Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Emily J. Fray"'
Autor:
Ellie Mainou, Stella J. Berendam, Veronica Obregon-Perko, Emilie A. Uffman, Caroline T. Phan, George M. Shaw, Katharine J. Bar, Mithra R. Kumar, Emily J. Fray, Janet M. Siliciano, Robert F. Siliciano, Guido Silvestri, Sallie R. Permar, Genevieve G. Fouda, Janice McCarthy, Ann Chahroudi, Jessica M. Conway, Cliburn Chan
Publikováno v:
Epidemics, Vol 48, Iss , Pp 100780- (2024)
While the benefits of early antiretroviral therapy (ART) initiation in perinatally infected infants are well documented, early initiation is not always possible in postnatal pediatric HIV infections. The timing of ART initiation is likely to affect t
Externí odkaz:
https://doaj.org/article/60d2aef43b0643d1af9bb0c95351b590
Autor:
Natalie F. McMyn, Joseph Varriale, Emily J. Fray, Carolin Zitzmann, Hannah MacLeod, Jun Lai, Anushka Singhal, Milica Moskovljevic, Mauro A. Garcia, Brianna M. Lopez, Vivek Hariharan, Kyle Rhodehouse, Kenneth Lynn, Pablo Tebas, Karam Mounzer, Luis J. Montaner, Erika Benko, Colin Kovacs, Rebecca Hoh, Francesco R. Simonetti, Gregory M. Laird, Steven G. Deeks, Ruy M. Ribeiro, Alan S. Perelson, Robert F. Siliciano, Janet M. Siliciano
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first 7 years of ART (t1/2 = 44 months). However, whether decay continues with long-term ART is unclear. Recent in
Externí odkaz:
https://doaj.org/article/16cb14484f3b4a688aeb5fd64cf309ef
Autor:
Victoria E. K. Walker-Sperling, Noe B. Mercado, Abishek Chandrashekar, Erica N. Borducchi, Jinyan Liu, Joseph P. Nkolola, Mark Lewis, Jeffrey P. Murry, Yunling Yang, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Maria G. Pau, Frank Wegmann, Hanneke Schuitemaker, Emily J. Fray, Mithra R. Kumar, Janet D. Siliciano, Robert F. Siliciano, Dan H. Barouch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Antiretroviral therapy alone is insufficient in curing HIV-1 infection, due to latent viral reservoir persistency. Here, authors explore the post-virologic control of combining active and passive immunisation with vesatolimod, in a SHIV-infected rhes
Externí odkaz:
https://doaj.org/article/3d61c11904ca4bafb0acb1d4d9eb6212
Autor:
John D. Ventura, Joseph P. Nkolola, Abishek Chandrashekar, Erica N. Borducchi, Jinyan Liu, Noe B. Mercado, David L. Hope, Victoria M. Giffin, Katherine McMahan, Romas Geleziunas, Jeffrey P. Murry, Yunling Yang, Mark G. Lewis, Maria G. Pau, Frank Wegmann, Hanneke Schuitemaker, Emily J. Fray, Mithra R. Kumar, Janet D. Siliciano, Robert F. Siliciano, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Developing an intervention that results in virologic control following discontinuation of antiretroviral therapy (ART) is a major objective of HIV-1 cure research. In this study, we investigated the therapeutic efficacy of a vaccine consisti
Externí odkaz:
https://doaj.org/article/e42cb38a5f4c44cdb752a66e3a3f759b
Autor:
Maura Statzu, Wang Jin, Emily J. Fray, Andrew Kam Ho Wong, Mithra R. Kumar, Elizabeth Ferrer, Steffen S. Docken, Mykola Pinkevych, Julia B. McBrien, Christine M. Fennessey, Brandon F. Keele, Shan Liang, Justin L. Harper, Simona Mutascio, Lavinia Franchitti, Hong Wang, Davide Cicetti, Steven E. Bosinger, Diane G. Carnathan, Thomas H. Vanderford, David M. Margolis, J. Victor Garcia-Martinez, Ann Chahroudi, Mirko Paiardini, Janet Siliciano, Miles P. Davenport, Deanna A. Kulpa, Robert S. Siliciano, Guido Silvestri
Publikováno v:
