896314c94f38
https://doi.org/10.1021/jm040215+
https://doi.org/10.1021/jm040215+
Autor:
Jane L. Wang, Michael B. Tollefson, Margaret L. Grapperhaus, James A. Sikorski, Richard C. Durley, Monica B. Norton, Michele A. Promo, Michele A. Melton, Mark A. Massa, Emily J. Reinhard, Brian S. Hickory, William F. Vernier, Mark E. Smith, Yvette M. Fobian, Karen Regina, Bryan J. Witherbee, Daniel T. Connolly
Publikováno v:
Journal of Medicinal Chemistry. 46:2152-2168
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b10e457203bbb1110208e3911dfa6aac
https://doi.org/10.1021/jm020528+
https://doi.org/10.1021/jm020528+
Autor:
Gary D. Anderson, A. W. Veenhuizen, Carol M. Koboldt, Karen Seibert, Robert E. Manning, William E. Perkins, Yan Zhang, Horng-Chi Huang, J. N. Cogburn, D. J. Garland, Jinglin Li, Emily J. Reinhard, David B. Reitz, S. A. Gregory, Timothy S. Chamberlain, E. G. Burton, Peter C. Isakson
Publikováno v:
Journal of Medicinal Chemistry. 39:253-266
A novel series of 5,6-diarylspiro[2.4]hept-5-enes was shown to provide highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. A study of structure-activity relationships in this series suggests that 3,4-disubstituted phenyl analogs are gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9ef2e75bc7cbe29bd4ca9744f026f5
https://doi.org/10.1021/jm950664x
https://doi.org/10.1021/jm950664x
Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents
Autor:
Peter C. Isakson, James J. Li, David B. Reitz, G. D. Anderson, Monica B. Norton, Carol M. Koboldt, Jaime L. Masferrer, Gregory Susan A, Emily J. Reinhard, Karen Seibert, Yan Zhang, Ben S. Zweifel, William Perkins
Publikováno v:
Journal of Medicinal Chemistry. 39:1846-1856
A novel series of terphenyl methyl sulfones and sulfonamides have been shown to be highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. The sulfonamide analogs 17 and 21 were found to be much more potent COX-2 inhibitors and orally active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a6917aad0904e60acdaab0eb7bd0ed
https://doi.org/10.1021/jm950878e
https://doi.org/10.1021/jm950878e
Publikováno v:
Tetrahedron Letters. 35:7201-7204
A one-pot synthesis of sulfonamides from methyl sulfones has been developed. Treatment of methyl sulfones with base and trialkylboranes gave the corresponding rearranged sulfinic acid salts which were converted to sulfonamides during oxidative-aminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dcc821c49c3bdf87fde5f0f80ba8f5d
https://doi.org/10.1016/0040-4039(94)85360-6
https://doi.org/10.1016/0040-4039(94)85360-6
Autor:
David B. Reitz, Ellen G. McMahon, Maria A. Palomo, Mark A. Penick, Gillian M. Olins, Brian Kai-Ming Cheng, Dean E. McGraw, Valerie M. Corpus, Emily J. Reinhard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:99-104
Substituting nitrogen for carbon in the pyridinylphenylmethyl analogs of SC-50560 proved to be detrimental, however, the two phenylpyridinylmethyl analogs of SC-50560 retained their potencies. Of these two analogs, SC-52458 was found to have superior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f40889f2e3d0a1f9d2774bd16683f67
https://doi.org/10.1016/s0960-894x(01)81129-x
https://doi.org/10.1016/s0960-894x(01)81129-x
Autor:
Maria A. Palomo, Danny J. Garland, Konrad F. Koehler, David B. Reitz, Monica B. Norton, Emily J. Reinhard, Gillian M. Olins, Susan T. Chen, Robert E. Manning, J. T. Collins, Ellen G. McMahon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1055-1060
The surmountable (competitive) N 1 -(2-methylphenyl)-2H-imidazol-2-one angiotensin II receptor antagonist SC-54628 is converted to an insurmountable (noncompetitive) antagonist SC-54629 by the addition of a methyl group at the 6-position of the pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e31096603038f887f225236b63745d
https://doi.org/10.1016/s0960-894x(00)80286-3
https://doi.org/10.1016/s0960-894x(00)80286-3
Autor:
D. E. Mcgraw, V. M. Corpus, Gillian M. Olins, Brian Kai-Ming Cheng, Ellen G. McMahon, Mark A. Penick, Maria A. Palomo, David B. Reitz, Emily J. Reinhard
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c55762b9eb0f848054a10958b12f31e5
https://doi.org/10.1002/chin.199426161
https://doi.org/10.1002/chin.199426161
Autor:
Monica B. Norton, Maria A. Palomo, David B. Reitz, Ellen G. McMahon, V. M. Corpus, Mark A. Penick, Gillian M. Olins, D. E. Mcgraw, Emily J. Reinhard
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf1cf561d66553ca56c04a1a6498f3b
https://doi.org/10.1002/chin.199426162
https://doi.org/10.1002/chin.199426162