Výsledky vyhledávání - "Emily J. Fairmaid"

The role of gene segment interactions in driving the emergence of dominant gene constellations during influenza virus reassortment

Autor: Joanna C. A. Cobbin, Lorena E. Brown, Steven Rockman, Sanja Trifkovic, Emily J. Fairmaid, Brad Gilbertson

A segmented genome enables influenza virus to undergo reassortment when two viruses infect the same cell. Resulting reassorted progeny have a spectrum of gene constellations and potentially different phenotypes. Although reassortment is involved in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc48674b4c8ea08c7348f28e7a48f915
https://hdl.handle.net/2123/26577

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Akademický článek

Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model.

Autor: Germain J P Fernando, Xianfeng Chen, Tarl W Prow, Michael L Crichton, Emily J Fairmaid, Michael S Roberts, Ian H Frazer, Lorena E Brown, Mark A F Kendall

Publikováno v: PLoS ONE, Vol 5, Iss 4, p e10266 (2010)

BackgroundOver 14 million people die each year from infectious diseases despite extensive vaccine use [1]. The needle and syringe--first invented in 1853--is still the primary delivery device, injecting liquid vaccine into muscle. Vaccines could be f

Externí odkaz: https://doaj.org/article/513f0894b14147b3946ebd930b55e4f0

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Establishment of functional influenza virus-specific CD8+ T cell memory pools after intramuscular immunization

Autor: Zhongfang Wang, Javier Vega Ramos, David C. Jackson, Katherine Kedzierska, Brendon Y. Chua, Lorena E. Brown, Emily J. Fairmaid, Sergio M. Quiñones Parra

Publikováno v: Vaccine. 33:5148-5154

The emergence of the avian-origin influenza H7N9 virus and its pandemic potential has highlighted the ever-present need to develop vaccination approaches to induce cross-protective immunity. In this study, we examined the establishment of cross-react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a220d5969fe464dd94df0613d2c7555c
https://doi.org/10.1016/j.vaccine.2015.08.001

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Factors associated with transmission of influenza-like illness in a cohort of households containing multiple children

Autor: Lorena E. Brown, Jodie McVernon, Karin Leder, Emily J. Fairmaid, James M. McCaw, Chelsea R Brown, Martha Irvine Sinclair

Publikováno v: Influenza and Other Respiratory Viruses

Background Household studies of influenza-like illness (ILI) afford opportunities to study determinants of respiratory virus transmission. Objectives We examined predictors of ILI transmission within households containing at least two children. Metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb4e5bc784a456eccf686230c0c4d45
http://europepmc.org/articles/PMC4548994

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Site-Selectively Coated, Densely-Packed Microprojection Array Patches for Targeted Delivery of Vaccines to Skin

Autor: Sally R. Yukiko, Xianfeng Chen, Emily J. Fairmaid, Holly J. Corbett, Anthony P. Raphael, Lorena E. Brown, Tarl W. Prow, Mark A. F. Kendall, Germain J. P. Fernando

Publikováno v: Advanced Functional Materials. 21:464-473

Densely packed dry-coated microprojections are shown to deliver vaccines to targeted locations within the skin that are rich in immune cells, thus inducing protective immune responses against a lethal virus challenge. Selectively limiting the antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6957995e3800b9dd95b0ff4c56394bc8
https://doi.org/10.1002/adfm.201000966

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Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: extending the potential of broadly cross-protecting epitopes

Autor: Anton P. J. Middelberg, Nani Wibowo, Lorena E. Brown, Linda H.L. Lua, Emily J. Fairmaid, Fiona K. Hughes

Publikováno v: Vaccine. 32(29)

Influenza A viruses drift and shift, emerging as antigenically distinct strains that lead to epidemics and pandemics of varying severity. Even epitopes associated with broad cross-protection against different strains, such as the ectodomain of matrix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c25dbc1f95ce489fa518059eae4bef
https://pubmed.ncbi.nlm.nih.gov/24795225

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Nanopatch targeted delivery of both antigen and adjuvant to skin synergistically drives enhanced antibody responses

Autor: Sally R. Yukiko, Holly J. Corbett, Clare A. Primiero, Xianfeng Chen, Emily J. Fairmaid, Lorena E. Brown, Germain J. P. Fernando, Mark A. F. Kendall, Ian H. Frazer

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 159(2)

Many vaccines make use of an adjuvant to achieve stronger immune responses. Alternatively, potent immune responses have also been generated by replacing the standard needle and syringe (which places vaccine into muscle) with devices that deliver vacc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410cf17399142d8cca6e137d4697a095
https://pubmed.ncbi.nlm.nih.gov/22306334

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Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin

Autor: Germain J. P. Fernando, Anthony P. Raphael, Emily J. Fairmaid, Mark A. F. Kendall, Lorena E. Brown, Sally R. Yukiko, Clare A. Primiero, Xianfeng Chen, Ian H. Frazer

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 158(1)

A rapid time to peak serum antibody response following vaccination is particularly important for influenza: the time window between the availability of appropriate antigen and the start of the seasonal epidemic is very short. In this paper, influenza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2edf4b06f583d3302d2412a5b26238b
https://pubmed.ncbi.nlm.nih.gov/22063004

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Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization

Autor: Holly J. Corbett, Alexander B. Ansaldo, Emily J. Fairmaid, Sally R. Yukiko, Lorena E. Brown, Mark A. F. Kendall, Ian H. Frazer, Christopher Flaim, Clare A. Primiero, Germain J. P. Fernando, Michael L. Crichton, Xianfeng Chen

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 152(3)

Dry-coated microprojections can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient immune responses and the dry-coated vaccines are expected to be thermostable at elevated temperatures. In this paper, we show that w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5affbd9ce4c73515141178094bfd0a
https://pubmed.ncbi.nlm.nih.gov/21600940

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Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model

Autor: Xianfeng Chen, Lorena E. Brown, Michael S. Roberts, Tarl W. Prow, Michael L. Crichton, Emily J. Fairmaid, Germain J. P. Fernando, Ian H. Frazer, Mark A. F. Kendall

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 4, p e10266 (2010)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9670614116c0f2f57baed9825eece51
https://pubmed.ncbi.nlm.nih.gov/20422002

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