Nature Microbiology. 8:299-308
Persistence of the human immunodeficiency virus type-1 (HIV-1) latent reservoir in infected individuals remains a problem despite fully suppressive antiretroviral therapy (ART). While reservoir formation begins during acute infection, the mechanisms
Autor:
Helen L. Wu, Kathleen Busman-Sahay, Whitney C. Weber, Courtney M. Waytashek, Carla D. Boyle, Katherine B. Bateman, Jason S. Reed, Joseph M. Hwang, Christine Shriver-Munsch, Tonya Swanson, Mina Northrup, Kimberly Armantrout, Heidi Price, Mitch Robertson-LeVay, Samantha Uttke, Mithra R. Kumar, Emily J. Fray, Sol Taylor-Brill, Stephen Bondoc, Rebecca Agnor, Stephanie L. Junell, Alfred W. Legasse, Cassandra Moats, Rachele M. Bochart, Joseph Sciurba, Benjamin N. Bimber, Michelle N. Sullivan, Brandy Dozier, Rhonda P. MacAllister, Theodore R. Hobbs, Lauren D. Martin, Angela Panoskaltsis-Mortari, Lois M.A. Colgin, Robert F. Siliciano, Janet D. Siliciano, Jacob D. Estes, Jeremy V. Smedley, Michael K. Axthelm, Gabrielle Meyers, Richard T. Maziarz, Benjamin J. Burwitz, Jeffrey J. Stanton, Jonah B. Sacha
Publikováno v:
Immunity.
Autor:
Emily J. Fray, Fengting Wu, Francesco R. Simonetti, Carolin Zitzmann, Narmada Sambaturu, Carmen Molina-Paris, Alexandra M. Bender, Po-Ting Liu, John D. Ventura, Roger W. Wiseman, David H. O’Connor, Romas Geleziunas, Thomas Leitner, Ruy M. Ribeiro, Alan S. Perelson, Dan H. Barouch, Janet D. Siliciano, Robert F. Siliciano
Publikováno v:
Cell Host & Microbe. 31:356-372.e5
Autor:
Srona Sengupta, Nathan L. Board, Fengting Wu, Milica Moskovljevic, Jacqueline Douglass, Josephine Zhang, Bruce R. Reinhold, Jonathan Duke-Cohan, Jeanna Yu, Madison C. Reed, Yasmine Tabdili, Aitana Azurmendi, Emily J. Fray, Hao Zhang, Emily Han-Chung Hsiue, Katharine Jenike, Ya-Chi Ho, Sandra B. Gabelli, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Janet D. Siliciano, Scheherazade Sadegh-Nasseri, Ellis L. Reinherz, Robert F. Siliciano
Publikováno v:
Proceedings of the National Academy of Sciences. 119
HIV-1 infection is incurable due to the persistence of the virus in a latent reservoir of resting memory CD4+ T cells. “Shock-and-kill” approaches that seek to induce HIV-1 gene expression, protein production, and subsequent targeting by the host
Autor:
Robert F. Siliciano, Cynthia K Bullen, Peggy Kim, Janet D. Siliciano, Subul A. Beg, Jun Lai, Emily J. Fray, Carrie Hetzel, Andrew E. Timmons, Chao Yang, Weiwei Dai, Steven A. Yukl, Fengting Wu, Joel L. Pomerantz, Mithra Kumar
Publikováno v:
Proceedings of the National Academy of Sciences. 117:15763-15771
HIV-1 latency is a major barrier to cure. Identification of small molecules that destabilize latency and allow immune clearance of infected cells could lead to treatment-free remission. In vitro models of HIV-1 latency involving cell lines or primary
Autor:
Victoria E. K. Walker-Sperling, Noe B. Mercado, Abishek Chandrashekar, Erica N. Borducchi, Jinyan Liu, Joseph P. Nkolola, Mark Lewis, Jeffrey P. Murry, Yunling Yang, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Maria G. Pau, Frank Wegmann, Hanneke Schuitemaker, Emily J. Fray, Mithra R. Kumar, Janet D. Siliciano, Robert F. Siliciano, Dan H. Barouch
Publikováno v:
Nature communications. 13(1)
The latent viral reservoir is the critical barrier for developing an HIV-1 cure. Previous studies have shown that therapeutic vaccination or broadly neutralizing antibody (bNAb) administration, together with a Toll-like receptor 7 (TLR7) agonist, enh